Gene/Proteome Database (LMPD)

LMPD ID
LMP000759
Gene ID
19214
Species
Mus musculus (Mouse)
Gene Name
prostaglandin D receptor
Gene Symbol
Ptgdr
Synonyms
DP; PGD
Alternate Names
prostaglandin D2 receptor; PGD receptor; PGD2 receptor; prostanoid DP receptor
Chromosome
14
Map Location
14 C1|14 22.59 cM

Proteins

prostaglandin D2 receptor
Refseq ID NP_032988
Protein GI 225543126
UniProt ID P70263
mRNA ID NM_008962
Length 357
RefSeq Status VALIDATED
MNESYRCQTSTWVERGSSATMGAVLFGAGLLGNLLALVLLARSGLGSCRPGPLHPPPSVFYVLVCGLTVTDLLGKCLISPMVLAAYAQNQSLKELLPASGNQLCETFAFLMSFFGLASTLQLLAMAVECWLSLGHPFFYQRHVTLRRGVLVAPVVAAFCLAFCALPFAGFGKFVQYCPGTWCFIQMIHKERSFSVIGFSVLYSSLMALLVLATVVCNLGAMYNLYDMHRRQRHYPHRCSRDRAQSGSDYRHGSLHPLEELDHFVLLALMTVLFTMCSLPLIYRAYYGAFKLENKAEGDSEDLQALRFLSVISIVDPWIFIIFRTSVFRMLFHKVFTRPLIYRNWSSHSQQSNVESTL

Gene Information

Entrez Gene ID
19214
Gene Name
prostaglandin D receptor
Gene Symbol
Ptgdr
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005886 IDA:MGI C plasma membrane
GO:0004956 IDA:MGI F prostaglandin D receptor activity
GO:0001785 IDA:MGI F prostaglandin J receptor activity
GO:0046085 IMP:MGI P adenosine metabolic process
GO:0071799 IMP:MGI P cellular response to prostaglandin D stimulus
GO:0006954 IMP:MGI P inflammatory response
GO:0030238 IMP:MGI P male sex determination
GO:0030431 IMP:MGI P sleep

REACTOME Pathway Links

REACTOME Pathway ID Description
5893265 G alpha (s) signalling events
5893712 Prostanoid ligand receptors

Domain Information

InterPro Annotations

Accession Description
IPR017452 GPCR, rhodopsin-like, 7TM
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000376 Prostaglandin D receptor
IPR008365 Prostanoid receptor

UniProt Annotations

Entry Information

Gene Name
prostaglandin D receptor
Protein Entry
PD2R_MOUSE
UniProt ID
P70263
Species
Mouse

Comments

Comment Type Description
Function Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity). {ECO:0000250}.
Similarity Belongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}.
Subcellular Location Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue Specificity Most abundantly expressed in the ileum, followed by lung, stomach and uterus.

Identical and Related Proteins

Unique RefSeq proteins for LMP000759 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
225543126 RefSeq NP_032988 357 prostaglandin D2 receptor

Identical Sequences to LMP000759 proteins

Reference Database Accession Length Protein Name
GI:225543126 GenBank AAI32298.1 357 Prostaglandin D receptor [Mus musculus]
GI:225543126 GenBank ABP08275.1 357 Sequence 17 from patent US 7183062
GI:225543126 GenBank EDL20681.1 357 prostaglandin D receptor [Mus musculus]
GI:225543126 GenBank ACN08921.1 357 Sequence 17 from patent US 7488799
GI:225543126 GenBank ADL99487.1 357 Sequence 17 from patent US 7723074
GI:225543126 SwissProt P70263.1 357 RecName: Full=Prostaglandin D2 receptor; Short=PGD receptor; Short=PGD2 receptor; AltName: Full=Prostanoid DP receptor [Mus musculus]

Related Sequences to LMP000759 proteins

Reference Database Accession Length Protein Name
GI:225543126 DBBJ BAC27895.1 357 unnamed protein product [Mus musculus]
GI:225543126 GenBank ABP08274.1 357 Sequence 16 from patent US 7183062
GI:225543126 GenBank ADL99486.1 357 Sequence 16 from patent US 7723074
GI:225543126 GenBank AFL01478.1 357 Sequence 2 from patent US 8165517
GI:225543126 RefSeq NP_001128636.1 357 prostaglandin D2 receptor [Rattus norvegicus]
GI:225543126 SwissProt Q9R261.1 357 RecName: Full=Prostaglandin D2 receptor; Short=PGD receptor; Short=PGD2 receptor; AltName: Full=Prostanoid DP receptor [Rattus norvegicus]