Gene/Proteome Database (LMPD)
LMPD ID
LMP000693
Gene ID
Species
Homo sapiens (Human)
Gene Name
acyloxyacyl hydrolase (neutrophil)
Gene Symbol
Synonyms
-
Alternate Names
acyloxyacyl hydrolase
Chromosome
7
Map Location
7p14-p12
EC Number
3.1.1.77
Summary
This locus encodes both the light and heavy subunits of acyloxyacyl hydrolase. The encoded enzyme catalyzes the hydrolysis of acyloxylacyl-linked fatty acyl chains from bacterial lipopolysaccharides, effectively detoxifying these molecules. The encoded protein may play a role in modulating host inflammatory response to gram-negative bacteria. Alternatively spliced transcript variants have been described.[provided by RefSeq, Apr 2010]
Orthologs
Proteins
| acyloxyacyl hydrolase isoform 1 preproprotein | |
|---|---|
| Refseq ID | NP_001628 |
| Protein GI | 4502115 |
| UniProt ID | P28039 |
| mRNA ID | NM_001637 |
| Length | 575 |
| RefSeq Status | REVIEWED |
| MQSPWKILTVAPLFLLLSLQSSASPANDDQSRPSLSNGHTCVGCVLVVSVIEQLAQVHNSTVQASMERLCSYLPEKLFLKTTCYLVIDKFGSDIIKLLSADMNADVVCHTLEFCKQNTGQPLCHLYPLPKETWKFTLQKARQIVKKSPILKYSRSGSDICSLPVLAKICQKIKLAMEQSVPFKDVDSDKYSVFPTLRGYHWRGRDCNDSDESVYPGRRPNNWDVHQDSNCNGIWGVDPKDGVPYEKKFCEGSQPRGIILLGDSAGAHFHISPEWITASQMSLNSFINLPTALTNELDWPQLSGATGFLDSTVGIKEKSIYLRLWKRNHCNHRDYQNISRNGASSRNLKKFIESLSRNKVLDYPAIVIYAMIGNDVCSGKSDPVPAMTTPEKLYSNVMQTLKHLNSHLPNGSHVILYGLPDGTFLWDNLHNRYHPLGQLNKDMTYAQLYSFLNCLQVSPCHGWMSSNKTLRTLTSERAEQLSNTLKKIAASEKFTNFNLFYMDFAFHEIIQEWQKRGGQPWQLIEPVDGFHPNEVALLLLADHFWKKVQLQWPQILGKENPFNPQIKQVFGDQGGH | |
| sig_peptide: 1..23 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2544 peptide sequence: MQSPWKILTVAPLFLLLSLQSSA mat_peptide: 35..156 product: acyloxyacyl hydrolase small subunit isoform 2 calculated_mol_wt: 13702 peptide sequence: LSNGHTCVGCVLVVSVIEQLAQVHNSTVQASMERLCSYLPEKLFLKTTCYLVIDKFGSDIIKLLSADMNADVVCHTLEFCKQNTGQPLCHLYPLPKETWKFTLQKARQIVKKSPILKYSRSG mat_peptide: 157..688 product: acyloxyacyl hydrolase large subunit isoform 2 calculated_mol_wt: 60568 peptide sequence: SDICSLPVLAKICQKIKLAMEQSVPFKDVDSDKYSVFPTLRGYHWRGRDCNDSDESVYPGRRPNNWDVHQDSNCNGIWGVDPKDGVPYEKKFCEGSQPRGIILLGDSAGAHFHISPEWITASQMSLNSFINLPTALTNELDWPQLSGATGFLDSTVGIKEKSIYLRLWKRNHCNHRDYQNISRNGASSRNLKKFIESLSRNKVLDYPAIVIYAMIGNDVCSGKSDPVPAMTTPEKLYSNVMQTLKHLNSHLPNGSHVILYGLPDGTFLWDNLHNRYHPLGQLNKDMTYAQLYSFLNCLQVSPCHGWMSSNKTLRTLTSERAEQLSNTLKKIAASEKFTNFNLFYMDFAFHEIIQEWQKRGGQPWQLIEPVDGFHPNERKSILLKGILMTSQTLDNQEWTQLTSWIKGNLTCDSRTREWLCCCWRIISGKRCSSSGPKSWERRIRSTPRLNRCLETKAGTEPLRSMHPWGAQGGRGLGKLIPQTLWGLPRHRPKGLFFSSIFAKCLSLNEEHIWTTVQCCVLPGSVTLPLFLK sig_peptide: 1..23 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2544 peptide sequence: MQSPWKILTVAPLFLLLSLQSSA mat_peptide: 