Gene/Proteome Database (LMPD)
LMPD ID
LMP000772
Gene ID
Species
Homo sapiens (Human)
Gene Name
solute carrier organic anion transporter family, member 2A1
Gene Symbol
Synonyms
MATR1; OATP2A1; PGT; PHOAR2; SLC21A2
Alternate Names
solute carrier organic anion transporter family member 2A1; matrin F/G 1; solute carrier family 21 (prostaglandin transporter), member 2
Chromosome
3
Map Location
3q21
Summary
This gene encodes a prostaglandin transporter that is a member of the 12-membrane-spanning superfamily of transporters. The encoded protein may be involved in mediating the uptake and clearance of prostaglandins in numerous tissues. [provided by RefSeq, Dec 2011]
Orthologs
Proteins
| solute carrier organic anion transporter family member 2A1 | |
|---|---|
| Refseq ID | NP_005621 |
| Protein GI | 188528663 |
| UniProt ID | Q92959 |
| mRNA ID | NM_005630 |
| Length | 643 |
| RefSeq Status | REVIEWED |
| MGLLPKLGASQGSDTSTSRAGRCARSVFGNIKVFVLCQGLLQLCQLLYSAYFKSSLTTIEKRFGLSSSSSGLISSLNEISNAILIIFVSYFGSRVHRPRLIGIGGLFLAAGAFILTLPHFLSEPYQYTLASTGNNSRLQAELCQKHWQDLPPSKCHSTTQNPQKETSSMWGLMVVAQLLAGIGTVPIQPFGISYVDDFSEPSNSPLYISILFAISVFGPAFGYLLGSVMLQIFVDYGRVNTAAVNLVPGDPRWIGAWWLGLLISSALLVLTSFPFFFFPRAMPIGAKRAPATADEARKLEEAKSRGSLVDFIKRFPCIFLRLLMNSLFVLVVLAQCTFSSVIAGLSTFLNKFLEKQYGTSAAYANFLIGAVNLPAAALGMLFGGILMKRFVFSLQAIPRIATTIITISMILCVPLFFMGCSTPTVAEVYPPSTSSSIHPQSPACRRDCSCPDSIFHPVCGDNGIEYLSPCHAGCSNINMSSATSKQLIYLNCSCVTGGSASAKTGSCPVPCAHFLLPAIFLISFVSLIACISHNPLYMMVLRVVNQEEKSFAIGVQFLLMRLLAWLPSPALYGLTIDHSCIRWNSLCLGRRGACAYYDNDALRDRYLGLQMGYKALGMLLLCFISWRVKKNKEYNVQKAAGLI | |
Gene Information
Entrez Gene ID
Gene Name
solute carrier organic anion transporter family, member 2A1
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005887 | TAS:ProtInc | C | integral component of plasma membrane |
| GO:0016020 | TAS:ProtInc | C | membrane |
| GO:0005886 | TAS:Reactome | C | plasma membrane |
| GO:0005319 | TAS:ProtInc | F | lipid transporter activity |
| GO:0015132 | IEA:Ensembl | F | prostaglandin transmembrane transporter activity |
| GO:0006869 | TAS:ProtInc | P | lipid transport |
| GO:0043252 | TAS:Reactome | P | sodium-independent organic anion transport |
| GO:0055085 | TAS:Reactome | P | transmembrane transport |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_19118 | SLC-mediated transmembrane transport |
| REACT_15518 | Transmembrane transport of small molecules |
| REACT_23988 | Transport of organic anions |
| REACT_22285 | Transport of vitamins, nucleosides, and related molecules |
Domain Information
UniProt Annotations
Entry Information
Gene Name
solute carrier organic anion transporter family, member 2A1
Protein Entry
SO2A1_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Disease | Hypertrophic osteoarthropathy, primary, autosomal recessive, 2 (PHOAR2) [MIM |
| Function | May mediate the release of newly synthesized prostaglandins from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Transports PGD2, as well as PGE1, PGE2 and PGF2A. |
| Interaction | P62993:GRB2; NbExp=1; IntAct=EBI-1760532, EBI-401755; |
| Similarity | Belongs to the organo anion transporter (TC 2.A.60) family. |
| Similarity | Contains 1 Kazal-like domain. {ECO |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | Ubiquitous. Significant expression observed in ling, kidney, spleen, and heart. |
| Web Resource | Name=Solute carrier organic anion transporter family, member 2A1 (SLCO2A1); Note=Leiden Open Variation Database (LOVD); URL="http://www.lovd.nl/SLCO2A1"; |
Identical and Related Proteins
Unique RefSeq proteins for LMP000772 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 188528663 | RefSeq | NP_005621 | 643 | solute carrier organic anion transporter family member 2A1 |
Identical Sequences to LMP000772 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:188528663 | GenBank | AAE20798.1 | 643 | Sequence 39 from patent US 5849578 |
| GI:188528663 | GenBank | AAH51347.1 | 643 | Solute carrier organic anion transporter family, member 2A1 [Homo sapiens] |
| GI:188528663 | GenBank | AAH41140.2 | 643 | Solute carrier organic anion transporter family, member 2A1 [Homo sapiens] |
| GI:188528663 | GenBank | EAW79156.1 | 643 | solute carrier organic anion transporter family, member 2A1 [Homo sapiens] |
| GI:188528663 | GenBank | AIC49744.1 | 643 | SLCO2A1, partial [synthetic construct] |
| GI:188528663 | SwissProt | Q92959.2 | 643 | RecName: Full=Solute carrier organic anion transporter family member 2A1; AltName: Full=Prostaglandin transporter; Short=PGT; AltName: Full=Solute carrier family 21 member 2 [Homo sapiens] |
Related Sequences to LMP000772 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:188528663 | GenBank | AAC09469.1 | 643 | prostaglandin transporter hPGT [Homo sapiens] |
| GI:188528663 | GenBank | AAC62004.1 | 643 | prostaglandin transporter [Homo sapiens] |
| GI:188528663 | GenBank | AAS36978.1 | 643 | Sequence 28 from patent US 6692934 |
| GI:188528663 | GenBank | ABU31470.1 | 643 | Sequence 28 from patent US 7235375 |
| GI:188528663 | GenBank | ACM81147.1 | 643 | Sequence 6645 from patent US 6812339 |
| GI:188528663 | GenBank | AHD78668.1 | 643 | Sequence 26666 from patent US 8586006 |