Gene/Proteome Database (LMPD)

LMPD ID
LMP000709
Gene ID
217480
Species
Mus musculus (Mouse)
Gene Name
diacylglycerol kinase, beta
Gene Symbol
Dgkb
Synonyms
6430574F24; 90kda; C630029D13Rik; DAGK2; DGK; DGK-beta; mKIAA0718
Alternate Names
diacylglycerol kinase beta; DAG kinase beta; diglyceride kinase beta
Chromosome
12
Map Location
12 A3|12
EC Number
2.7.1.107

Proteins

diacylglycerol kinase beta
Refseq ID NP_848796
Protein GI 83816899
UniProt ID Q6NS52
mRNA ID NM_178681
Length 795
RefSeq Status PROVISIONAL
MTNQEKWAHLSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLAKYNPEGTIDFEGFKLFMKTFLEAELPDDFTAHLFMSFSNKFPHSSPNVKSKPALLSGGLRMNKGAITPPRSSPANTCSPEVIHLKDIVCYLSLLERGRPEDKLEFMFRLYDTDGNGFLDSSELENIIGQMMHVAEYLEWDVTELNPILHEMMEEIDYDRDGTVSLEEWIQGGMTTIPLLVLLGLENNVKDDGQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSKKNTDVMHHYWVEGNCPTKCDKCHKTVKCYQGLTGLHCVWCQTTLHNKCASHLKPECDCGPLKDHILPPTTICPVVLTMPSAGASVPEERQSTAKKEKSSSQQPNKATDKNKMQRANSVTMDGQGLQITPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGLHFFRDVPDFRVLACGGDGTVGWILDCIEKANVVKHPPVAILPLGTGNDLARCLRWGGGYEGENLMKILKDIESSTEIMLDRWKFEVTPNDKDEKGDPVPYSIINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQIDLINISLEGIAILNIPSMHGGSNLWGESKKKRSHRRIEKKGSDKRPTLTDAKELKFASQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSSVVIRTSKSLPMQIDGEPWMQTPCTIKITHKNQAPMLMGPPPKTGLFCSLIKRTRNRSKE

Gene Information

Entrez Gene ID
217480
Gene Name
diacylglycerol kinase, beta
Gene Symbol
Dgkb
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0005886 IDA:MGI C plasma membrane
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0003951 IEA:InterPro F NAD+ kinase activity
GO:0005509 IEA:InterPro F calcium ion binding
GO:0004143 IDA:MGI F diacylglycerol kinase activity
GO:0035556 IEA:InterPro P intracellular signal transduction
GO:0007205 IEA:InterPro P protein kinase C-activating G-protein coupled receptor signaling pathway

KEGG Pathway Links

KEGG Pathway ID Description
mmu00561 Glycerolipid metabolism
mmu00564 Glycerophospholipid metabolism
mmu01100 Metabolic pathways
mmu04070 Phosphatidylinositol signaling system

Domain Information

InterPro Annotations

Accession Description
IPR016064 ATP-NAD kinase-like domain
IPR029477 Diacylglycerol kinase type I, N-terminal
IPR000756 Diacylglycerol kinase, accessory domain
IPR001206 Diacylglycerol kinase, catalytic domain
IPR018247 EF-Hand 1, calcium-binding site
IPR002048 EF-hand domain
IPR011992 EF-hand domain pair
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain

UniProt Annotations

Entry Information

Gene Name
diacylglycerol kinase, beta
Protein Entry
DGKB_MOUSE
UniProt ID
Q6NS52
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6NS52-1; Sequence=Displayed; Name=2; IsoId=Q6NS52-2; Sequence=VSP_021900;
Catalytic Activity ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2- diacyl-sn-glycerol 3-phosphate.
Enzyme Regulation Stimulated by phosphatidylserine. {ECO:0000250}.
Function Exhibits high phosphorylation activity for long-chain diacylglycerols. {ECO:0000250}.
Similarity Belongs to the eukaryotic diacylglycerol kinase family. {ECO:0000305}.
Similarity Contains 1 DAGKc domain. {ECO:0000255|PROSITE- ProRule:PRU00783}.
Similarity Contains 2 EF-hand domains. {ECO:0000255|PROSITE- ProRule:PRU00448}.
Similarity Contains 2 phorbol-ester/DAG-type zinc fingers. {ECO:0000255|PROSITE-ProRule:PRU00226}.
Subcellular Location Cytoplasm {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000709 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
83816899 RefSeq NP_848796 795 diacylglycerol kinase beta

Identical Sequences to LMP000709 proteins

Reference Database Accession Length Protein Name
GI:83816899 DBBJ BAE23997.1 795 unnamed protein product [Mus musculus]
GI:83816899 GenBank AAH70461.1 795 Dgkb protein [Mus musculus]
GI:83816899 GenBank ABK42185.1 795 DAGk-beta [synthetic construct]
GI:83816899 RefSeq XP_006515135.1 795 PREDICTED: diacylglycerol kinase beta isoform X6 [Mus musculus]

Related Sequences to LMP000709 proteins

Reference Database Accession Length Protein Name
GI:83816899 RefSeq XP_006515130.1 803 PREDICTED: diacylglycerol kinase beta isoform X1 [Mus musculus]
GI:83816899 RefSeq XP_006515131.1 803 PREDICTED: diacylglycerol kinase beta isoform X2 [Mus musculus]
GI:83816899 RefSeq XP_006515132.1 802 PREDICTED: diacylglycerol kinase beta isoform X3 [Mus musculus]
GI:83816899 RefSeq XP_006515133.1 796 PREDICTED: diacylglycerol kinase beta isoform X4 [Mus musculus]
GI:83816899 RefSeq XP_006515134.1 796 PREDICTED: diacylglycerol kinase beta isoform X5 [Mus musculus]
GI:83816899 SwissProt Q6NS52.2 802 RecName: Full=Diacylglycerol kinase beta; Short=DAG kinase beta; AltName: Full=Diglyceride kinase beta; Short=DGK-beta [Mus musculus]