Gene/Proteome Database (LMPD)

LMPD ID
LMP000810
Gene ID
5728
Species
Homo sapiens (Human)
Gene Name
phosphatase and tensin homolog
Gene Symbol
PTEN
Synonyms
10q23del; BZS; CWS1; DEC; GLM2; MHAM; MMAC1; PTEN1; TEP1
Chromosome
10
Map Location
10q23.3
Summary
This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for PTEN

Proteins

phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Refseq ID NP_000305
Protein GI 73765544
UniProt ID P60484
mRNA ID NM_000314
Length 403
RefSeq Status REVIEWED
MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVCQLKVKIYSSNSGPTRREDKFMYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFIPGPEETSEKVENGSLCDQEIDSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEEPSNPEASSSTSVTPDVSDNEPDHYRYSDTTDSDPENEPFDEDQHTQITKV

Gene Information

Entrez Gene ID
5728
Gene Name
phosphatase and tensin homolog
Gene Symbol
PTEN
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:HPA C cytoplasm
GO:0043197 IEA:Ensembl C dendritic spine
GO:0005739 IEA:Ensembl C mitochondrion
GO:0035749 IEA:Ensembl C myelin sheath adaxonal region
GO:0005634 IDA:HPA C nucleus
GO:0045211 IEA:Ensembl C postsynaptic membrane
GO:0043220 IEA:Ensembl C Schmidt-Lanterman incisure
GO:0000287 IEA:InterPro F magnesium ion binding
GO:0016314 IEA:InterPro F phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
GO:0051800 IEA:InterPro F phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
GO:0004725 IEA:InterPro F protein tyrosine phosphatase activity
GO:0008138 IEA:InterPro F protein tyrosine/serine/threonine phosphatase activity
GO:0007092 IEA:Ensembl P activation of mitotic anaphase-promoting complex activity
GO:0007568 IEA:Ensembl P aging
GO:0001525 IEA:Ensembl P angiogenesis
GO:0048738 IEA:Ensembl P cardiac muscle tissue development
GO:0032286 IEA:Ensembl P central nervous system myelin maintenance
GO:0021955 IEA:Ensembl P central nervous system neuron axonogenesis
GO:0060997 IEA:Ensembl P dendritic spine morphogenesis
GO:0021542 IEA:Ensembl P dentate gyrus development
GO:0043542 IEA:Ensembl P endothelial cell migration
GO:0048853 IEA:Ensembl P forebrain morphogenesis
GO:0046855 IEA:InterPro P inositol phosphate dephosphorylation
GO:0045475 IEA:Ensembl P locomotor rhythm
GO:0060292 IEA:Ensembl P long term synaptic depression
GO:0060291 IEA:Ensembl P long-term synaptic potentiation
GO:0060179 IEA:Ensembl P male mating behavior
GO:0042711 IEA:Ensembl P maternal behavior
GO:0007613 IEA:Ensembl P memory
GO:0033555 IEA:Ensembl P multicellular organismal response to stress
GO:0043066 IEA:Ensembl P negative regulation of apoptotic process
GO:0050771 IEA:Ensembl P negative regulation of axonogenesis
GO:0090344 IEA:Ensembl P negative regulation of cell aging
GO:0030336 IEA:InterPro P negative regulation of cell migration
GO:0045792 IEA:Ensembl P negative regulation of cell size
GO:0061002 IEA:Ensembl P negative regulation of dendritic spine morphogenesis
GO:0050680 IEA:Ensembl P negative regulation of epithelial cell proliferation
GO:0090394 IEA:Ensembl P negative regulation of excitatory postsynaptic membrane potential
GO:0051895 IEA:InterPro P negative regulation of focal adhesion assembly
GO:0031642 IEA:Ensembl P negative regulation of myelination
GO:0046621 IEA:Ensembl P negative regulation of organ growth
GO:0050765 IEA:Ensembl P negative regulation of phagocytosis
GO:0051898 IEA:Ensembl P negative regulation of protein kinase B signaling
GO:0090071 IEA:Ensembl P negative regulation of ribosome biogenesis
GO:2000808 IEA:Ensembl P negative regulation of synaptic vesicle clustering
GO:0007270 IEA:Ensembl P neuron-neuron synaptic transmission
GO:0046856 IEA:InterPro P phosphatidylinositol dephosphorylation
GO:0048008 IEA:Ensembl P platelet-derived growth factor receptor signaling pathway
GO:0043065 IEA:Ensembl P positive regulation of apoptotic process
GO:2001235 IEA:Ensembl P positive regulation of apoptotic signaling pathway
GO:0008284 IEA:Ensembl P positive regulation of cell proliferation
GO:2000463 IEA:Ensembl P positive regulation of excitatory postsynaptic membrane potential
GO:0097107 IEA:Ensembl P postsynaptic density assembly
GO:0060134 IEA:Ensembl P prepulse inhibition
GO:0097105 IEA:Ensembl P presynaptic membrane assembly
GO:0060736 IEA:Ensembl P prostate gland growth
GO:0043491 IEA:Ensembl P protein kinase B signaling
GO:0002902 IEA:Ensembl P regulation of B cell apoptotic process
GO:0033032 IEA:Ensembl P regulation of myeloid cell apoptotic process
GO:0031647 IEA:InterPro P regulation of protein stability
GO:0046685 IEA:Ensembl P response to arsenic-containing substance
GO:0033198 IEA:Ensembl P response to ATP
GO:0042493 IEA:Ensembl P response to drug
GO:0032355 IEA:Ensembl P response to estradiol
GO:0045471 IEA:Ensembl P response to ethanol
GO:0009749 IEA:Ensembl P response to glucose
GO:0007584 IEA:Ensembl P response to nutrient
GO:0010043 IEA:Ensembl P response to zinc ion
GO:0060024 IEA:Ensembl P rhythmic synaptic transmission
GO:0035176 IEA:Ensembl P social behavior
GO:0060074 IEA:Ensembl P synapse maturation

