Gene/Proteome Database (LMPD)

LMPD ID
LMP000765
Gene ID
64064
Species
Homo sapiens (Human)
Gene Name
3-oxoacid CoA transferase 2
Gene Symbol
OXCT2
Synonyms
SCOTT
Alternate Names
succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial; 3-oxoacid CoA-transferase 2A; 3-oxoacid-CoA transferase 2A; testis-specific succinyl CoA:3-oxoacid CoA-transferase; testis-specific succinyl-CoA:3-oxoacid CoA-transferase; succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial
Chromosome
1
Map Location
1p34
EC Number
2.8.3.5
Summary
OXCT2 is a testis-specific succinyl-CoA:3-oxoacid CoA transferase (EC 2.8.3.5), which catalyzes the reversible transfer of CoA from succinyl-CoA to acetoacetate in the first step of ketone body utilization. See also OXCT1 (MIM 601424).[supplied by OMIM, Mar 2008]
Orthologs
View orthologs and multiple alignments for OXCT2

Proteins

succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial precursor
Refseq ID NP_071403
Protein GI 11545841
UniProt ID Q9BYC2
mRNA ID NM_022120
Length 517
RefSeq Status PROVISIONAL
MAALRLLASVLGRGVPAGGSGLALSQGCARCFATSPRLRAKFYADPVEMVKDISDGATVMIGGFGLCGIPENLIAALLRTRVKDLQVVSSNVGVEDFGLGLLLAARQVRRIVCSYVGENTLCESQYLAGELELELTPQGTLAERIRAGGAGVPAFYTPTGYGTLVQEGGAPIRYTPDGHLALMSQPREVREFNGDHFLLERAIRADFALVKGWKADRAGNVVFRRSARNFNVPMCKAADVTAVEVEEIVEVGAFPPEDIHVPNIYVDRVIKGQKYEKRIERLTILKEEDGDAGKEEDARTRIIRRAALEFEDGMYANLGIGIPLLASNFISPSMTVHLHSENGILGLGPFPTEDEVDADLINAGKQTVTVLPGGCFFASDDSFAMIRGGHIQLTMLGAMQVSKYGDLANWMIPGKKVKGMGGAMDLVSSQKTRVVVTMQHCTKDNTPKIMEKCTMPLTGKRCVDRIITEKAVFDVHRKKELTLRELWEGLTVDDIKKSTGCAFAVSPNLRPMQQVAP
transit_peptide: 1..39 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (Q9BYC2.2) calculated_mol_wt: 3886 peptide sequence: MAALRLLASVLGRGVPAGGSGLALSQGCARCFATSPRLR mat_peptide: 40..517 product: Succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q9BYC2.2) calculated_mol_wt: 52273 peptide sequence: AKFYADPVEMVKDISDGATVMIGGFGLCGIPENLIAALLRTRVKDLQVVSSNVGVEDFGLGLLLAARQVRRIVCSYVGENTLCESQYLAGELELELTPQGTLAERIRAGGAGVPAFYTPTGYGTLVQEGGAPIRYTPDGHLALMSQPREVREFNGDHFLLERAIRADFALVKGWKADRAGNVVFRRSARNFNVPMCKAADVTAVEVEEIVEVGAFPPEDIHVPNIYVDRVIKGQKYEKRIERLTILKEEDGDAGKEEDARTRIIRRAALEFEDGMYANLGIGIPLLASNFISPSMTVHLHSENGILGLGPFPTEDEVDADLINAGKQTVTVLPGGCFFASDDSFAMIRGGHIQLTMLGAMQVSKYGDLANWMIPGKKVKGMGGAMDLVSSQKTRVVVTMQHCTKDNTPKIMEKCTMPLTGKRCVDRIITEKAVFDVHRKKELTLRELWEGLTVDDIKKSTGCAFAVSPNLRPMQQVAP

Gene Information

Entrez Gene ID
64064
Gene Name
3-oxoacid CoA transferase 2
Gene Symbol
OXCT2
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005739 IDA:MGI C mitochondrion
GO:0031514 IDA:MGI C motile cilium
GO:0008260 IEA:UniProtKB-EC F 3-oxoacid CoA-transferase activity
GO:0046952 IEA:InterPro P ketone body catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa00650 Butanoate metabolism
ko00650 Butanoate metabolism
hsa00072 Synthesis and degradation of ketone bodies
hsa00280 Valine, leucine and isoleucine degradation

Domain Information

InterPro Annotations

Accession Description
IPR014388 3-oxoacid_CoA-transferase
IPR012792 3-oxoacid CoA-transferase, subunit A
IPR012791 3-oxoacid CoA-transferase, subunit B
IPR004164 Coenzyme A transferase active site
IPR004163 Coenzyme A transferase binding site
IPR004165 Coenzyme A transferase family I

UniProt Annotations

Entry Information

Gene Name
3-oxoacid CoA transferase 2
Protein Entry
SCOT2_HUMAN
UniProt ID
Q9BYC2
Species
Human

Comments

Comment Type Description
Catalytic Activity Succinyl-CoA + a 3-oxo acid = succinate + a 3- oxoacyl-CoA.
Function Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity).
Pathway Ketone metabolism; succinyl-CoA degradation; acetoacetyl- CoA from succinyl-CoA
Similarity Belongs to the 3-oxoacid CoA-transferase family.
Subcellular Location Mitochondrion .
Subunit Homodimer.
Tissue Specificity Testis specific.

Identical and Related Proteins

Unique RefSeq proteins for LMP000765 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
11545841 RefSeq NP_071403 517 succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial precursor

Identical Sequences to LMP000765 proteins

Reference Database Accession Length Protein Name
GI:11545841 EMBL CBH19406.1 517 unnamed protein product [Homo sapiens]
GI:11545841 GenBank ADC20551.1 517 Sequence 1035 from patent US 7638288
GI:11545841 GenBank ADT54690.1 517 Sequence 169 from patent US 7842783
GI:11545841 GenBank AEP61133.1 517 Sequence 127 from patent US 8026065
GI:11545841 GenBank AGD01512.1 517 Sequence 1035 from patent US 8338124
GI:11545841 GenBank AHD79506.1 517 Sequence 29150 from patent US 8586006

Related Sequences to LMP000765 proteins

Reference Database Accession Length Protein Name
GI:11545841 DBBJ BAG52651.1 517 unnamed protein product [Homo sapiens]
GI:11545841 GenBank ABA67767.1 517 Sequence 3409 from patent US 6943241
GI:11545841 GenBank ABM84266.1 513 3-oxoacid CoA transferase 2 [synthetic construct]
GI:11545841 GenBank ABM87659.1 513 3-oxoacid CoA transferase 2, partial [synthetic construct]
GI:11545841 GenBank AIC58597.1 513 OXCT2, partial [synthetic construct]
GI:11545841 RefSeq XP_009452733.1 517 PREDICTED: LOW QUALITY PROTEIN: succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial [Pan troglodytes]