Gene/Proteome Database (LMPD)

LMPD ID
LMP000805
Gene ID
21391
Species
Mus musculus (Mouse)
Gene Name
thromboxane A synthase 1, platelet
Gene Symbol
Tbxas1
Synonyms
CYP5; CYP5A1; THAS; TS; TXAS; TXS
Alternate Names
thromboxane-A synthase; TXA synthase; cytochrome P450 5A1
Chromosome
6
Map Location
6 F1-pter|6 17.85 cM
EC Number
5.3.99.5

Proteins

thromboxane-A synthase
Refseq ID NP_035669
Protein GI 79750133
UniProt ID P36423
mRNA ID NM_011539
Length 533
RefSeq Status VALIDATED
MEVLGLLKFEVSGTIVTVTLLVALLALLKWYSMSAFSRLEKLGIRHPKPSPFVGNLMFFRQGFWESQLELRERYGPLCGYYLGRRMHVVISEPDMIKQVLVENFSNFSNRMASGLEPKMVADSVLLLRDRRWEEVRGALMSSFSPEKLDEMTPLISQACELLVAHLKRYAASRDAFNIQRCYCCYTIDVVASVAFGTQVDSQNSPEDPFVQHCRRASTFCIPRPLLVLILSFPSIMVPLARILPNKNRDELNGFFNTLIRNVIALRDQQAAEERRRDFLQMVLDAQHSMNSVGVEGFDMVPESLSSSECTKEPPQRCHPTSTSKPFTVDEIVGQAFLFLIAGHEVITNTLSFITYLLATHPDCQERLLKEVDLFMGKHPAPEYHSLQEGLPYLDMVISETLRMYPPAFRFTREAAQDCEVLGQRIPAGTVLEIAVGALHHDPEHWPNPETFDPERFTAEARLQRRPFTYLPFGAGPRSCLGVRLGLLVVKLTILQVLHKFRFEASPETQVPLQLESKSALGPKNGVYIKIVSR

Gene Information

Entrez Gene ID
21391
Gene Name
thromboxane A synthase 1, platelet
Gene Symbol
Tbxas1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0020037 IEA:InterPro F heme binding
GO:0005506 IEA:InterPro F iron ion binding
GO:0004497 IEA:UniProtKB-KW F monooxygenase activity
GO:0016705 IEA:InterPro F oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0004796 IMP:MGI F thromboxane-A synthase activity
GO:0030644 IEA:Ensembl P cellular chloride ion homeostasis
GO:0045907 IEA:Ensembl P positive regulation of vasoconstriction
GO:0001516 IEA:UniProtKB-KW P prostaglandin biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu04611 Platelet activation

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY3DJ-35583 biosynthesis of prostaglandins

Domain Information

InterPro Annotations

Accession Description
IPR001128 Cytochrome P450
IPR017972 Cytochrome P450, conserved site
IPR002401 Cytochrome P450, E-class, group I

UniProt Annotations

Entry Information

Gene Name
thromboxane A synthase 1, platelet
Protein Entry
THAS_MOUSE
UniProt ID
P36423
Species
Mouse

Comments

Comment Type Description
Catalytic Activity (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15- hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-9-alpha,11-alpha- epoxy-15-hydroxythromboxa-5,13-dienoate.
Cofactor Name=heme; Xref=ChEBI:CHEBI:30413;
Similarity Belongs to the cytochrome P450 family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Subunit Monomer. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000805 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
79750133 RefSeq NP_035669 533 thromboxane-A synthase

Identical Sequences to LMP000805 proteins

Reference Database Accession Length Protein Name
GI:79750133 GenBank AAB39850.1 533 thromboxane synthase [Mus musculus]
GI:79750133 GenBank EDL13618.1 533 thromboxane A synthase 1, platelet [Mus musculus]
GI:79750133 RefSeq XP_006505936.1 533 PREDICTED: thromboxane-A synthase isoform X1 [Mus musculus]
GI:79750133 RefSeq XP_006505937.1 533 PREDICTED: thromboxane-A synthase isoform X2 [Mus musculus]
GI:79750133 RefSeq XP_006505938.1 533 PREDICTED: thromboxane-A synthase isoform X3 [Mus musculus]
GI:79750133 SwissProt P36423.2 533 RecName: Full=Thromboxane-A synthase; Short=TS; Short=TXA synthase; Short=TXS; AltName: Full=Cytochrome P450 5A1 [Mus musculus]

Related Sequences to LMP000805 proteins

Reference Database Accession Length Protein Name
GI:79750133 GenBank AAB87704.1 533 thromboxane synthase [Mus musculus]
GI:79750133 GenBank AAH29014.1 533 Thromboxane A synthase 1, platelet [Mus musculus]
GI:79750133 GenBank EDM15371.1 533 thromboxane A synthase 1 [Rattus norvegicus]
GI:79750133 GenBank AED45727.1 543 Sequence 2001 from patent US 7892730
GI:79750133 RefSeq XP_006505939.1 533 PREDICTED: thromboxane-A synthase isoform X4 [Mus musculus]
GI:79750133 RefSeq XP_006505940.1 494 PREDICTED: thromboxane-A synthase isoform X5 [Mus musculus]