Gene/Proteome Database (LMPD)

LMPD ID
LMP000740
Gene ID
208715
Species
Mus musculus (Mouse)
Gene Name
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1
Gene Symbol
Hmgcs1
Synonyms
B130032C06Rik
Alternate Names
hydroxymethylglutaryl-CoA synthase, cytoplasmic; HMG-CoA synthase; 3-hydroxy-3-methylglutaryl coenzyme A synthase
Chromosome
13
Map Location
13|13
EC Number
2.3.3.10

Proteins

hydroxymethylglutaryl-CoA synthase, cytoplasmic
Refseq ID NP_666054
Protein GI 31981842
UniProt ID Q8JZK9
mRNA ID NM_145942
Length 520
RefSeq Status VALIDATED
MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQARMGFCTDREDINSLCLTVVQKLMERHSLSYDCIGRLEVGTETIIDKSKSVKSNLMQLFEESGNTDIEGIDTTNACYGGTAAVFNAVNWVESSSWDGRYALVVAGDIAIYATGNARPTGGVGAVALLIGPNAPLIFDRGLRGTHMQHAYDFYKPDMLSEYPVVDGKLSIQCYLSALDRCYSVYRKKIRAQWQKEGKDKDFTLNDFGFMIFHSPYCKLVQKSLARMFLNDFLNDQNRDKNSIYSGLEAFGDVKLEDTYFDRDVEKAFMKASSELFNQKTKASLLVSNQNGNMYTSSVYGSLASVLAQYSPQQLAGKRVGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTCVAPDVFAENMKLREDTHHLANYIPQCSIDSLFEGTWYLVRVDEKHRRTYARRPFTNDHSLDEGMGLVHSNTATEHIPSPAKKVPRLPATSAESESAVISNGEH
hydroxymethylglutaryl-CoA synthase, cytoplasmic
Refseq ID NP_001278368
Protein GI 612339316
UniProt ID Q8JZK9
mRNA ID NM_001291439
Length 520
RefSeq Status VALIDATED
Protein sequence is identical to GI:31981842 (mRNA isoform)

Gene Information

Entrez Gene ID
208715
Gene Name
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1
Gene Symbol
Hmgcs1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IEA:Ensembl C cytosol
GO:0005634 IEA:Ensembl C nucleus
GO:0005886 IEA:Ensembl C plasma membrane
GO:0008144 IEA:Ensembl F drug binding
GO:0004421 IEA:UniProtKB-EC F hydroxymethylglutaryl-CoA synthase activity
GO:0016853 IEA:Ensembl F isomerase activity
GO:0043177 IEA:Ensembl F organic acid binding
GO:0007420 IEA:Ensembl P brain development
GO:0071397 IEA:Ensembl P cellular response to cholesterol
GO:0071372 IEA:Ensembl P cellular response to follicle-stimulating hormone stimulus
GO:0006695 IEA:UniProtKB-KW P cholesterol biosynthetic process
GO:0008299 IEA:InterPro P isoprenoid biosynthetic process
GO:0001889 IEA:Ensembl P liver development
GO:0008584 IEA:Ensembl P male gonad development
GO:0001101 IEA:Ensembl P response to acid chemical
GO:0042493 IEA:Ensembl P response to drug
GO:0055094 IEA:Ensembl P response to lipoprotein particle
GO:0009645 IEA:Ensembl P response to low light intensity stimulus
GO:0014074 IEA:Ensembl P response to purine-containing compound
GO:0046690 IEA:Ensembl P response to tellurium ion
GO:0033197 IEA:Ensembl P response to vitamin E

KEGG Pathway Links

KEGG Pathway ID Description
mmu00900 Terpenoid backbone biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR010122 Hydroxymethylglutaryl-CoA synthase, eukaryotic
IPR013746 Hydroxymethylglutaryl-coenzyme A synthase C-terminal domain
IPR013528 Hydroxymethylglutaryl-coenzyme A synthase, N-terminal
IPR000590 Hydroxymethylglutaryl-coenzyme A synthase, active site
IPR016039 Thiolase-like
IPR016038 Thiolase-like, subgroup

UniProt Annotations

Entry Information

Gene Name
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1
Protein Entry
HMCS1_MOUSE
UniProt ID
Q8JZK9
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Acetyl-CoA + H(2)O + acetoacetyl-CoA = (S)-3- hydroxy-3-methylglutaryl-CoA + CoA. {ECO:0000255|PROSITE- ProRule:PRU10116}.
Function This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. {ECO:0000250}.
Pathway Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 2/3.
Similarity Belongs to the HMG-CoA synthase family. {ECO:0000305}.
Subcellular Location Cytoplasm {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000740 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
31981842 RefSeq NP_666054 520 hydroxymethylglutaryl-CoA synthase, cytoplasmic

Identical Sequences to LMP000740 proteins

Reference Database Accession Length Protein Name
GI:31981842 DBBJ BAC32112.1 520 unnamed protein product [Mus musculus]
GI:31981842 DBBJ BAC32218.1 520 unnamed protein product [Mus musculus]
GI:31981842 DBBJ BAE22579.1 520 unnamed protein product [Mus musculus]
GI:31981842 RefSeq XP_006517641.1 520 PREDICTED: hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X3 [Mus musculus]
GI:31981842 RefSeq NP_001278368.1 520 hydroxymethylglutaryl-CoA synthase, cytoplasmic [Mus musculus]
GI:31981842 SwissProt Q8JZK9.1 520 RecName: Full=Hydroxymethylglutaryl-CoA synthase, cytoplasmic; Short=HMG-CoA synthase; AltName: Full=3-hydroxy-3-methylglutaryl coenzyme A synthase [Mus musculus]

Related Sequences to LMP000740 proteins

Reference Database Accession Length Protein Name
GI:31981842 DBBJ BAE22855.1 520 unnamed protein product [Mus musculus]
GI:31981842 GenBank AAH90151.1 520 Unknown (protein for MGC:98430) [Xenopus laevis]
GI:31981842 GenBank EDL18336.1 546 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1, isoform CRA_a, partial [Mus musculus]
GI:31981842 GenBank EDL18337.1 565 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1, isoform CRA_b, partial [Mus musculus]
GI:31981842 RefSeq NP_001184197.1 520 uncharacterized protein LOC100505431 [Xenopus laevis]
GI:31981842 RefSeq XP_006517639.1 549 PREDICTED: hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X1 [Mus musculus]