Gene/Proteome Database (LMPD)
Proteins
| very low-density lipoprotein receptor isoform a precursor | |
|---|---|
| Refseq ID | NP_038731 |
| Protein GI | 238637303 |
| UniProt ID | P98156 |
| mRNA ID | NM_013703 |
| Length | 873 |
| RefSeq Status | VALIDATED |
| MGTSARWALWLLLALCWAPRDSGATASGKKAKCDSSQFQCTNGRCITLLWKCDGDEDCADGSDEKNCVKKTCAESDFVCKNGQCVPNRWQCDGDPDCEDGSDESPEQCHMRTCRINEISCGARSTQCIPVSWRCDGENDCDNGEDEENCGNITCSADEFTCSSGRCVSRNFVCNGQDDCDDGSDELDCAPPTCGAHEFQCSTSSCIPLSWVCDDDADCSDQSDESLEQCGRQPVIHTKCPTSEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDMSKVCDQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHFKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGAKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTEDIQWPNGITLDLVKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEDDMENGGCEYLCLPAPQINDHSPKYTCSCPNGYNLEENGRECQSTSTPVTYSETKDINTTDILRTSGLVPGGINVTTAVSEVSVPPKGTSAAWAILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKTTEEDLSIDIGRHSASVGHTYPAISVVSTDDDLA | |
| sig_peptide: 1..27 calculated_mol_wt: 2905 peptide sequence: MGTSARWALWLLLALCWAPRDSGATAS mat_peptide: 28..845 product: very low-density lipoprotein receptor isoform b calculated_mol_wt: 90649 peptide sequence: GKKAKCDSSQFQCTNGRCITLLWKCDGDEDCADGSDEKNCVKKTCAESDFVCKNGQCVPNRWQCDGDPDCEDGSDESPEQCHMRTCRINEISCGARSTQCIPVSWRCDGENDCDNGEDEENCGNITCSADEFTCSSGRCVSRNFVCNGQDDCDDGSDELDCAPPTCGAHEFQCSTSSCIPLSWVCDDDADCSDQSDESLEQCGRQPVIHTKCPTSEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDMSKVCDQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHFKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGAKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTEDIQWPNGITLDLVKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEDDMENGGCEYLCLPAPQINDHSPKYTCSCPNGYNLEENGRECQRINVTTAVSEVSVPPKGTSAAWAILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKTTEEDLSIDIGRHSASVGHTYPAISVVSTDDDLA sig_peptide: 1..27 calculated_mol_wt: 2905 peptide sequence: MGTSARWALWLLLALCWAPRDSGATAS mat_peptide: 28..873 product: very low-density lipoprotein receptor isoform a calculated_mol_wt: 93486 peptide sequence: GKKAKCDSSQFQCTNGRCITLLWKCDGDEDCADGSDEKNCVKKTCAESDFVCKNGQCVPNRWQCDGDPDCEDGSDESPEQCHMRTCRINEISCGARSTQCIPVSWRCDGENDCDNGEDEENCGNITCSADEFTCSSGRCVSRNFVCNGQDDCDDGSDELDCAPPTCGAHEFQCSTSSCIPLSWVCDDDADCSDQSDESLEQCGRQPVIHTKCPTSEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDMSKVCDQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHFKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGAKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTEDIQWPNGITLDLVKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEDDMENGGCEYLCLPAPQINDHSPKYTCSCPNGYNLEENGRECQSTSTPVTYSETKDINTTDILRTSGLVPGGINVTTAVSEVSVPPKGTSAAWAILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKTTEEDLSIDIGRHSASVGHTYPAISVVSTDDDLA | |
| very low-density lipoprotein receptor isoform b precursor | |
|---|---|
| Refseq ID | NP_001154892 |
| Protein GI | 238637305 |
| UniProt ID | P98156 |
| mRNA ID | NM_001161420 |
| Length | 845 |
| RefSeq Status | VALIDATED |
