Gene/Proteome Database (LMPD)

LMPD ID
LMP000758
Gene ID
19204
Species
Mus musculus (Mouse)
Gene Name
platelet-activating factor receptor
Gene Symbol
Ptafr
Synonyms
PAFR
Alternate Names
platelet-activating factor receptor; PAF-R; PAF receptor
Chromosome
4
Map Location
4 D2.2|4 65.56 cM

Proteins

platelet-activating factor receptor
Refseq ID NP_001074680
Protein GI 124487079
UniProt ID Q62035
mRNA ID NM_001081211
Length 341
RefSeq Status PROVISIONAL
MEHNGSFRVDSEFRYTLFPIVYSVIFILGVVANGYVLWVFANLYPSKKLNEIKIFMVNLTMADLLFLITLPLWIVYYYNEGDWILPNFLCNVAGCLFFINTYCSVAFLGVITYNRYQAVAYPIKTAQATTRKRGISLSLIIWVSIVATASYFLATDSTNLVPNKDGSGNITRCFEHYEPYSVPILVVHVFIAFCFFLVFFLIFYCNLVIIHTLLTQPMRQQRKAGVKRRALWMVCTVLAVFIICFVPHHVVQLPWTLAELGYQTNFHQAINDAHQITLCLLSTNCVLDPVIYCFLTKKFRKHLSEKFYSMRSSRKCSRATSDTCTEVIVPANQTPIVSLKN

Gene Information

Entrez Gene ID
19204
Gene Name
platelet-activating factor receptor
Gene Symbol
Ptafr
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0001530 IMP:MGI F lipopolysaccharide binding
GO:0001875 IMP:MGI F lipopolysaccharide receptor activity
GO:0005543 IEA:Ensembl F phospholipid binding
GO:0004992 IEA:Ensembl F platelet activating factor receptor activity
GO:0006935 IEA:UniProtKB-KW P chemotaxis
GO:0001816 IMP:MGI P cytokine production
GO:0006954 IMP:MGI P inflammatory response
GO:0032959 IMP:MGI P inositol trisphosphate biosynthetic process
GO:0031663 IMP:GOC P lipopolysaccharide-mediated signaling pathway
GO:0048015 IEA:Ensembl P phosphatidylinositol-mediated signaling
GO:0032496 IMP:MGI P response to lipopolysaccharide

KEGG Pathway Links

KEGG Pathway ID Description
mmu04020 Calcium signaling pathway
mmu05150 Staphylococcus aureus infection

Domain Information

InterPro Annotations

Accession Description
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
IPR002282 Platelet-activating factor receptor

UniProt Annotations

Entry Information

Gene Name
platelet-activating factor receptor
Protein Entry
PTAFR_MOUSE
UniProt ID
Q62035
Species
Mouse

Comments

Comment Type Description
Function Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth- muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol- calcium second messenger system.
Induction By lipopolysaccharide (LPS). {ECO:0000269|PubMed:8670084}.
Similarity Belongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}.
Subcellular Location Cell membrane; Multi-pass membrane protein.
Subunit Interacts with ARRB1. {ECO:0000250}.
Tissue Specificity Found in a range of organs. Expressed most strongly in spleen, followed by skeletal muscle, lung and small intestine. Expressed at moderate levels in the heart. Expressed at relatively low levels in the brain, liver and kidney. {ECO:0000269|PubMed:8670084}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000758 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
124487079 RefSeq NP_001074680 341 platelet-activating factor receptor

Identical Sequences to LMP000758 proteins

Reference Database Accession Length Protein Name
GI:124487079 DBBJ BAA09468.1 341 Platelet Activating Factor Receptor [Mus musculus]
GI:124487079 GenBank AAI60361.1 341 Platelet-activating factor receptor [synthetic construct]
GI:124487079 SwissProt Q62035.1 341 RecName: Full=Platelet-activating factor receptor; Short=PAF-R; Short=PAFr [Mus musculus]

Related Sequences to LMP000758 proteins

Reference Database Accession Length Protein Name
GI:124487079 DBBJ BAC27919.1 341 unnamed protein product [Mus musculus]
GI:124487079 GenBank AAA18422.1 341 platelet-activating factor receptor [Rattus norvegicus]
GI:124487079 GenBank ABK42299.1 341 Paf receptor [synthetic construct]
GI:124487079 GenBank EDL30097.1 341 mCG16250 [Mus musculus]
GI:124487079 RefSeq XP_006239125.1 341 PREDICTED: platelet-activating factor receptor isoform X1 [Rattus norvegicus]
GI:124487079 SwissProt P46002.1 341 RecName: Full=Platelet-activating factor receptor; Short=PAF-R; Short=PAFr [Rattus norvegicus]