Gene/Proteome Database (LMPD)

LMPD ID
LMP000793
Gene ID
26971
Species
Mus musculus (Mouse)
Gene Name
phospholipase A2, group IIF
Gene Symbol
Pla2g2f
Synonyms
-
Alternate Names
group IIF secretory phospholipase A2; sPLA2-IIF; GIIF sPLA2; mGIIFsPLA2s; phosphatidylcholine 2-acylhydrolase 2F
Chromosome
4
Map Location
4 D3|4
EC Number
3.1.1.4

Proteins

group IIF secretory phospholipase A2
Refseq ID NP_036175
Protein GI 38454186
UniProt ID Q9QZT4
mRNA ID NM_012045
Length 210
RefSeq Status VALIDATED
MADGAQANPKGFRKKALVKHSTGRKSPSLRASPSKTSRSSLGMKKFFAIAVLAGSVVTTAHSSLLNLKSMVEAITHRNSILSFVGYGCYCGLGGRGHPMDEVDWCCHAHDCCYEKLFEQGCRPYVDHYDHRIENGTMIVCTELNETECDKQTCECDKSLTLCLKDHPYRNKYRGYFNVYCQGPTPNCSIYDPYPEEVTCGHGLPATPVST

Gene Information

Entrez Gene ID
26971
Gene Name
phospholipase A2, group IIF
Gene Symbol
Pla2g2f
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005576 IEA:UniProtKB-KW C extracellular region
GO:0005509 IEA:InterPro F calcium ion binding
GO:0004623 IEA:UniProtKB-EC F phospholipase A2 activity
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process
GO:0006644 IEA:InterPro P phospholipid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu04975 Fat digestion and absorption
mmu04972 Pancreatic secretion
mmu04014 Ras signaling pathway
mmu04270 Vascular smooth muscle contraction

Domain Information

InterPro Annotations

Accession Description
IPR001211 Phospholipase A2
IPR013090 Phospholipase A2, active site
IPR016090 Phospholipase A2 domain

UniProt Annotations

Entry Information

Gene Name
phospholipase A2, group IIF
Protein Entry
PA2GF_MOUSE
UniProt ID
Q9QZT4
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9QZT4-1; Sequence=Displayed; Name=2; IsoId=Q9QZT4-2; Sequence=VSP_037525;
Biophysicochemical Properties pH dependence: Optimum pH is 6.0-7.0. {ECO:0000269|PubMed:10531313};
Catalytic Activity Phosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate. {ECO:0000255|PROSITE- ProRule:PRU10035}.
Cofactor Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 1 Ca(2+) ion per subunit.;
Developmental Stage Strongly expressed during embryogenesis. {ECO:0000269|PubMed:10531313}.
Function PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Hydrolyzes phosphatidylglycerol with a stronger preference as compared to phosphatidylcholine. {ECO:0000269|PubMed:10531313}.
Similarity Belongs to the phospholipase A2 family. {ECO:0000305}.
Subcellular Location Secreted.
Tissue Specificity Strongly expressed in testis. {ECO:0000269|PubMed:10531313}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000793 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
38454186 RefSeq NP_036175 210 group IIF secretory phospholipase A2

Identical Sequences to LMP000793 proteins

Reference Database Accession Length Protein Name
GI:38454186 DBBJ BAC26357.1 210 unnamed protein product [Mus musculus]
GI:38454186 GenBank AAI25568.1 210 Phospholipase A2, group IIF [Mus musculus]

Related Sequences to LMP000793 proteins

Reference Database Accession Length Protein Name
GI:38454186 GenBank EDL80886.1 210 rCG30768 [Rattus norvegicus]
GI:38454186 RefSeq NP_001103057.1 210 group IIF secretory phospholipase A2 [Rattus norvegicus]
GI:38454186 RefSeq XP_003506947.1 211 PREDICTED: group IIF secretory phospholipase A2 [Cricetulus griseus]
GI:38454186 RefSeq XP_005081100.1 210 PREDICTED: group IIF secretory phospholipase A2 [Mesocricetus auratus]
GI:38454186 RefSeq XP_006980959.1 211 PREDICTED: group IIF secretory phospholipase A2 [Peromyscus maniculatus bairdii]
GI:38454186 RefSeq XP_008762511.1 283 PREDICTED: group IIF secretory phospholipase A2 isoform X1 [Rattus norvegicus]