| MGTSARWALWLLLALCWAPRDSGATASGKKAKCDSSQFQCTNGRCITLLWKCDGDEDCADGSDEKNCVKKTCAESDFVCKNGQCVPNRWQCDGDPDCEDGSDESPEQCHMRTCRINEISCGARSTQCIPVSWRCDGENDCDNGEDEENCGNITCSADEFTCSSGRCVSRNFVCNGQDDCDDGSDELDCAPPTCGAHEFQCSTSSCIPLSWVCDDDADCSDQSDESLEQCGRQPVIHTKCPTSEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDMSKVCDQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHFKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGAKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTEDIQWPNGITLDLVKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEDDMENGGCEYLCLPAPQINDHSPKYTCSCPNGYNLEENGRECQRINVTTAVSEVSVPPKGTSAAWAILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKTTEEDLSIDIGRHSASVGHTYPAISVVSTDDDLA | |
Gene Information
Entrez Gene ID
Gene Name
very low density lipoprotein receptor
Gene Symbol
Species
Mus musculus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005905 | IEA:UniProtKB-KW | C | coated pit |
| GO:0005615 | IDA:BHF-UCL | C | extracellular space |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0016020 | ISO:MGI | C | membrane |
| GO:0043235 | ISO:MGI | C | receptor complex |
| GO:0034361 | IEA:UniProtKB-KW | C | very-low-density lipoprotein particle |
| GO:0005509 | IEA:InterPro | F | calcium ion binding |
| GO:0034437 | IEA:Ensembl | F | glycoprotein transporter activity |
| GO:0038025 | IGI:BHF-UCL | F | reelin receptor activity |
| GO:0034189 | IEA:Ensembl | F | very-low-density lipoprotein particle binding |
| GO:0030229 | ISS:BHF-UCL | F | very-low-density lipoprotein particle receptor activity |
| GO:0008203 | IEA:UniProtKB-KW | P | cholesterol metabolic process |
| GO:0006869 | IEA:UniProtKB-KW | P | lipid transport |
| GO:0000122 | IMP:BHF-UCL | P | negative regulation of transcription from RNA polymerase II promoter |
| GO:1900006 | IGI:BHF-UCL | P | positive regulation of dendrite development |
| GO:0045860 | IGI:MGI | P | positive regulation of protein kinase activity |
| GO:0038026 | IGI:BHF-UCL | P | reelin-mediated signaling pathway |
| GO:0021517 | IEP:UniProtKB | P | ventral spinal cord development |
| GO:0034447 | ISS:BHF-UCL | P | very-low-density lipoprotein particle clearance |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR001881 | EGF-like calcium-binding domain |
| IPR018097 | EGF-like calcium-binding, conserved site |
| IPR013032 | EGF-like, conserved site |
| IPR000152 | EGF-type aspartate/asparagine hydroxylation site |
| IPR000742 | Epidermal growth factor-like domain |
| IPR009030 | Insulin-like growth factor binding protein, N-terminal |
| IPR000033 | LDLR class B repeat |
| IPR002172 | Low-density lipoprotein (LDL) receptor class A repeat |
| IPR023415 | Low-density lipoprotein (LDL) receptor class A, conserved site |
| IPR011042 | Six-bladed beta-propeller, TolB-like |
UniProt Annotations
Entry Information
Gene Name
very low density lipoprotein receptor
Protein Entry
VLDLR_MOUSE
UniProt ID
Species
Mouse
Comments
| Comment Type | Description |
|---|---|
| Function | Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation. |
| Miscellaneous | LRP8 and VLVLR together are required for correct embryonic development in the brain. Targeted disruption of both genes results in a phenotype virtually indistinguishable from that seen in "reeler" and "scrambler" mice. Subtle effects of VLDLR deletion are found mainly in the cerebellum, whereas lack of LRP8 predominantly affects the positioning of the neurons in the neocortex. |
| Ptm | Ubiquitinated at Lys-839 by MYLIP leading to degradation. {ECO:0000250}. |