35..124 product: acyloxyacyl hydrolase small subunit isoform 3 calculated_mol_wt: 10245 peptide sequence: LSNGHTCVEKLFLKTTCYLVIDKFGSDIIKLLSADMNADVVCHTLEFCKQNTGQPLCHLYPLPKETWKFTLQKARQIVKKSPILKYSRSG mat_peptide: 125..543 product: acyloxyacyl hydrolase large subunit isoform 3 calculated_mol_wt: 47739 peptide sequence: SDICSLPVLAKICQKIKLAMEQSVPFKDVDSDKYSVFPTLRGYHWRGRDCNDSDESVYPGRRPNNWDVHQDSNCNGIWGVDPKDGVPYEKKFCEGSQPRGIILLGDSAGAHFHISPEWITASQMSLNSFINLPTALTNELDWPQLSGATGFLDSTVGIKEKSIYLRLWKRNHCNHRDYQNISRNGASSRNLKKFIESLSRNKVLDYPAIVIYAMIGNDVCSGKSDPVPAMTTPEKLYSNVMQTLKHLNSHLPNGSHVILYGLPDGTFLWDNLHNRYHPLGQLNKDMTYAQLYSFLNCLQVSPCHGWMSSNKTLRTLTSERAEQLSNTLKKIAASEKFTNFNLFYMDFAFHEIIQEWQKRGGQPWQLIEPVDGFHPNEVALLLLADHFWKKVQLQWPQILGKENPFNPQIKQVFGDQGGH sig_peptide: 1..23 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2544 peptide sequence: MQSPWKILTVAPLFLLLSLQSSA mat_peptide: 35..156 product: acyloxyacyl hydrolase small subunit isoform 1 calculated_mol_wt: 13702 peptide sequence: LSNGHTCVGCVLVVSVIEQLAQVHNSTVQASMERLCSYLPEKLFLKTTCYLVIDKFGSDIIKLLSADMNADVVCHTLEFCKQNTGQPLCHLYPLPKETWKFTLQKARQIVKKSPILKYSRSG mat_peptide: 157..575 product: acyloxyacyl hydrolase large subunit isoform 1 calculated_mol_wt: 47739 peptide sequence: SDICSLPVLAKICQKIKLAMEQSVPFKDVDSDKYSVFPTLRGYHWRGRDCNDSDESVYPGRRPNNWDVHQDSNCNGIWGVDPKDGVPYEKKFCEGSQPRGIILLGDSAGAHFHISPEWITASQMSLNSFINLPTALTNELDWPQLSGATGFLDSTVGIKEKSIYLRLWKRNHCNHRDYQNISRNGASSRNLKKFIESLSRNKVLDYPAIVIYAMIGNDVCSGKSDPVPAMTTPEKLYSNVMQTLKHLNSHLPNGSHVILYGLPDGTFLWDNLHNRYHPLGQLNKDMTYAQLYSFLNCLQVSPCHGWMSSNKTLRTLTSERAEQLSNTLKKIAASEKFTNFNLFYMDFAFHEIIQEWQKRGGQPWQLIEPVDGFHPNEVALLLLADHFWKKVQLQWPQILGKENPFNPQIKQVFGDQGGH | |
| acyloxyacyl hydrolase isoform 2 preproprotein | |
|---|---|
| Refseq ID | NP_001170977 |
| Protein GI | 294610665 |
| UniProt ID | P28039 |
| mRNA ID | NM_001177506 |
| Length | 688 |
| RefSeq Status | REVIEWED |
| MQSPWKILTVAPLFLLLSLQSSASPANDDQSRPSLSNGHTCVGCVLVVSVIEQLAQVHNSTVQASMERLCSYLPEKLFLKTTCYLVIDKFGSDIIKLLSADMNADVVCHTLEFCKQNTGQPLCHLYPLPKETWKFTLQKARQIVKKSPILKYSRSGSDICSLPVLAKICQKIKLAMEQSVPFKDVDSDKYSVFPTLRGYHWRGRDCNDSDESVYPGRRPNNWDVHQDSNCNGIWGVDPKDGVPYEKKFCEGSQPRGIILLGDSAGAHFHISPEWITASQMSLNSFINLPTALTNELDWPQLSGATGFLDSTVGIKEKSIYLRLWKRNHCNHRDYQNISRNGASSRNLKKFIESLSRNKVLDYPAIVIYAMIGNDVCSGKSDPVPAMTTPEKLYSNVMQTLKHLNSHLPNGSHVILYGLPDGTFLWDNLHNRYHPLGQLNKDMTYAQLYSFLNCLQVSPCHGWMSSNKTLRTLTSERAEQLSNTLKKIAASEKFTNFNLFYMDFAFHEIIQEWQKRGGQPWQLIEPVDGFHPNERKSILLKGILMTSQTLDNQEWTQLTSWIKGNLTCDSRTREWLCCCWRIISGKRCSSSGPKSWERRIRSTPRLNRCLETKAGTEPLRSMHPWGAQGGRGLGKLIPQTLWGLPRHRPKGLFFSSIFAKCLSLNEEHIWTTVQCCVLPGSVTLPLFLK | |
| acyloxyacyl hydrolase isoform 3 preproprotein | |
|---|---|
| Refseq ID | NP_001170978 |
