Gene/Proteome Database (LMPD)

LMPD ID
LMP000747
Gene ID
13167
Species
Mus musculus (Mouse)
Gene Name
diazepam binding inhibitor
Gene Symbol
Dbi
Synonyms
ACBD1; Acbp; EP; endozepine
Alternate Names
acyl-CoA-binding protein; acyl-CoA binding protein; diazepam-binding inhibitor; diazepam binding inhibitor, splice form 1b
Chromosome
1
Map Location
1|1 E2

Proteins

acyl-CoA-binding protein isoform 1
Refseq ID NP_001033088
Protein GI 83921595
UniProt ID Q4VWZ5
mRNA ID NM_001037999
Length 135
RefSeq Status VALIDATED
MLWVWGQPGLFPQISRSSSGIRAQLIAWGAELFPLQICKTATHAGTARELPAEFDKAAEEVKRLKTQPTDEEMLFIYSHFKQATVGDVNTDRPGLLDLKGKAKWDSWNKLKGTSKESAMKTYVEKVDELKKKYGI
acyl-CoA-binding protein isoform 2
Refseq ID NP_031856
Protein GI 6681137
UniProt ID P31786
mRNA ID NM_007830
Length 87
RefSeq Status VALIDATED
MSQAEFDKAAEEVKRLKTQPTDEEMLFIYSHFKQATVGDVNTDRPGLLDLKGKAKWDSWNKLKGTSKESAMKTYVEKVDELKKKYGI

Gene Information

Entrez Gene ID
13167
Gene Name
diazepam binding inhibitor
Gene Symbol
Dbi
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0005794 IEA:UniProtKB-KW C Golgi apparatus
GO:0005739 IDA:MGI C mitochondrion
GO:0000062 IEA:InterPro F fatty-acyl-CoA binding
GO:0008289 IEA:UniProtKB-KW F lipid binding
GO:0001942 IMP:MGI P hair follicle development
GO:0043588 IMP:MGI P skin development
GO:0006810 IEA:UniProtKB-KW P transport
GO:0006641 IMP:MGI P triglyceride metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko03320 PPAR signaling pathway
mmu03320 PPAR signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR000582 Acyl-CoA-binding protein, ACBP
IPR022408 Acyl-CoA-binding protein, ACBP, conserved site
IPR014352 FERM/acyl-CoA-binding protein, 3-helical bundle

UniProt Annotations

Entry Information

Gene Name
diazepam binding inhibitor
Protein Entry
Q4VWZ5_MOUSE
UniProt ID
Q4VWZ5
Species
Mouse

Comments

Comment Type Description
Function Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.
Similarity Belongs to the ACBP family. {ECO:0000305}.
Similarity Contains 1 ACB (acyl-CoA-binding) domain. {ECO:0000255|PROSITE-ProRule:PRU00573}.
Subcellular Location Endoplasmic reticulum {ECO:0000250}. Golgi apparatus {ECO:0000250}. Note=Golgi localization is dependent on ligand binding. {ECO:0000250}.
Subunit Monomer.

Identical and Related Proteins

Unique RefSeq proteins for LMP000747 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
83921595 RefSeq NP_001033088 135 acyl-CoA-binding protein isoform 1
6681137 RefSeq NP_031856 87 acyl-CoA-binding protein isoform 2

Identical Sequences to LMP000747 proteins

Reference Database Accession Length Protein Name
GI:6681137 DBBJ BAC25658.1 87 unnamed protein product [Mus musculus]
GI:6681137 DBBJ BAE28656.1 87 unnamed protein product [Mus musculus]
GI:83921595 EMBL CAJ00737.1 135 diazepam binding inhibitor, splice form 1b [Mus musculus]
GI:6681137 GenBank AAH28874.1 87 Diazepam binding inhibitor [Mus musculus]
GI:6681137 GenBank AAP97271.1 87 benzodiazepine receptor ligand [Homo sapiens]
GI:6681137 GenBank EDL39802.1 87 mCG17804, isoform CRA_a [Mus musculus]
GI:83921595 GenBank EDL39803.1 135 mCG17804, isoform CRA_b [Mus musculus]
GI:6681137 GenBank ABS83527.1 87 diazepam binding inhibitor [Mus musculus]

Related Sequences to LMP000747 proteins

Reference Database Accession Length Protein Name
GI:6681137 DBBJ BAE26340.1 87 unnamed protein product [Mus musculus]
GI:83921595 EMBL CAA43673.1 87 diazepam-binding inhibitor [Mus musculus]
GI:83921595 GenBank AAL56658.1 87 diazepam binding inhibitor [Mus musculus]
GI:83921595 GenBank AAH28874.1 87 Diazepam binding inhibitor [Mus musculus]
GI:6681137 GenBank AAH84717.1 87 Diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein) [Rattus norvegicus]
GI:83921595 GenBank EDL39802.1 87 mCG17804, isoform CRA_a [Mus musculus]
GI:83921595 GenBank ABS83527.1 87 diazepam binding inhibitor [Mus musculus]
GI:6681137 GenBank ERE73804.1 87 acyl-CoA-binding protein [Cricetulus griseus]
GI:83921595 RefSeq NP_031856.1 87 acyl-CoA-binding protein isoform 2 [Mus musculus]
GI:6681137 RefSeq XP_003499494.1 87 PREDICTED: acyl-CoA-binding protein [Cricetulus griseus]
GI:6681137 RefSeq XP_005348319.1 87 PREDICTED: acyl-CoA-binding protein isoform X2 [Microtus ochrogaster]
GI:6681137 RefSeq XP_007608376.1 87 PREDICTED: acyl-CoA-binding protein [Cricetulus griseus]