Gene/Proteome Database (LMPD)
LMPD ID
LMP000829
Gene ID
Species
Homo sapiens (Human)
Gene Name
apolipoprotein F
Gene Symbol
Synonyms
Apo-F; LTIP
Alternate Names
apolipoprotein F; lipid transfer inhibitor protein
Chromosome
12
Map Location
12q13.3
Summary
The product of this gene is one of the minor apolipoproteins found in plasma. This protein forms complexes with lipoproteins and may be involved in transport and/or esterification of cholesterol. [provided by RefSeq, Jul 2008]
Orthologs
Proteins
| apolipoprotein F precursor | |
|---|---|
| Refseq ID | NP_001629 |
| Protein GI | 4502165 |
| UniProt ID | Q13790 |
| mRNA ID | NM_001638 |
| Length | 326 |
| RefSeq Status | REVIEWED |
| MTGLCGYSAPDMRGLRLIMIPVELLLCYLLLHPVDATSYGKQTNVLMHFPLSLESQTPSSDPLSCQFLHPKSLPGFSHMAPLPKFLVSLALRNALEEAGCQADVWALQLQLYRQGGVNATQVLIQHLRGLQKGRSTERNVSVEALASALQLLAREQQSTGRVGRSLPTEDCENEKEQAVHNVVQLLPGVGTFYNLGTALYYATQNCLGKARERGRDGAIDLGYDLLMTMAGMSGGPMGLAISAALKPALRSGVQQLIQYYQDQKDANISQPETTKEGLRAISDVSDLEETTTLASFISEVVSSAPYWGWAIIKSYDLDPGAGSLEI | |
| sig_peptide: 1..36 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 3989 peptide sequence: MTGLCGYSAPDMRGLRLIMIPVELLLCYLLLHPVDA mat_peptide: 165..326 product: apolipoprotein F calculated_mol_wt: 17425 peptide sequence: SLPTEDCENEKEQAVHNVVQLLPGVGTFYNLGTALYYATQNCLGKARERGRDGAIDLGYDLLMTMAGMSGGPMGLAISAALKPALRSGVQQLIQYYQDQKDANISQPETTKEGLRAISDVSDLEETTTLASFISEVVSSAPYWGWAIIKSYDLDPGAGSLEI | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005576 | NAS:UniProtKB | C | extracellular region |
| GO:0034364 | IEA:UniProtKB-KW | C | high-density lipoprotein particle |
| GO:0034362 | IEA:UniProtKB-KW | C | low-density lipoprotein particle |
| GO:0015485 | TAS:ProtInc | F | cholesterol binding |
| GO:0005319 | TAS:ProtInc | F | lipid transporter activity |
| GO:0005102 | TAS:ProtInc | F | receptor binding |
| GO:0033344 | IEA:Ensembl | P | cholesterol efflux |
| GO:0008203 | TAS:ProtInc | P | cholesterol metabolic process |
| GO:0006629 | TAS:ProtInc | P | lipid metabolic process |
| GO:0006869 | TAS:ProtInc | P | lipid transport |
| GO:0006641 | IEA:Ensembl | P | triglyceride metabolic process |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_6934 | LDL-mediated lipid transport |
| REACT_602 | Lipid digestion, mobilization, and transport |
| REACT_6823 | Lipoprotein metabolism |
| REACT_111217 | Metabolism |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR026114 | Apolipoprotein F |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Caution | It is uncertain whether Met-1 or Met-12 is the initiator. |
| Function | Minor apolipoprotein that associates with LDL. Inhibits cholesteryl ester transfer protein (CETP) activity and appears to be an important regulator of cholesterol transport. Also associates to a lesser degree with VLDL, Apo-AI and Apo-AII. |
| Ptm | O-glycosylated with core 1 or possibly core 8 glycans. |
| Subcellular Location | Secreted. |
| Tissue Specificity | Expressed by the liver and secreted in plasma. |
Identical and Related Proteins
Unique RefSeq proteins for LMP000829 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 4502165 | RefSeq | NP_001629 | 326 | apolipoprotein F precursor |
Identical Sequences to LMP000829 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:4502165 | GenBank | AAH26257.1 | 326 | Apolipoprotein F [Homo sapiens] |
| GI:4502165 | GenBank | EAW96938.1 | 326 | apolipoprotein F [Homo sapiens] |
| GI:4502165 | GenBank | ADQ32134.1 | 326 | apolipoprotein F, partial [synthetic construct] |
| GI:4502165 | GenBank | AHE01111.1 | 326 | Sequence 56027 from patent US 8586006 |
| GI:4502165 | GenBank | AIC48272.1 | 326 | APOF, partial [synthetic construct] |
| GI:4502165 | SwissProt | Q13790.2 | 326 | RecName: Full=Apolipoprotein F; Short=Apo-F; AltName: Full=Lipid transfer inhibitor protein; Short=LTIP; Flags: Precursor [Homo sapiens] |
Related Sequences to LMP000829 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:4502165 | DBBJ | BAG37406.1 | 326 | unnamed protein product [Homo sapiens] |
| GI:4502165 | RefSeq | XP_522601.2 | 326 | PREDICTED: apolipoprotein F [Pan troglodytes] |
| GI:4502165 | RefSeq | XP_004053425.1 | 349 | PREDICTED: apolipoprotein F [Gorilla gorilla gorilla] |
| GI:4502165 | RefSeq | XP_008001853.1 | 326 | PREDICTED: apolipoprotein F [Chlorocebus sabaeus] |
| GI:4502165 | RefSeq | XP_008976836.1 | 323 | PREDICTED: LOW QUALITY PROTEIN: apolipoprotein F [Pan paniscus] |
| GI:4502165 | RefSeq | XP_009246176.1 | 349 | PREDICTED: apolipoprotein F isoform X1 [Pongo abelii] |