Gene/Proteome Database (LMPD)

LMPD ID
LMP000760
Gene ID
7376
Species
Homo sapiens (Human)
Gene Name
nuclear receptor subfamily 1, group H, member 2
Gene Symbol
NR1H2
Synonyms
LXR-b; LXRB; NER; NER-I; RIP15; UNR
Chromosome
19
Map Location
19q13.3
Summary
The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).[supplied by OMIM, Jan 2010]
Orthologs
View orthologs and multiple alignments for NR1H2

Proteins

oxysterols receptor LXR-beta isoform 1
Refseq ID NP_009052
Protein GI 85362735
UniProt ID P55055
mRNA ID NM_007121
Length 461
RefSeq Status VALIDATED
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
oxysterols receptor LXR-beta isoform 2
Refseq ID NP_001243576
Protein GI 375331888
UniProt ID P55055
mRNA ID NM_001256647
Length 364
RefSeq Status VALIDATED
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWGVLSEEQIRKKKIRKQQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE

Gene Information

Entrez Gene ID
7376
Gene Name
nuclear receptor subfamily 1, group H, member 2
Gene Symbol
NR1H2
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:HGNC C cytoplasm
GO:0005654 TAS:Reactome C nucleoplasm
GO:0005634 IDA:HGNC C nucleus
GO:0051117 IPI:BHF-UCL F ATPase binding
GO:0003677 TAS:ProtInc F DNA binding
GO:0000978 IDA:NTNU_SB F RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 IDA:NTNU_SB F RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0034191 IPI:BHF-UCL F apolipoprotein A-I receptor binding
GO:0004879 TAS:ProtInc F ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001133 IEA:Ensembl F sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity
GO:0003707 IEA:InterPro F steroid hormone receptor activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0044255 IEA:Ensembl P cellular lipid metabolic process
GO:0010467 TAS:Reactome P gene expression
GO:0010887 IMP:BHF-UCL P negative regulation of cholesterol storage
GO:0060336 NAS:BHF-UCL P negative regulation of interferon-gamma-mediated signaling pathway
GO:0032369 IMP:BHF-UCL P negative regulation of lipid transport
GO:0010745 IC:BHF-UCL P negative regulation of macrophage derived foam cell differentiation
GO:0048550 IMP:BHF-UCL P negative regulation of pinocytosis
GO:0045892 IDA:HGNC P negative regulation of transcription, DNA-templated
GO:0032270 IMP:BHF-UCL P positive regulation of cellular protein metabolic process
GO:0010875 IMP:BHF-UCL P positive regulation of cholesterol efflux
GO:0032376 IDA:BHF-UCL P positive regulation of cholesterol transport
GO:0045723 IMP:BHF-UCL P positive regulation of fatty acid biosynthetic process
GO:0051006 IMP:BHF-UCL P positive regulation of lipoprotein lipase activity
GO:0045944 IDA:UniProtKB P positive regulation of transcription from RNA polymerase II promoter
GO:0010867 IMP:BHF-UCL P positive regulation of triglyceride biosynthetic process
GO:2000188 ISS:UniProtKB P regulation of cholesterol homeostasis
GO:0048384 IEA:Ensembl P retinoic acid receptor signaling pathway
GO:0006367 TAS:Reactome P transcription initiation from RNA polymerase II promoter

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_12627 Generic Transcription Pathway
REACT_15525 Nuclear Receptor transcription pathway

Domain Information

InterPro Annotations

Accession Description
IPR023257 Liver X receptor
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001723 Steroid hormone receptor
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
nuclear receptor subfamily 1, group H, member 2
Protein Entry
NR1H2_HUMAN
UniProt ID
P55055
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P55055-1; Sequence=Displayed; Name=2; IsoId=P55055-2; Sequence=VSP_053789; Note=No experimental confirmation.;
Function Nuclear receptor. Binds preferentially to double- stranded oligonucleotide direct repeats having the consensus half- site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity).
Interaction O95477:ABCA1; NbExp=2; IntAct=EBI-745354, EBI-784112; Q99750:MDFI; NbExp=3; IntAct=EBI-745354, EBI-724076;
Similarity Belongs to the nuclear hormone receptor family. NR1 subfamily.
Similarity Contains 1 nuclear receptor DNA-binding domain.
Subcellular Location Nucleus {ECO
Subunit Forms a heterodimer with RXR.
Tissue Specificity Ubiquitous.

Identical and Related Proteins

Unique RefSeq proteins for LMP000760 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
85362735 RefSeq NP_009052 461 oxysterols receptor LXR-beta isoform 1
375331888 RefSeq NP_001243576 364 oxysterols receptor LXR-beta isoform 2

Identical Sequences to LMP000760 proteins

Reference Database Accession Length Protein Name
GI:375331888 GenBank EAW71850.1 364 nuclear receptor subfamily 1, group H, member 2, isoform CRA_a [Homo sapiens]
GI:85362735 GenBank JAA23233.1 461 nuclear receptor subfamily 1, group H, member 2 [Pan troglodytes]
GI:85362735 GenBank JAA35318.1 461 nuclear receptor subfamily 1, group H, member 2 [Pan troglodytes]
GI:85362735 GenBank AHD75255.1 461 Sequence 16534 from patent US 8586006
GI:375331888 RefSeq XP_003813669.1 364 PREDICTED: oxysterols receptor LXR-beta isoform X2 [Pan paniscus]
GI:85362735 RefSeq XP_004061275.1 461 PREDICTED: oxysterols receptor LXR-beta isoform 1 [Gorilla gorilla gorilla]
GI:375331888 RefSeq XP_004061276.1 364 PREDICTED: oxysterols receptor LXR-beta isoform 2 [Gorilla gorilla gorilla]
GI:85362735 RefSeq XP_008964388.1 461 PREDICTED: oxysterols receptor LXR-beta isoform X1 [Pan paniscus]
GI:85362735 RefSeq XP_009434358.1 461 PREDICTED: oxysterols receptor LXR-beta [Pan troglodytes]

Related Sequences to LMP000760 proteins

Reference Database Accession Length Protein Name
GI:85362735 EMBL CAG32987.1 461 NR1H2 [Homo sapiens]
GI:85362735 GenBank AAS26150.1 461 Sequence 655 from patent US 6673549
GI:85362735 GenBank AAX29334.1 462 nuclear receptor subfamily 1 group H member 2, partial [synthetic construct]
GI:85362735 GenBank AAX36229.1 461 nuclear receptor subfamily 1 group H member 2 [synthetic construct]
GI:85362735 GenBank ACM82219.1 478 Sequence 7717 from patent US 6812339
GI:85362735 GenBank AIC55291.1 461 NR1H2, partial [synthetic construct]
GI:375331888 RefSeq XP_004381755.1 357 PREDICTED: oxysterols receptor LXR-beta isoform 2 [Trichechus manatus latirostris]
GI:375331888 RefSeq XP_004767278.1 361 PREDICTED: oxysterols receptor LXR-beta isoform X3 [Mustela putorius furo]
GI:375331888 RefSeq XP_004811647.1 361 PREDICTED: oxysterols receptor LXR-beta isoform X3 [Mustela putorius furo]
GI:375331888 RefSeq XP_005412851.1 371 PREDICTED: oxysterols receptor LXR-beta isoform X4 [Chinchilla lanigera]
GI:375331888 RefSeq XP_005590062.1 364 PREDICTED: oxysterols receptor LXR-beta isoform X2 [Macaca fascicularis]
GI:375331888 RefSeq XP_005616329.1 358 PREDICTED: oxysterols receptor LXR-beta isoform X4 [Canis lupus familiaris]