Gene/Proteome Database (LMPD)

LMPD ID
LMP000752
Gene ID
223920
Species
Mus musculus (Mouse)
Gene Name
sterol O-acyltransferase 2
Gene Symbol
Soat2
Synonyms
ACAT2; D15Wsu97e
Alternate Names
sterol O-acyltransferase 2; ACAT-2; cholesterol acyltransferase 2; acyl-CoA:cholesterol acyltransferase; acyl coenzyme A:cholesterol acyltransferase 2; acyl-coenzyme A:cholesterol acyltransferase 2
Chromosome
15
Map Location
15 F3|15 57.33 cM
EC Number
2.3.1.26

Proteins

sterol O-acyltransferase 2
Refseq ID NP_666176
Protein GI 22122547
UniProt ID O88908
mRNA ID NM_146064
Length 525
RefSeq Status PROVISIONAL
MQPKVPQLRRREGLGEEQEKGARGGEGNARTHGTPDLVQWTRHMEAVKTQFLEQAQRELAELLDRALWEAMQAYPKQDRPLPSAAPDSTSKTQELHPGKRKVFITRKSLIDELMEVQHFRTIYHMFIAGLCVLIISTLAIDFIDEGRLMLEFDLLLFSFGQLPLALMTWVPMFLSTLLVPYQTLWLWARPRAGGAWMLGASLGCVLLAAHAVVLCVLPVHVSVRHELPPASRCVLVFEQVRLLMKSYSFLRETVPGIFCVRGGKGISPPSFSSYLYFLFCPTLIYRETYPRTPSIRWNYVAKNFAQVLGCLLYACFILGRLCVPVFANMSREPFSTRALLLSILHATGPGIFMLLLIFFAFLHCWLNAFAEMLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLWLLGRRARGVAMLGVFLVSAVVHEYIFCFVLGFFYPVMLMLFLVFGGLLNFTMNDRHTGPAWNILMWTFLFMGQGIQVSLYCQEWYARRHCPLPQTTFWGMVTPRSWSCHP

Gene Information

Entrez Gene ID
223920
Gene Name
sterol O-acyltransferase 2
Gene Symbol
Soat2
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005903 IEA:Ensembl C brush border
GO:0005789 IEA:Ensembl C endoplasmic reticulum membrane
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0016020 IDA:MGI C membrane
GO:0015485 IEA:Ensembl F cholesterol binding
GO:0034736 IEA:UniProtKB-EC F cholesterol O-acyltransferase activity
GO:0000062 IEA:Ensembl F fatty-acyl-CoA binding
GO:0004772 IDA:MGI F sterol O-acyltransferase activity
GO:0033344 IEA:Ensembl P cholesterol efflux
GO:0034435 IEA:Ensembl P cholesterol esterification
GO:0008203 IDA:MGI P cholesterol metabolic process
GO:0034379 IEA:Ensembl P very-low-density lipoprotein particle assembly

KEGG Pathway Links

KEGG Pathway ID Description
ko00100 Steroid biosynthesis
mmu00100 Steroid biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR004299 Membrane bound O-acyl transferase, MBOAT
IPR014371 Sterol O-acyltransferase, ACAT/DAG/ARE types

UniProt Annotations

Entry Information

Gene Name
sterol O-acyltransferase 2
Protein Entry
SOAT2_MOUSE
UniProt ID
O88908
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Acyl-CoA + cholesterol = CoA + cholesterol ester.
Function Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase. May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa.
Similarity Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein {ECO:0000269|PubMed:11071899}.
Subunit May form homo- or heterodimers. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000752 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
22122547 RefSeq NP_666176 525 sterol O-acyltransferase 2

Identical Sequences to LMP000752 proteins

Reference Database Accession Length Protein Name
GI:22122547 GenBank AAH25931.1 525 Sterol O-acyltransferase 2 [Mus musculus]
GI:22122547 GenBank EDL04004.1 525 sterol O-acyltransferase 2 [Mus musculus]
GI:22122547 SwissProt O88908.2 525 RecName: Full=Sterol O-acyltransferase 2; AltName: Full=Acyl-coenzyme A:cholesterol acyltransferase 2; Short=ACAT-2; AltName: Full=Cholesterol acyltransferase 2 [Mus musculus]

Related Sequences to LMP000752 proteins

Reference Database Accession Length Protein Name
GI:22122547 EMBL CDM22167.1 525 unnamed protein product [Mus musculus]
GI:22122547 GenBank AAC64057.1 525 acyl coenzyme A:cholesterol acyltransferase-2 [Mus musculus]
GI:22122547 GenBank AAQ41961.1 525 Sequence 3 from patent US 6579974
GI:22122547 GenBank EDL86862.1 524 sterol O-acyltransferase 2 [Rattus norvegicus]
GI:22122547 RefSeq NP_714950.2 524 sterol O-acyltransferase 2 [Rattus norvegicus]
GI:22122547 SwissProt Q7TQM4.1 524 RecName: Full=Sterol O-acyltransferase 2; AltName: Full=Acyl-coenzyme A:cholesterol acyltransferase 2; Short=ACAT-2; AltName: Full=Cholesterol acyltransferase 2 [Rattus norvegicus]