| Protein GI | 294610667 |
| UniProt ID | P28039 |
| mRNA ID | NM_001177507 |
| Length | 543 |
| RefSeq Status | REVIEWED |
| MQSPWKILTVAPLFLLLSLQSSASPANDDQSRPSLSNGHTCVEKLFLKTTCYLVIDKFGSDIIKLLSADMNADVVCHTLEFCKQNTGQPLCHLYPLPKETWKFTLQKARQIVKKSPILKYSRSGSDICSLPVLAKICQKIKLAMEQSVPFKDVDSDKYSVFPTLRGYHWRGRDCNDSDESVYPGRRPNNWDVHQDSNCNGIWGVDPKDGVPYEKKFCEGSQPRGIILLGDSAGAHFHISPEWITASQMSLNSFINLPTALTNELDWPQLSGATGFLDSTVGIKEKSIYLRLWKRNHCNHRDYQNISRNGASSRNLKKFIESLSRNKVLDYPAIVIYAMIGNDVCSGKSDPVPAMTTPEKLYSNVMQTLKHLNSHLPNGSHVILYGLPDGTFLWDNLHNRYHPLGQLNKDMTYAQLYSFLNCLQVSPCHGWMSSNKTLRTLTSERAEQLSNTLKKIAASEKFTNFNLFYMDFAFHEIIQEWQKRGGQPWQLIEPVDGFHPNEVALLLLADHFWKKVQLQWPQILGKENPFNPQIKQVFGDQGGH | |
Gene Information
Entrez Gene ID
Gene Name
acyloxyacyl hydrolase (neutrophil)
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005576 | IEA:UniProtKB-KW | C | extracellular region |
| GO:0050528 | IEA:UniProtKB-EC | F | acyloxyacyl hydrolase activity |
| GO:0003824 | TAS:ProtInc | F | catalytic activity |
| GO:0004465 | TAS:ProtInc | F | lipoprotein lipase activity |
| GO:0006954 | TAS:ProtInc | P | inflammatory response |
| GO:0006629 | TAS:ProtInc | P | lipid metabolic process |
| GO:0008653 | IEA:Ensembl | P | lipopolysaccharide metabolic process |
| GO:0050728 | IEA:Ensembl | P | negative regulation of inflammatory response |
Domain Information
UniProt Annotations
Entry Information
Gene Name
acyloxyacyl hydrolase (neutrophil)
Protein Entry
AOAH_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P28039-1; Sequence=Displayed; Name=2; IsoId=P28039-2; Sequence=VSP_042571; Note=No experimental confirmation available.; |
| Catalytic Activity | 3-(acyloxy)acyl group of bacterial toxin = 3- hydroxyacyl group of bacterial toxin + a fatty acid. |
| Function | Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides. |
| Ptm | Both subunits contain a number of cysteine residues that may form disulfide bridges. |
| Similarity | Contains 1 saposin B-type domain. |
| Subcellular Location | Secreted. |
| Subunit | Heterodimer. |
Identical and Related Proteins
Unique RefSeq proteins for LMP000693 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 4502115 | RefSeq | NP_001628 | 575 | acyloxyacyl hydrolase isoform 1 preproprotein |
| 294610665 | RefSeq | NP_001170977 | 688 | acyloxyacyl hydrolase isoform 2 preproprotein |
| 294610667 | RefSeq | NP_001170978 | 543 | acyloxyacyl hydrolase isoform 3 preproprotein |
Identical Sequences to LMP000693 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:294610667 | DBBJ | BAH12476.1 | 543 | unnamed protein product [Homo sapiens] |
| GI:4502115 | GenBank | AAA35506.1 | 575 | acyloxyacyl hydrolase [Homo sapiens] |
