Gene/Proteome Database (LMPD)

LMPD ID
LMP000789
Gene ID
94005
Species
Homo sapiens (Human)
Gene Name
phosphatidylinositol glycan anchor biosynthesis, class S
Gene Symbol
PIGS
Synonyms
-
Chromosome
17
Map Location
17p13.2
Summary
This gene encodes a protein that is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes an essential component of the multisubunit enzyme, GPI transamidase. GPI transamidase mediates GPI anchoring in the endoplasmic reticulum, by catalyzing the transfer of fully assembled GPI units to proteins. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for PIGS

Proteins

GPI transamidase component PIG-S
Refseq ID NP_149975
Protein GI 15088795
UniProt ID Q8NBL9
mRNA ID NM_033198
Length 555
RefSeq Status REVIEWED
MAAAGAAATHLEVARGKRAALFFAAVAIVLGLPLWWKTTETYRASLPYSQISGLNALQLRLMVPVTVVFTRESVPLDDQEKLPFTVVHEREIPLKYKMKIKCRFQKAYRRALDHEEEALSSGSVQEAEAMLDEPQEQAEGSLTVYVISEHSSLLPQDMMSYIGPKRTAVVRGIMHREAFNIIGRRIVQVAQAMSLTEDVLAAALADHLPEDKWSAEKRRPLKSSLGYEITFSLLNPDPKSHDVYWDIEGAVRRYVQPFLNALGAAGNFSVDSQILYYAMLGVNPRFDSASSSYYLDMHSLPHVINPVESRLGSSAASLYPVLNFLLYVPELAHSPLYIQDKDGAPVATNAFHSPRWGGIMVYNVDSKTYNASVLPVRVEVDMVRVMEVFLAQLRLLFGIAQPQLPPKCLLSGPTSEGLMTWELDRLLWARSVENLATATTTLTSLAQLLGKISNIVIKDDVASEVYKAVAAVQKSAEELASGHLASAFVASQEAVTSSELAFFDPSLLHLLYFPDDQKFAIYIPLFLPMAVPILLSLVKIFLETRKSWRKPEKTD

Gene Information

Entrez Gene ID
94005
Gene Name
phosphatidylinositol glycan anchor biosynthesis, class S
Gene Symbol
PIGS
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0042765 IEA:InterPro C GPI-anchor transamidase complex
GO:0016255 IEA:InterPro P attachment of GPI anchor to protein

KEGG Pathway Links

KEGG Pathway ID Description
hsa00563 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
ko00563 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
hsa01100 Metabolic pathways

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_1830 Attachment of GPI anchor to uPAR

Domain Information

InterPro Annotations

Accession Description
IPR019540 Phosphatidylinositol-glycan biosynthesis class S protein

UniProt Annotations

Entry Information

Gene Name
phosphatidylinositol glycan anchor biosynthesis, class S
Protein Entry
PIGS_HUMAN
UniProt ID
Q8NBL9
Species
Human

Identical and Related Proteins

Unique RefSeq proteins for LMP000789 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
15088795 RefSeq NP_149975 555 GPI transamidase component PIG-S

Identical Sequences to LMP000789 proteins

Reference Database Accession Length Protein Name
GI:15088795 DBBJ BAI45805.1 555 phosphatidylinositol glycan anchor biosynthesis, class S, partial [synthetic construct]
GI:15088795 EMBL CAH05658.1 555 unnamed protein product [Homo sapiens]
GI:15088795 GenBank AAH69228.1 555 Phosphatidylinositol glycan anchor biosynthesis, class S [Homo sapiens]
GI:15088795 GenBank EAW51102.1 555 phosphatidylinositol glycan, class S, isoform CRA_c [Homo sapiens]
GI:15088795 GenBank AHD77303.1 555 Sequence 22436 from patent US 8586006
GI:15088795 SwissProt Q96S52.3 555 RecName: Full=GPI transamidase component PIG-S; AltName: Full=Phosphatidylinositol-glycan biosynthesis class S protein [Homo sapiens]

Related Sequences to LMP000789 proteins

Reference Database Accession Length Protein Name
GI:15088795 DBBJ BAC11615.1 555 unnamed protein product [Homo sapiens]
GI:15088795 DBBJ BAG37159.1 555 unnamed protein product [Homo sapiens]
GI:15088795 EMBL CAC39743.1 555 unnamed protein product [Homo sapiens]
GI:15088795 EMBL CAH05657.1 555 unnamed protein product [Homo sapiens]
GI:15088795 EMBL CAI72114.1 555 unnamed protein product [Homo sapiens]
GI:15088795 GenBank ABL24003.1 555 Sequence 124 from patent US 7129338