Gene/Proteome Database (LMPD)

LMPD ID
LMP000792
Gene ID
74596
Species
Mus musculus (Mouse)
Gene Name
CDP-diacylglycerol synthase 1
Gene Symbol
Cds1
Synonyms
4833409J18Rik; AI314024; AW125888
Alternate Names
phosphatidate cytidylyltransferase 1; CDS 1; CDP-DG synthase 1; CDP-DAG synthase 1; CDP-diglyceride synthase 1; CDP-diglyceride pyrophosphorylase 1; CTP:phosphatidate cytidylyltransferase 1
Chromosome
5
Map Location
5 E4|5
EC Number
2.7.7.41

Proteins

phosphatidate cytidylyltransferase 1
Refseq ID NP_775546
Protein GI 33186923
UniProt ID P98191
mRNA ID NM_173370
Length 461
RefSeq Status PROVISIONAL
MLELRHRGGCPGPGGAGAPPPREGEAAGGDHETESTSDKETDIDDRYGDLDARGDSDVPEVPPSSDRTPEILKKALSGLSSRWKNWWIRGILTLTMISLFFLIIYMGSFMLMLLVLGIQVKCFHEIITIGYRVYHSYDLPWFRTLSWYFLLCVNYFFYGETVADYFATFVQREEQLQFLIRYHRFISFALYLAGFCMFVLSLVKKHYRLQFYMFAWTHVTLLITVTQSHLVIQNLFEGMIWFLVPISSVICNDITAYLFGFFFGRTPLIKLSPKKTWEGFIGGFFSTVIFGFIAAYVLSKYQYFVCPVEYRSDVNSFVTECEPSELFQLQNYSLPPFLQAVLSRETVSLYPFQIHSIALSTFASLIGPFGGFFASGFKRAFKIKDFANTIPGHGGIMDRFDCQYLMATFVHVYITSFIRGPNPSKVLQQLLVLQPEQQLNIYRTLKIHLTEKGILQPTLKV

Gene Information

Entrez Gene ID
74596
Gene Name
CDP-diacylglycerol synthase 1
Gene Symbol
Cds1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IDA:MGI C endoplasmic reticulum
GO:0005789 IEA:Ensembl C endoplasmic reticulum membrane
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0004605 ISS:UniProtKB F phosphatidate cytidylyltransferase activity
GO:0016024 ISS:UniProtKB P CDP-diacylglycerol biosynthetic process
GO:0006661 ISS:UniProtKB P phosphatidylinositol biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu00564 Glycerophospholipid metabolism
mmu01100 Metabolic pathways
mmu04070 Phosphatidylinositol signaling system

Domain Information

InterPro Annotations

Accession Description
IPR000374 Phosphatidate cytidylyltransferase
IPR016720 Phosphatidate cytidylyltransferase, eukaryota

UniProt Annotations

Entry Information

Gene Name
CDP-diacylglycerol synthase 1
Protein Entry
CDS1_MOUSE
UniProt ID
P98191
Species
Mouse

Comments

Comment Type Description
Catalytic Activity CTP + phosphatidate = diphosphate + CDP- diacylglycerol.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
Developmental Stage Expressed in a structure probably corresponding to the thymic rudiment at embryonic day 12.5 of gestation (E12.5). No expression could be detected at earlier and later stages of embryonic development (E10.5 and E17.5).
Function Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol (PtdIns), phosphatidylglycerol, and cardiolipin. Overexpression may amplify cellular signaling responses from cytokines. May also play an important role in the signal transduction mechanism of retina and neural cells (By similarity). {ECO:0000250}.
Pathway Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
Similarity Belongs to the CDS family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Cytoplasmic aspect of the endoplasmic reticulum. {ECO:0000250}.
Subunit Interacts with FOS; this interaction may enhance catalytic activity. {ECO:0000269|PubMed:22105363}.
Tissue Specificity Highly expressed in the inner segment of the photoreceptor layer of adult retina. {ECO:0000269|PubMed:9889000}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000792 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
33186923 RefSeq NP_775546 461 phosphatidate cytidylyltransferase 1

Identical Sequences to LMP000792 proteins

Reference Database Accession Length Protein Name
GI:33186923 EMBL CBV17134.1 461 unnamed protein product [Mus musculus]
GI:33186923 EMBL CBU87920.1 461 unnamed protein product [Mus musculus]
GI:33186923 EMBL CBU94032.1 461 unnamed protein product [Mus musculus]
GI:33186923 GenBank AGX54856.1 461 Sequence 10070 from patent US 8541208
GI:33186923 GenBank AGX61330.1 461 Sequence 22842 from patent US 8541208
GI:33186923 GenBank AGX94991.1 461 Sequence 70245 from patent US 8541208

Related Sequences to LMP000792 proteins

Reference Database Accession Length Protein Name
GI:33186923 DBBJ BAA28787.1 461 CDP-diacylglycerol synthase [Rattus norvegicus]
GI:33186923 GenBank AAI27493.1 461 CDP-diacylglycerol synthase 1 [Rattus norvegicus]
GI:33186923 GenBank EDL99537.1 461 CDP-diacylglycerol synthase 1 [Rattus norvegicus]
GI:33186923 RefSeq NP_112521.2 461 phosphatidate cytidylyltransferase 1 [Rattus norvegicus]
GI:33186923 RefSeq XP_006975467.1 461 PREDICTED: phosphatidate cytidylyltransferase 1 [Peromyscus maniculatus bairdii]
GI:33186923 SwissProt O35052.2 461 RecName: Full=Phosphatidate cytidylyltransferase 1; AltName: Full=CDP-DAG synthase 1; AltName: Full=CDP-DG synthase 1; AltName: Full=CDP-diacylglycerol synthase 1; Short=CDS 1; AltName: Full=CDP-diglyceride pyrophosphorylase 1; AltName: Full=CDP-diglyceride synthase 1; AltName: Full=CTP:phosphatidate cytidylyltransferase 1 [Rattus norvegicus]