| GI:4502115 | GenBank | AAH25698.1 | 575 | Acyloxyacyl hydrolase (neutrophil) [Homo sapiens] |
| GI:4502115 | GenBank | ABM81866.1 | 575 | acyloxyacyl hydrolase (neutrophil) [synthetic construct] |
| GI:4502115 | GenBank | ABM85026.1 | 575 | acyloxyacyl hydrolase (neutrophil), partial [synthetic construct] |
| GI:4502115 | GenBank | AHD72428.1 | 575 | Sequence 9496 from patent US 8586006 |
| GI:4502115 | GenBank | AIC54011.1 | 575 | AOAH, partial [synthetic construct] |
Related Sequences to LMP000693 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:4502115 | DBBJ | BAD97196.1 | 575 | acyloxyacyl hydrolase precursor variant, partial [Homo sapiens] |
| GI:294610667 | GenBank | AAA35506.1 | 575 | acyloxyacyl hydrolase [Homo sapiens] |
| GI:4502115 | GenBank | EAL23977.1 | 575 | acyloxyacyl hydrolase (neutrophil) [Homo sapiens] |
| GI:4502115 | GenBank | EAW94073.1 | 575 | acyloxyacyl hydrolase (neutrophil) [Homo sapiens] |
| GI:294610667 | GenBank | AIC54011.1 | 575 | AOAH, partial [synthetic construct] |
| GI:294610665 | RefSeq | XP_002803366.1 | 669 | PREDICTED: acyloxyacyl hydrolase isoform 3 [Macaca mulatta] |
| GI:4502115 | RefSeq | XP_519044.3 | 575 | PREDICTED: acyloxyacyl hydrolase isoform X2 [Pan troglodytes] |
| GI:294610665 | RefSeq | XP_003318306.1 | 688 | PREDICTED: acyloxyacyl hydrolase isoform X5 [Pan troglodytes] |
| GI:294610667 | RefSeq | XP_003318307.1 | 543 | PREDICTED: acyloxyacyl hydrolase isoform X4 [Pan troglodytes] |
| GI:4502115 | RefSeq | XP_003815017.1 | 575 | PREDICTED: acyloxyacyl hydrolase isoform X1 [Pan paniscus] |
| GI:294610665 | RefSeq | XP_003815018.1 | 688 | PREDICTED: acyloxyacyl hydrolase isoform X3 [Pan paniscus] |
| GI:294610667 | RefSeq | XP_003815019.1 | 543 | PREDICTED: acyloxyacyl hydrolase isoform X2 [Pan paniscus] |
| GI:4502115 | RefSeq | XP_004045362.1 | 575 | PREDICTED: acyloxyacyl hydrolase isoform 1 [Gorilla gorilla gorilla] |
| GI:294610665 | RefSeq | XP_004045363.1 | 688 | PREDICTED: acyloxyacyl hydrolase isoform 2 [Gorilla gorilla gorilla] |
| GI:294610667 | RefSeq | XP_004045364.1 | 543 | PREDICTED: acyloxyacyl hydrolase isoform 3 [Gorilla gorilla gorilla] |
| GI:294610665 | RefSeq | XP_005549846.1 | 669 | PREDICTED: acyloxyacyl hydrolase isoform X1 [Macaca fascicularis] |
| GI:294610665 | RefSeq | XP_007979796.1 | 688 | PREDICTED: acyloxyacyl hydrolase isoform X2 [Chlorocebus sabaeus] |
| GI:294610667 | SwissProt | P28039.1 | 575 | RecName: Full=Acyloxyacyl hydrolase; Contains: RecName: Full=Acyloxyacyl hydrolase small subunit; Contains: RecName: Full=Acyloxyacyl hydrolase large subunit; Flags: Precursor [Homo sapiens] |