Gene/Proteome Database (LMPD)
LMPD ID
LMP000695
Gene ID
Species
Homo sapiens (Human)
Gene Name
very low density lipoprotein receptor
Gene Symbol
Synonyms
CARMQ1; CHRMQ1; VLDLRCH
Alternate Names
very low-density lipoprotein receptor; VLDL-R; VLDL receptor
Chromosome
9
Map Location
9p24
Summary
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. This gene encodes a lipoprotein receptor that is a member of the LDLR family and plays important roles in VLDL-triglyceride metabolism and the reelin signaling pathway. Mutations in this gene cause VLDLR-associated cerebellar hypoplasia. Alternative splicing generates multiple transcript variants encoding distinct isoforms for this gene. [provided by RefSeq, Aug 2009]
Orthologs
Proteins
| very low-density lipoprotein receptor isoform a precursor | |
|---|---|
| Refseq ID | NP_003374 |
| Protein GI | 65301167 |
| UniProt ID | P98155 |
| mRNA ID | NM_003383 |
| Length | 873 |
| RefSeq Status | REVIEWED |
| MGTSALWALWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATTVTYSETKDTNTTEISATSGLVPGGINVTTAVSEVSVPPKGTSAAWAILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKTTEEDLSIDIGRHSASVGHTYPAISVVSTDDDLA | |
| sig_peptide: 1..27 calculated_mol_wt: 2876 peptide sequence: MGTSALWALWLLLALCWAPRESGATGT mat_peptide: 28..845 product: very low-density lipoprotein receptor isoform b calculated_mol_wt: 90525 peptide sequence: GRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQRINVTTAVSEVSVPPKGTSAAWAILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKTTEEDLSIDIGRHSASVGHTYPAISVVSTDDDLA sig_peptide: 1..27 calculated_mol_wt: 2876 peptide sequence: MGTSALWALWLLLALCWAPRESGATGT mat_peptide: 28..873 product: very low-density lipoprotein receptor isoform a calculated_mol_wt: 93241 peptide sequence: GRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATTVTYSETKDTNTTEISATSGLVPGGINVTTAVSEVSVPPKGTSAAWAILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKTTEEDLSIDIGRHSASVGHTYPAISVVSTDDDLA | |
| very low-density lipoprotein receptor isoform b precursor | |
|---|---|
| Refseq ID | NP_001018066 |
| Protein GI | 65301164 |
| UniProt ID | P98155 |
| mRNA ID | NM_001018056 |
| Length | 845 |
| RefSeq Status | REVIEWED |
| MGTSALWALWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQRINVTTAVSEVSVPPKGTSAAWAILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKTTEEDLSIDIGRHSASVGHTYPAISVVSTDDDLA | |
Gene Information
Entrez Gene ID
Gene Name
very low density lipoprotein receptor
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005905 | IEA:UniProtKB-KW | C | coated pit |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0016020 | IDA:MGI | C | membrane |
| GO:0005886 | TAS:ProtInc | C | plasma membrane |
| GO:0043235 | IDA:MGI | C | receptor complex |
| GO:0034361 | IEA:UniProtKB-KW | C | very-low-density lipoprotein particle |
| GO:0034185 | IDA:BHF-UCL | F | apolipoprotein binding |
| GO:0005509 | IEA:InterPro | F | calcium ion binding |
| GO:0048306 | IPI:BHF-UCL | F | calcium-dependent protein binding |
| GO:0001948 | IPI:BHF-UCL | F | glycoprotein binding |
| GO:0034437 | IDA:BHF-UCL | F | glycoprotein transporter activity |
| GO:0005041 | TAS:ProtInc | F | low-density lipoprotein receptor activity |
| GO:0038025 | ISS:BHF-UCL | F | reelin receptor activity |
| GO:0034189 | IDA:BHF-UCL | F | very-low-density lipoprotein particle binding |
| GO:0030229 | IDA:BHF-UCL | F | very-low-density lipoprotein particle receptor activity |
| GO:0008203 | IEA:UniProtKB-KW | P | cholesterol metabolic process |
| GO:0034436 | IDA:BHF-UCL | P | glycoprotein transport |
| GO:0006869 | IEA:UniProtKB-KW | P | lipid transport |
| GO:0007613 | TAS:ProtInc | P | memory |
| GO:0000122 | ISS:BHF-UCL | P | negative regulation of transcription from RNA polymerase II promoter |
| GO:0007399 | TAS:ProtInc | P | nervous system development |
| GO:1900006 | ISS:BHF-UCL | P | positive regulation of dendrite development |
| GO:0045860 | IEA:Ensembl | P | positive regulation of protein kinase activity |
| GO:0006898 | IDA:BHF-UCL | P | receptor-mediated endocytosis |
| GO:0038026 | ISS:BHF-UCL | P | reelin-mediated signaling pathway |
| GO:0007165 | TAS:ProtInc | P | signal transduction |
| GO:0021517 | IEA:Ensembl | P | ventral spinal cord development |
| GO:0034447 | IDA:BHF-UCL | P | very-low-density lipoprotein particle clearance |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR001881 | EGF-like calcium-binding domain |
| IPR018097 | EGF-like calcium-binding, conserved site |
| IPR013032 | EGF-like, conserved site |
| IPR000152 | EGF-type aspartate/asparagine hydroxylation site |
