Gene/Proteome Database (LMPD)

LMPD ID
LMP000714
Gene ID
14731
Species
Mus musculus (Mouse)
Gene Name
GPI anchor attachment protein 1
Gene Symbol
Gpaa1
Synonyms
C80044; mGAA1
Alternate Names
glycosylphosphatidylinositol anchor attachment 1 protein; GAA1 protein homolog
Chromosome
15
Map Location
15|15 E

Proteins

glycosylphosphatidylinositol anchor attachment 1 protein
Refseq ID NP_034461
Protein GI 6754046
UniProt ID Q9WTK3
mRNA ID NM_010331
Length 621
RefSeq Status PROVISIONAL
MGLLSDPVRRRALARIVLRLNTPLCVLSYVAGIAWFLALAFPPLTQRTYMSENAMGSTMVEEQFVGGDRARSFARDFAAHRKKPGALPVAWLERSMRSVGLEVYTQSFSRKLPFPDETHERYMVSGTNVYGILRAPRSASTESLVLTVPCGPDATNSQAVGLLLALAAHFRGQIYWAKDIIFLVTDHDLLGTEAWLEAYHDINVTGIQSSPLQGRAGAIQAAVALELSSDVVTSLDVTVEGLNGQLPNLDLLNLFQTFCQKGGLLCTLQGKLQPQDWTSLEGPLQGLQTLLLMVLRQASGRPHGPHGLFLRYGVEALTLRGINSFRQYKYDLATVGKALEGMFRKLNHLLERLHQSFFFYLLPALSRFVSIGLYMPATGFLLLVLGLKALELWMQLHQAGVNPEEAGKAPSPGTPLLPTQGVGLASLTAPLLISQAMGLALYFLPVLGQHLATQHFPVAEAEAVVLTLLAIYVAGLALPHNTHRVVNSQVPDRGWMALKLVALIYLALQLGCIALLNFSLGFLLAATMVPAAALAKPHGPRTLYAALLVVTSPAVTLFGSLFLWRELLEVPLSLAEGWQLFLTALAQGVLEHYTYGALLFPILALGLYPCWLLFWNVLFWK

Gene Information

Entrez Gene ID
14731
Gene Name
GPI anchor attachment protein 1
Gene Symbol
Gpaa1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0042765 IEA:InterPro C GPI-anchor transamidase complex
GO:0005887 ISS:MGI C integral component of plasma membrane
GO:0034235 IEA:Ensembl F GPI anchor binding
GO:0003923 TAS:MGI F GPI-anchor transamidase activity
GO:0006506 ISS:MGI P GPI anchor biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00563 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
mmu00563 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
mmu01100 Metabolic pathways

REACTOME Pathway Links

REACTOME Pathway ID Description
5893250 Attachment of GPI anchor to uPAR

Domain Information

InterPro Annotations

Accession Description
IPR007246 Gaa1-like, GPI transamidase component
IPR017063 Glycosylphosphatidylinositol:protein transamidase complex, GAA1 component

UniProt Annotations

Entry Information

Gene Name
GPI anchor attachment protein 1
Protein Entry
GPAA1_MOUSE
UniProt ID
Q9WTK3
Species
Mouse

Comments

Comment Type Description
Function Essential for GPI-anchoring of precursor proteins but not for GPI synthesis. Acts before or during formation of the carbonyl intermediate. {ECO:0000269|PubMed:10793132, ECO:0000269|PubMed:10898732}.
Pathway Glycolipid biosynthesis; glycosylphosphatidylinositol- anchor biosynthesis.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Subunit Forms a complex with PIGK/GPI8, PIGT, PIGU and PIGS. {ECO:0000269|PubMed:10793132}.
Tissue Specificity Ubiquitously expressed in fetal and adult tissues. Expressed at higher levels in fetal tissues than adult tissues. In embryos abundant in the choroid plexus, skeletal muscle,. {ECO:0000269|PubMed:10898732}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000714 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6754046 RefSeq NP_034461 621 glycosylphosphatidylinositol anchor attachment 1 protein

Identical Sequences to LMP000714 proteins

Reference Database Accession Length Protein Name
GI:6754046 DBBJ BAC36840.1 621 unnamed protein product [Mus musculus]
GI:6754046 DBBJ BAE37686.1 621 unnamed protein product [Mus musculus]
GI:6754046 DBBJ BAE37988.1 621 unnamed protein product [Mus musculus]
GI:6754046 GenBank AAH06697.1 621 GPI anchor attachment protein 1 [Mus musculus]
GI:6754046 GenBank EDL29548.1 621 GPI anchor attachment protein 1, isoform CRA_b [Mus musculus]
GI:6754046 SwissProt Q9WTK3.3 621 RecName: Full=Glycosylphosphatidylinositol anchor attachment 1 protein; Short=GPI anchor attachment protein 1; AltName: Full=GAA1 protein homolog; Short=mGAA1 [Mus musculus]

Related Sequences to LMP000714 proteins

Reference Database Accession Length Protein Name
GI:6754046 GenBank AAH78984.1 621 Glycosylphosphatidylinositol anchor attachment protein 1 homolog (yeast) [Rattus norvegicus]
GI:6754046 RefSeq NP_001004240.1 621 glycosylphosphatidylinositol anchor attachment 1 protein [Rattus norvegicus]
GI:6754046 RefSeq XP_003507722.1 621 PREDICTED: glycosylphosphatidylinositol anchor attachment 1 protein isoform X2 [Cricetulus griseus]
GI:6754046 RefSeq XP_005086045.1 621 PREDICTED: glycosylphosphatidylinositol anchor attachment 1 protein [Mesocricetus auratus]
GI:6754046 RefSeq XP_005354161.1 621 PREDICTED: glycosylphosphatidylinositol anchor attachment 1 protein [Microtus ochrogaster]
GI:6754046 RefSeq XP_006989393.1 621 PREDICTED: glycosylphosphatidylinositol anchor attachment 1 protein isoform X1 [Peromyscus maniculatus bairdii]