Gene/Proteome Database (LMPD)

LMPD ID
LMP000794
Gene ID
14712
Species
Mus musculus (Mouse)
Gene Name
glyceronephosphate O-acyltransferase
Gene Symbol
Gnpat
Synonyms
AU019525; D1Ertd819e; DHAPAT
Alternate Names
dihydroxyacetone phosphate acyltransferase; DAP-AT; DHAP-AT; glycerone-phosphate O-acyltransferase; acyl-CoA:dihydroxyacetonephosphateacyltransferase
Chromosome
8
Map Location
8 E2|8 72.81 cM
EC Number
2.3.1.42

Proteins

dihydroxyacetone phosphate acyltransferase
Refseq ID NP_034452
Protein GI 160298207
UniProt ID P98192
mRNA ID NM_010322
Length 678
RefSeq Status VALIDATED
MDVPSSSSSRFSVGSASPSSVLLYAKDLKKWDEFEDLLEERRHISDFKFAMKCYTPPLYRGITPCKPGDIKSIVLSSEEINYVIKQLSRESLTGVDVLREEASEILEEMSHKLRIGAIRFFAFVLSKIFKQIFSKVCVNEEGIQKLQRAVQEHPVVLLPSHRSYIDFLMLSFILYSYDLPVPVIAAGMDFLGMRVVSELLRMSGAFFMRRTFGGNKLYWAVFSEYVKTMLRCGYAPVEFFLEGTRSRAAKTLTPKFGLLNIVMEPFFKREVFDTYFVPISISYDKILEESLYAYEILGVPKPKESTTGLLKARRILSENFGSIHVYFGDPVSLRSLAAGRLNRNTYNLVPRCIPQKQPEDVQAFVTEVAYKMQLLQIENLALSPWLLVVTILLQNQLSMDFDALVEKTLWLKGVTQVFGGFLLWPDNKLPEEVVQSSILLHSNLASLVKDQVVLKMNSGSSQVVNGLVPEHIALLMCSAYRNQLLNIFARPSLVALALHMTPGLRKEDVFSCFSFLRNVFSDEFIFLPGNTLRDFEEGCYLLCKAEAMQMAGKDIILTDKGTAVLQFLTSLFKPFVESYQLLCRYLLHEEDYFGEKEYLVAARKFTRQLLDQGSSQCYDALSSELQKNALAAFVRLGVVEKKKVDSKYVYYVNGPATSKLEEMLGCKKPIGKPATAKL

Gene Information

Entrez Gene ID
14712
Gene Name
glyceronephosphate O-acyltransferase
Gene Symbol
Gnpat
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005739 IEA:Ensembl C mitochondrion
GO:0005782 TAS:MGI C peroxisomal matrix
GO:0005778 IEA:Ensembl C peroxisomal membrane
GO:0003824 IDA:MGI F catalytic activity
GO:0016287 IDA:MGI F glycerone-phosphate O-acyltransferase activity
GO:0016290 IEA:Ensembl F palmitoyl-CoA hydrolase activity
GO:0021587 IMP:MGI P cerebellum morphogenesis
GO:0008611 IMP:MGI P ether lipid biosynthetic process
GO:0006650 IEA:UniProtKB-UniPathway P glycerophospholipid metabolic process
GO:0061024 IMP:MGI P membrane organization
GO:0042552 IMP:MGI P myelination
GO:0030913 IMP:MGI P paranodal junction assembly
GO:0042493 IEA:Ensembl P response to drug
GO:0070542 IEA:Ensembl P response to fatty acid
GO:0007584 IEA:Ensembl P response to nutrient
GO:0042594 IEA:Ensembl P response to starvation
GO:0007416 IMP:MGI P synapse assembly

KEGG Pathway Links

KEGG Pathway ID Description
mmu00564 Glycerophospholipid metabolism
mmu04146 Peroxisome

REACTOME Pathway Links

REACTOME Pathway ID Description
5892979 Plasmalogen biosynthesis
5892982 Synthesis of PA

Domain Information

InterPro Annotations

Accession Description
IPR028353 Dihydroxyacetone phosphate acyltransferase
IPR022284 Glycerol-3-phosphate O-acyltransferase/Dihydroxyacetone phosphate acyltransferase
IPR002123 Phospholipid/glycerol acyltransferase

UniProt Annotations

Entry Information

Gene Name
glyceronephosphate O-acyltransferase
Protein Entry
GNPAT_MOUSE
UniProt ID
P98192
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Acyl-CoA + glycerone phosphate = CoA + acylglycerone phosphate.
Domain The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. {ECO:0000250}.
Pathway Membrane lipid metabolism; glycerophospholipid metabolism.
Similarity Belongs to the GPAT/DAPAT family. {ECO:0000305}.
Subcellular Location Peroxisome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Matrix side {ECO:0000250}. Note=Exclusively localized to the lumenal side of the peroxisomal membrane. {ECO:0000250}.
Subunit May be part of a heterotrimeric complex composed of DAP- AT, ADAP-S and a modified form of DAP-AT.
Tissue Specificity Highly expressed in liver and testis. Lower levels in heart, brain, lung and kidney. Detected in spleen.

Identical and Related Proteins

Unique RefSeq proteins for LMP000794 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
160298207 RefSeq NP_034452 678 dihydroxyacetone phosphate acyltransferase

Identical Sequences to LMP000794 proteins

Reference Database Accession Length Protein Name
GI:160298207 DBBJ BAB23424.1 678 unnamed protein product [Mus musculus]
GI:160298207 DBBJ BAB23550.1 678 unnamed protein product [Mus musculus]
GI:160298207 DBBJ BAB27251.1 678 unnamed protein product [Mus musculus]
GI:160298207 GenBank AAD55351.1 678 peroxisomal acyl-CoA:dihydroxyacetone phosphate acyltransferase [Mus musculus]
GI:160298207 GenBank EDL11784.1 678 glyceronephosphate O-acyltransferase, isoform CRA_a [Mus musculus]
GI:160298207 SwissProt P98192.1 678 RecName: Full=Dihydroxyacetone phosphate acyltransferase; Short=DAP-AT; Short=DHAP-AT; AltName: Full=Acyl-CoA:dihydroxyacetonephosphateacyltransferase; AltName: Full=Glycerone-phosphate O-acyltransferase [Mus musculus]

Related Sequences to LMP000794 proteins

Reference Database Accession Length Protein Name
GI:160298207 DBBJ BAE29873.1 678 unnamed protein product [Mus musculus]
GI:160298207 DBBJ BAE39176.1 678 unnamed protein product [Mus musculus]
GI:160298207 GenBank AAG17548.1 678 acyl-CoA:dihydroxyacetonephosphate acyltransferase [Rattus norvegicus]
GI:160298207 GenBank AAH25972.1 678 Glyceronephosphate O-acyltransferase [Mus musculus]
GI:160298207 GenBank EDL96743.1 678 glyceronephosphate O-acyltransferase, isoform CRA_a [Rattus norvegicus]
GI:160298207 SwissProt Q9ES71.1 678 RecName: Full=Dihydroxyacetone phosphate acyltransferase; Short=DAP-AT; Short=DHAP-AT; AltName: Full=Acyl-CoA:dihydroxyacetonephosphateacyltransferase; AltName: Full=Glycerone-phosphate O-acyltransferase [Rattus norvegicus]