Gene/Proteome Database (LMPD)
LMPD ID
LMP000776
Gene ID
Species
Homo sapiens (Human)
Gene Name
phosphatidylinositol transfer protein, cytoplasmic 1
Gene Symbol
Synonyms
M-RDGB-beta; MRDGBbeta; RDGB-BETA; RDGBB; RDGBB1
Alternate Names
cytoplasmic phosphatidylinositol transfer protein 1; M-rdgB beta; mammalian rdgB homolog beta; retinal degeneration B beta 1; retinal degeneration B homolog beta
Chromosome
17
Map Location
17q24.2
Summary
This gene encodes a member of the phosphatidylinositol transfer protein family. The encoded cytoplasmic protein plays a role in multiple processes including cell signaling and lipid metabolism by facilitating the transfer of phosphatidylinositol between membrane compartments. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 1. [provided by RefSeq, May 2012]
Orthologs
Proteins
| cytoplasmic phosphatidylinositol transfer protein 1 isoform a | |
|---|---|
| Refseq ID | NP_036549 |
| Protein GI | 32307140 |
| UniProt ID | Q9UKF7 |
| mRNA ID | NM_012417 |
| Length | 332 |
| RefSeq Status | REVIEWED |
| MLLKEYRICMPLTVDEYKIGQLYMISKHSHEQSDRGEGVEVVQNEPFEDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYTCSFLPKFSIHIETKYEDNKGSNDTIFDNEAKDVEREVCFIDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQFVHKVVRDILLIGHRQAFAWVDEWYDMTMDEVREFERATQEATNKKIGIFPPAISISSIPLLPSSVRSAPSSAPSTPLSTDAPEFLSVPKDRPRKKSAPETLTLPDPEKKATLNLPGMHSSDKPCRPKSE | |
| cytoplasmic phosphatidylinositol transfer protein 1 isoform b | |
|---|---|
| Refseq ID | NP_858057 |
| Protein GI | 32307142 |
| UniProt ID | Q9UKF7 |
| mRNA ID | NM_181671 |
| Length | 268 |
| RefSeq Status | REVIEWED |
| MLLKEYRICMPLTVDEYKIGQLYMISKHSHEQSDRGEGVEVVQNEPFEDPHHGNGQFTEKRVYLNSKLPSWARAVVPKIFYVTEKAWNYYPYTITEYTCSFLPKFSIHIETKYEDNKGSNDTIFDNEAKDVEREVCFIDIACDEIPERYYKESEDPKHFKSEKTGRGQLREGWRDSHQPIMCSYKLVTVKFEVWGLQTRVEQFVHKVVRDILLIGHRQAFAWVDEWYDMTMDDVREYEKNMHEQTNIKVCNQHSSPVDDIESHAQTST | |
Gene Information
Entrez Gene ID
Gene Name
phosphatidylinositol transfer protein, cytoplasmic 1
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005737 | IDA:UniProtKB | C | cytoplasm |
| GO:0008289 | IEA:UniProtKB-KW | F | lipid binding |
| GO:0008526 | IMP:UniProtKB | F | phosphatidylinositol transporter activity |
| GO:0015914 | IMP:GOC | P | phospholipid transport |
| GO:0007165 | IMP:UniProtKB | P | signal transduction |
Domain Information
UniProt Annotations
Entry Information
Gene Name
phosphatidylinositol transfer protein, cytoplasmic 1
Protein Entry
PITC1_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9UKF7-1; Sequence=Displayed; Name=2; IsoId=Q9UKF7-2; Sequence=VSP_025545; Note=No experimental confirmation available.; |
| Function | Phosphatidylinositol transfer proteins mediate the monomeric transport of lipids by shielding a lipid from the aqueous environment and binding the lipid in a hydrophobic cavity. Able to transfer phosphatidylinositol in vitro. |
| Interaction | Q6RW13:AGTRAP; NbExp=3; IntAct=EBI-749241, EBI-741181; |
| Similarity | Belongs to the PtdIns transfer protein family. PI transfer class IIB subfamily. |
| Subcellular Location | Cytoplasm . |
| Tissue Specificity | Ubiquitously expressed. |
Identical and Related Proteins
Unique RefSeq proteins for LMP000776 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 32307140 | RefSeq | NP_036549 | 332 | cytoplasmic phosphatidylinositol transfer protein 1 isoform a |