KEGG Pathway Links

KEGG Pathway ID Description
hsa04068 FoxO signaling pathway
hsa05161 Hepatitis B
hsa05206 MicroRNAs in cancer
hsa04151 PI3K-Akt signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR017361 Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN
IPR000008 C2 domain
IPR000340 Dual specificity phosphatase, catalytic domain
IPR016130 Protein-tyrosine phosphatase, active site
IPR029021 Protein-tyrosine phosphatase-like
IPR014020 Tensin phosphatase, C2 domain
IPR029023 Tensin phosphatase, lipid phosphatase domain

UniProt Annotations

Entry Information

Gene Name
phosphatase and tensin homolog
Protein Entry
PTEN_HUMAN
UniProt ID
P60484
Species
Human

Identical and Related Proteins

Unique RefSeq proteins for LMP000810 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
73765544 RefSeq NP_000305 403 phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

Identical Sequences to LMP000810 proteins

Reference Database Accession Length Protein Name
GI:73765544 RefSeq XP_008069943.1 403 PREDICTED: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [Tarsius syrichta]
GI:73765544 RefSeq XP_008268355.1 403 PREDICTED: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [Oryctolagus cuniculus]
GI:73765544 RefSeq XP_008534287.1 403 PREDICTED: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X2 [Equus przewalskii]
GI:73765544 RefSeq XP_008574034.1 403 PREDICTED: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [Galeopterus variegatus]
GI:73765544 RefSeq XP_008687806.1 403 PREDICTED: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [Ursus maritimus]
GI:73765544 RefSeq XP_010377926.1 403 PREDICTED: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [Rhinopithecus roxellana]

Related Sequences to LMP000810 proteins

Reference Database Accession Length Protein Name
GI:73765544 GenBank AAN99401.1 597 Sequence 8 from patent US 6482795
GI:73765544 GenBank ABL22611.1 597 Sequence 8 from patent US 7129040
GI:73765544 GenBank ABT04301.1 597 Sequence 8 from patent US 7217795
GI:73765544 GenBank ADM06301.1 597 Sequence 8 from patent US 7732576
GI:73765544 RefSeq NP_001288689.1 577 phosphatase and tensin homolog [Pan paniscus]
GI:73765544 Third Party Genbank DAA64596.1 577 TPA_exp: mitochondrial PTENalpha [Pan paniscus]