| IPR000742 | Epidermal growth factor-like domain |
| IPR000033 | LDLR class B repeat |
| IPR002172 | Low-density lipoprotein (LDL) receptor class A repeat |
| IPR023415 | Low-density lipoprotein (LDL) receptor class A, conserved site |
| IPR011042 | Six-bladed beta-propeller, TolB-like |
UniProt Annotations
Entry Information
Gene Name
very low density lipoprotein receptor
Protein Entry
VLDLR_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=P98155-1; Sequence=Displayed; Name=Short; IsoId=P98155-2; Sequence=VSP_004304; |
| Disease | Cerebellar ataxia, mental retardation, and dysequilibrium syndrome 1 (CAMRQ1) [MIM |
| Function | Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation (By similarity). |
| Interaction | P30533:LRPAP1; NbExp=4; IntAct=EBI-9004309, EBI-715927; Q99068:Lrpap1 (xeno); NbExp=2; IntAct=EBI-9004309, EBI-919734; Q60841:Reln (xeno); NbExp=4; IntAct=EBI-9004309, EBI-9248666; |
| Ptm | Ubiquitinated at Lys-839 by MYLIP leading to degradation. |
| Similarity | Contains 3 EGF-like domains. {ECO |
| Similarity | Contains 6 LDL-receptor class B repeats. |
| Similarity | Contains 8 LDL-receptor class A domains. |
| Subcellular Location | Membrane; Single-pass type I membrane protein. Membrane, clathrin-coated pit; Single-pass type I membrane protein. |
| Subunit | Binds to the extracellular matrix protein Reelin. Interacts with VLDLR. Interacts with SNX17 (By similarity). Interacts with DAB1. Receptor for the minor-group human rhinoviruses (HRVs); binds protein VP1 through the second and third LDL-receptor class A domains. Interacts with PCSK9. {ECO |
| Tissue Specificity | Abundant in heart and skeletal muscle; also ovary and kidney; not in liver. |
| Web Resource | Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/vldlr/"; |
Identical and Related Proteins
Unique RefSeq proteins for LMP000695 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 65301167 | RefSeq | NP_003374 | 873 | very low-density lipoprotein receptor isoform a precursor |
| 65301164 | RefSeq | NP_001018066 | 845 | very low-density lipoprotein receptor isoform b precursor |
Identical Sequences to LMP000695 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:65301164 | DBBJ | BAJ20718.1 | 845 | very low density lipoprotein receptor, partial [synthetic construct] |
| GI:65301167 | GenBank | ABP04747.1 | 873 | Sequence 9 from patent US 7175999 |
| GI:65301164 | GenBank | AAI42654.1 | 845 | Very low density lipoprotein receptor [Homo sapiens] |
| GI:65301167 | GenBank | AAI36563.1 | 873 | Very low density lipoprotein receptor [Homo sapiens] |
| GI:65301164 | GenBank | AAI44246.1 | 845 | Very low density lipoprotein receptor [Homo sapiens] |
| GI:65301167 | GenBank | ADA53369.1 | 873 | Sequence 1199 from patent US 7625699 |
| GI:65301167 | GenBank | ADA53370.1 | 873 | Sequence 1200 from patent US 7625699 |
| GI:65301164 | GenBank | ADA53371.1 | 845 | Sequence 1201 from patent US 7625699 |
| GI:65301164 | GenBank | ADA53372.1 | 845 | Sequence 1202 from patent US 7625699 |
| GI:65301167 | GenBank | AFL62250.1 | 873 | Sequence 119 from patent US 8187833 |
| GI:65301167 | GenBank | AGD02500.1 | 873 | Sequence 119 from patent US 8338568 |
| GI:65301164 | GenBank | AIC55300.1 | 845 | VLDLR, partial [synthetic construct] |
Related Sequences to LMP000695 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:65301167 | GenBank | AAA53684.1 | 873 | very low density lipoprotein receptor [Homo sapiens] |
| GI:65301167 | GenBank | AAA61344.1 | 873 | very low density lipoprotein receptor [Homo sapiens] |
| GI:65301167 | GenBank | AAY69966.1 | 873 | Sequence 2 from patent US 6887463 |
| GI:65301167 | GenBank | ABY14307.1 | 873 | Sequence 2 from patent US 7306794 |
| GI:65301167 | GenBank | ACM84030.1 | 904 | Sequence 9528 from patent US 6812339 |
| GI:65301164 | GenBank | JAA04084.1 | 845 | very low density lipoprotein receptor [Pan troglodytes] |
| GI:65301164 | GenBank | JAA36755.1 | 845 | very low density lipoprotein receptor [Pan troglodytes] |
| GI:65301167 | pat | US | 873 | Sequence 2 from patent US 5652224 |
| GI:65301164 | RefSeq | XP_003823401.1 | 845 | PREDICTED: very low-density lipoprotein receptor isoform X2 [Pan paniscus] |
| GI:65301164 | RefSeq | XP_004047799.1 | 845 | PREDICTED: very low-density lipoprotein receptor isoform 1 [Gorilla gorilla gorilla] |
| GI:65301164 | RefSeq | XP_006716928.1 | 850 | PREDICTED: very low-density lipoprotein receptor isoform X2 [Homo sapiens] |
| GI:65301164 | RefSeq | XP_010387058.1 | 917 | PREDICTED: very low-density lipoprotein receptor isoform X2 [Rhinopithecus roxellana] |