| 32307142 | RefSeq | NP_858057 | 268 | cytoplasmic phosphatidylinositol transfer protein 1 isoform b |
Identical Sequences to LMP000776 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:32307142 | GenBank | JAA02575.1 | 268 | phosphatidylinositol transfer protein, cytoplasmic 1 [Pan troglodytes] |
| GI:32307142 | GenBank | JAA13451.1 | 268 | phosphatidylinositol transfer protein, cytoplasmic 1 [Pan troglodytes] |
| GI:32307142 | GenBank | JAA29411.1 | 268 | phosphatidylinositol transfer protein, cytoplasmic 1 [Pan troglodytes] |
| GI:32307142 | GenBank | JAA33849.1 | 268 | phosphatidylinositol transfer protein, cytoplasmic 1 [Pan troglodytes] |
| GI:32307142 | GenBank | AIC51121.1 | 268 | PITPNC1, partial [synthetic construct] |
| GI:32307140 | RefSeq | XP_001164285.1 | 332 | PREDICTED: cytoplasmic phosphatidylinositol transfer protein 1 isoform X2 [Pan troglodytes] |
| GI:32307142 | RefSeq | XP_003812407.1 | 268 | PREDICTED: cytoplasmic phosphatidylinositol transfer protein 1 isoform X2 [Pan paniscus] |
| GI:32307140 | RefSeq | XP_008962996.1 | 332 | PREDICTED: cytoplasmic phosphatidylinositol transfer protein 1 isoform X1 [Pan paniscus] |
| GI:32307140 | RefSeq | XP_008962997.1 | 332 | PREDICTED: cytoplasmic phosphatidylinositol transfer protein 1 isoform X1 [Pan paniscus] |
| GI:32307140 | RefSeq | XP_009431378.1 | 332 | PREDICTED: cytoplasmic phosphatidylinositol transfer protein 1 isoform X2 [Pan troglodytes] |
| GI:32307140 | SwissProt | Q9UKF7.3 | 332 | RecName: Full=Cytoplasmic phosphatidylinositol transfer protein 1; AltName: Full=Mammalian rdgB homolog beta; Short=M-rdgB beta; Short=MrdgBbeta; AltName: Full=Retinal degeneration B homolog beta; Short=RdgBbeta [Homo sapiens] |
Related Sequences to LMP000776 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:32307142 | DBBJ | BAF83527.1 | 268 | unnamed protein product [Homo sapiens] |
| GI:32307140 | GenBank | AAF06148.1 | 332 | retinal degeneration B beta [Homo sapiens] |
| GI:32307142 | GenBank | JAB22232.1 | 268 | cytoplasmic phosphatidylinositol transfer protein 1 isoform b [Callithrix jacchus] |
| GI:32307142 | GenBank | JAB31418.1 | 268 | cytoplasmic phosphatidylinositol transfer protein 1 isoform b [Callithrix jacchus] |
| GI:32307142 | RefSeq | XP_003276115.1 | 268 | PREDICTED: cytoplasmic phosphatidylinositol transfer protein 1 isoform 1 [Nomascus leucogenys] |
| GI:32307140 | RefSeq | XP_003276116.1 | 332 | PREDICTED: cytoplasmic phosphatidylinositol transfer protein 1 isoform 2 [Nomascus leucogenys] |
| GI:32307142 | RefSeq | XP_003913377.1 | 268 | PREDICTED: cytoplasmic phosphatidylinositol transfer protein 1 isoform X5 [Papio anubis] |
| GI:32307140 | RefSeq | XP_003913378.1 | 332 | PREDICTED: cytoplasmic phosphatidylinositol transfer protein 1 isoform X1 [Papio anubis] |
| GI:32307140 | RefSeq | XP_004432727.1 | 332 | PREDICTED: cytoplasmic phosphatidylinositol transfer protein 1 isoform 1 [Ceratotherium simum simum] |
| GI:32307140 | RefSeq | XP_006146833.1 | 332 | PREDICTED: cytoplasmic phosphatidylinositol transfer protein 1 isoform X1 [Tupaia chinensis] |
| GI:32307140 | RefSeq | XP_008010206.1 | 332 | PREDICTED: cytoplasmic phosphatidylinositol transfer protein 1 isoform X3 [Chlorocebus sabaeus] |
| GI:32307142 | RefSeq | XP_008010213.1 | 268 | PREDICTED: cytoplasmic phosphatidylinositol transfer protein 1 isoform X9 [Chlorocebus sabaeus] |