Gene/Proteome Database (LMPD)

LMPD ID
LMP000742
Gene ID
15492
Species
Mus musculus (Mouse)
Gene Name
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
Gene Symbol
Hsd3b1
Synonyms
D3Ertd383e
Alternate Names
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1; 3-beta-HSD I; hydroxysteroid dehydrogenase-1, delta<5>-3-beta; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I
Chromosome
3
Map Location
3 F2.2|3 42.89 cM
EC Number
1.1.1.145

Proteins

3 beta-hydroxysteroid dehydrogenase/Delta 5--&gt;4-isomerase type 1
Refseq ID NP_032319
Protein GI 6680289
UniProt ID P24815
mRNA ID NM_008293
Length 373
RefSeq Status PROVISIONAL
MAGWSCLVTGAGGFVGQRIIKMLVQEKELQEVRALDKVFRPETKEEFSKLQTKTKVTVLEGDILDAQCLRRACQGISVVIHTAAVIDVTGVIPRQTILDVNLKGTQNLLEACVQASVPAFIFCSSVDVAGPNSYKKIVLNGHEEQNHESTWSDPYPYSKKMAEKAVLAANGSMLKNGGTLNTCALRPMYIYGERSPFIFNAIIRALKNKGILCVTGKFSIANPVYVENVAWAHILAARGLRDPKKSTSIQGQFYYISDDTPHQSYDDLNYTLSKEWGLRPNASWSLPLPLLYWLAFLLETVSFLLRPVYRYRPLFNRHLITLSNSTFTFSYKKAQRDLGYEPLVNWEEAKQKTSEWIGTIVEQHREILDTKCQ

Gene Information

Entrez Gene ID
15492
Gene Name
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
Gene Symbol
Hsd3b1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005739 IDA:MGI C mitochondrion
GO:0003854 IEA:UniProtKB-EC F 3-beta-hydroxy-delta5-steroid dehydrogenase activity
GO:0004769 IEA:UniProtKB-EC F steroid delta-isomerase activity
GO:0006694 IEA:UniProtKB-UniPathway P steroid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu04913 Ovarian steroidogenesis
mmu00140 Steroid hormone biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR002225 3-beta hydroxysteroid dehydrogenase/isomerase
IPR016040 NAD(P)-binding domain

UniProt Annotations

Entry Information

Gene Name
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
Protein Entry
3BHS1_MOUSE
UniProt ID
P24815
Species
Mouse

Comments

Comment Type Description
Catalytic Activity A 3-beta-hydroxy-Delta(5)-steroid + NAD(+) = a 3-oxo-Delta(5)-steroid + NADH.
Catalytic Activity A 3-oxo-Delta(5)-steroid = a 3-oxo-Delta(4)- steroid.
Function 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids.
Pathway Lipid metabolism; steroid biosynthesis.
Similarity Belongs to the 3-beta-HSD family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein.
Tissue Specificity Steroidogenic tissues (includes testes, ovaries and adrenal glands).

Identical and Related Proteins

Unique RefSeq proteins for LMP000742 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6680289 RefSeq NP_032319 373 3 beta-hydroxysteroid dehydrogenase/Delta 5--&gt;4-isomerase type 1

Identical Sequences to LMP000742 proteins

Reference Database Accession Length Protein Name
GI:6680289 DBBJ BAE27686.1 373 unnamed protein product [Mus musculus]
GI:6680289 GenBank AAA37860.1 373 3-beta-hydroxysteroid dehydrogenase/delta-5-steroid isomerase [Mus musculus]
GI:6680289 GenBank EDL38972.1 373 mCG19920 [Mus musculus]
GI:6680289 RefSeq XP_006501098.1 373 PREDICTED: 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 isoform X1 [Mus musculus]
GI:6680289 RefSeq XP_006501099.1 373 PREDICTED: 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 isoform X2 [Mus musculus]
GI:6680289 RefSeq XP_006501100.1 373 PREDICTED: 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 isoform X3 [Mus musculus]

Related Sequences to LMP000742 proteins

Reference Database Accession Length Protein Name
GI:6680289 DBBJ BAE27343.1 435 unnamed protein product, partial [Mus musculus]
GI:6680289 GenBank AAA63474.1 373 3-beta-hydroxysteroid dehydrogenase/delta-5-delta-4 isomerase type I [Rattus norvegicus]
GI:6680289 GenBank AAH52659.1 373 Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 [Mus musculus]
GI:6680289 PRF - 373 hydroxysteroid dehydrogenase/isomerase [Rattus norvegicus]
GI:6680289 RefSeq NP_001007720.3 373 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 [Rattus norvegicus]
GI:6680289 SwissProt P22071.3 373 RecName: Full=3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1; AltName: Full=3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I; Short=3-beta-HSD I; Includes: RecName: Full=3-beta-hydroxy-Delta(5)-steroid dehydrogenase; AltName: Full=3-beta-hydroxy-5-ene steroid dehydrogenase; AltName: Full=Progesterone reductase; Includes: RecName: Full=Steroid Delta-isomerase; AltName: Full=Delta-5-3-ketosteroid isomerase [Rattus norvegicus]