| Similarity | Contains 3 EGF-like domains. {ECO:0000255|PROSITE- ProRule:PRU00076}. |
| Similarity | Contains 6 LDL-receptor class B repeats. {ECO:0000255|PROSITE-ProRule:PRU00461}. |
| Similarity | Contains 8 LDL-receptor class A domains. {ECO:0000255|PROSITE-ProRule:PRU00124}. |
| Subcellular Location | Membrane; Single-pass type I membrane protein. Membrane, clathrin-coated pit; Single-pass type I membrane protein. |
| Subunit | Binds to the extracellular matrix protein Reelin. Interacts with DAB1. Interacts with VLDLR. Interacts with SNX17. Interacts with PCSK9 (By similarity). {ECO:0000250}. |
| Tissue Specificity | Abundant in heart and muscle; less in kidney, brain, ovary, testis, lung and adipose tissue. |
Identical and Related Proteins
Unique RefSeq proteins for LMP000696 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 238637303 | RefSeq | NP_038731 | 873 | very low-density lipoprotein receptor isoform a precursor |
| 238637305 | RefSeq | NP_001154892 | 845 | very low-density lipoprotein receptor isoform b precursor |
Identical Sequences to LMP000696 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:238637305 | GenBank | AAH13622.1 | 845 | Vldlr protein [Mus musculus] |
| GI:238637303 | GenBank | EDL41645.1 | 873 | very low density lipoprotein receptor, isoform CRA_a [Mus musculus] |
| GI:238637303 | RefSeq | XP_006526980.1 | 873 | PREDICTED: very low-density lipoprotein receptor isoform X1 [Mus musculus] |
| GI:238637303 | RefSeq | XP_006526981.1 | 873 | PREDICTED: very low-density lipoprotein receptor isoform X2 [Mus musculus] |
| GI:238637303 | SwissProt | P98156.1 | 873 | RecName: Full=Very low-density lipoprotein receptor; Short=VLDL receptor; Short=VLDL-R; Flags: Precursor [Mus musculus] |
Related Sequences to LMP000696 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:238637303 | GenBank | AAC37668.1 | 873 | very low density lipoprotein receptor [Mus musculus domesticus] |
| GI:238637303 | GenBank | AAA59384.1 | 873 | very low density lipoprotein receptor [Mus musculus] |
| GI:238637305 | GenBank | EDL41645.1 | 873 | very low density lipoprotein receptor, isoform CRA_a [Mus musculus] |
| GI:238637305 | GenBank | EDL41646.1 | 855 | very low density lipoprotein receptor, isoform CRA_b, partial [Mus musculus] |
| GI:238637303 | GenBank | AEJ67037.1 | 873 | Sequence 93 from patent US 7968301 |
| GI:238637303 | GenBank | AFL31432.1 | 873 | Sequence 93 from patent US 8173125 |
| GI:238637305 | RefSeq | NP_038731.2 | 873 | very low-density lipoprotein receptor isoform a precursor [Mus musculus] |
| GI:238637303 | RefSeq | XP_006231259.1 | 873 | PREDICTED: very low-density lipoprotein receptor isoform X1 [Rattus norvegicus] |
| GI:238637303 | RefSeq | XP_006231260.1 | 873 | PREDICTED: very low-density lipoprotein receptor isoform X1 [Rattus norvegicus] |
| GI:238637305 | RefSeq | XP_006231261.1 | 845 | PREDICTED: very low-density lipoprotein receptor isoform X2 [Rattus norvegicus] |
| GI:238637305 | RefSeq | XP_006526980.1 | 873 | PREDICTED: very low-density lipoprotein receptor isoform X1 [Mus musculus] |
| GI:238637305 | RefSeq | XP_006526981.1 | 873 | PREDICTED: very low-density lipoprotein receptor isoform X2 [Mus musculus] |