Gene/Proteome Database (LMPD)

LMPD ID
LMP000830
Gene ID
283748
Species
Homo sapiens (Human)
Gene Name
phospholipase A2, group IVD (cytosolic)
Gene Symbol
PLA2G4D
Synonyms
cPLA2delta
Alternate Names
cytosolic phospholipase A2 delta; cPLA2-delta; phospholipase A2 group IVD; phospholipase A2 delta, cytosolic
Chromosome
15
Map Location
15q15.1
EC Number
3.1.1.4
Summary
The phospholipase A2 enzyme family, including PLA2G4D, catalyze the hydrolysis of glycerophospholipids at the sn-2 position and then liberate free fatty acids and lysophospholipids (Chiba et al., 2004 [PubMed 14709560]).[supplied by OMIM, Jun 2009]
Orthologs
View orthologs and multiple alignments for PLA2G4D

Proteins

cytosolic phospholipase A2 delta
Refseq ID NP_828848
Protein GI 116174754
UniProt ID Q86XP0
mRNA ID NM_178034
Length 818
RefSeq Status VALIDATED
MESLSPGGPPGHPYQGEASTCWQLTVRVLEARNLRWADLLSEADPYVILQLSTAPGMKFKTKTLTDTSHPVWNEAFRFLIQSQVKNVLELSIYDEDSVTEDDICFKVLYDISEVLPGKLLRKTFSQSPQGEEELDVEFLMEETSDRPENLITNKVIVARELSCLDVHLDSTGSTAVVADQDKLELELVLKGSYEDTQTSFLGTASAFRFHYMAALETELSGRLRSSRSNGWNGDNSAGYLTVPLRPLTIGKEVTMDVPAPNAPGVRLQLKAEGCPEELAVHLGFNLCAEEQAFLSRRKQVVAKALKQALQLDRDLQEDEVPVVGIMATGGGARAMTSLYGHLLALQKLGLLDCVTYFSGISGSTWTMAHLYGDPEWSQRDLEGPIRYAREHLAKSKLEVFSPERLASYRRELELRAEQGHPTTFVDLWALVLESMLHGQVMDQKLSGQRAALERGQNPLPLYLSLNVKENNLETLDFKEWVEFSPYEVGFLKYGAFVPPELFGSEFFMGRLMRRIPEPRICFLEAIWSNIFSLNLLDAWYDLTSSGESWKQHIKDKTRSLEKEPLTTSGTSSRLEASWLQPGTALAQAFKGFLTGRPLHQRSPNFLQGLQLHQDYCSHKDFSTWADYQLDSMPSQLTPKEPRLCLVDAAYFINTSSPSMFRPGRRLDLILSFDYSLSAPFEALQQTELYCRARGLPFPRVEPSPQDQHQPRECHLFSDPACPEAPILLHFPLVNASFKDHSAPGVQRSPAELQGGQVDLTGATCPYTLSNMTYKEEDFERLLRLSDYNVQTSQGAILQALRTALKHRTLEARPPRAQT

Gene Information

Entrez Gene ID
283748
Gene Name
phospholipase A2, group IVD (cytosolic)
Gene Symbol
PLA2G4D
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0031410 IEA:UniProtKB-KW C cytoplasmic vesicle
GO:0005829 TAS:Reactome C cytosol
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0004623 IEA:UniProtKB-EC F phospholipase A2 activity
GO:0046474 TAS:Reactome P glycerophospholipid biosynthetic process
GO:0006654 TAS:Reactome P phosphatidic acid biosynthetic process
GO:0036151 TAS:Reactome P phosphatidylcholine acyl-chain remodeling
GO:0036152 TAS:Reactome P phosphatidylethanolamine acyl-chain remodeling
GO:0036148 TAS:Reactome P phosphatidylglycerol acyl-chain remodeling
GO:0036149 TAS:Reactome P phosphatidylinositol acyl-chain remodeling
GO:0036150 TAS:Reactome P phosphatidylserine acyl-chain remodeling
GO:0009395 IEA:InterPro P phospholipid catabolic process
GO:0006644 TAS:Reactome P phospholipid metabolic process
GO:0044281 TAS:Reactome P small molecule metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa04750 Inflammatory mediator regulation of TRP channels
hsa04921 Oxytocin signaling pathway
hsa04611 Platelet activation
hsa04014 Ras signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase
IPR000008 C2 domain
IPR002642 Lysophospholipase, catalytic domain

UniProt Annotations

Entry Information

Gene Name
phospholipase A2, group IVD (cytosolic)
Protein Entry
PA24D_HUMAN
UniProt ID
Q86XP0
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q86XP0-1; Sequence=Displayed; Name=2; IsoId=Q86XP0-2; Sequence=VSP_019881, VSP_019882; Note=May be due to an intron retention. Ref.2 (AAH34571) sequence is in conflict in position: 713:G->R. ;
Catalytic Activity Phosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate.
Domain The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+) (By similarity).
Enzyme Regulation Stimulated by cytosolic Ca(2+).
Function Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Not arachidonic acid-specific but has linoleic acid-specific activity. May play a role in inflammation in psoriatic lesions.
Sequence Caution Sequence=AAH34571.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ;
Similarity Contains 1 C2 domain. {ECO
Similarity Contains 1 PLA2c domain. {ECO
Subcellular Location Cytoplasm, cytosol. Cytoplasmic vesicle membrane {ECO
Tissue Specificity Expressed in stratified squamous epithelia, such as those in skin and cervix, but not in other tissues. Strongly expressed in the upper spinous layer of the psoriatic epidermis, expressed weakly and discontinuously in atopic dermatitis and mycosis fungoides, and not detected in the epidermis of normal skin.

Identical and Related Proteins

Unique RefSeq proteins for LMP000830 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
116174754 RefSeq NP_828848 818 cytosolic phospholipase A2 delta

Identical Sequences to LMP000830 proteins

Reference Database Accession Length Protein Name
GI:116174754 DBBJ BAI45365.1 818 phospholipase A2, group IVD, partial [synthetic construct]
GI:116174754 GenBank EAW92529.1 818 phospholipase A2, group IVD (cytosolic), isoform CRA_a [Homo sapiens]
GI:116174754 GenBank AAI40417.1 818 Phospholipase A2, group IVD (cytosolic), partial [synthetic construct]
GI:116174754 GenBank AAI46534.1 818 Phospholipase A2, group IVD (cytosolic) [synthetic construct]
GI:116174754 SwissProt Q86XP0.2 818 RecName: Full=Cytosolic phospholipase A2 delta; Short=cPLA2-delta; AltName: Full=Phospholipase A2 group IVD [Homo sapiens]

Related Sequences to LMP000830 proteins

Reference Database Accession Length Protein Name
GI:116174754 DBBJ BAC67158.1 818 cytosolic phospholipase A2 delta [Homo sapiens]
GI:116174754 GenBank ADI53371.1 818 Sequence 9 from patent US 7422887
GI:116174754 GenBank AEU43285.1 818 Sequence 34 from patent US 8052970
GI:116174754 GenBank AHE02131.1 818 Sequence 59980 from patent US 8586006
GI:116174754 RefSeq XP_003266809.1 818 PREDICTED: cytosolic phospholipase A2 delta [Nomascus leucogenys]
GI:116174754 RefSeq XP_003805661.1 818 PREDICTED: cytosolic phospholipase A2 delta [Pan paniscus]