Gene/Proteome Database (LMPD)

LMPD ID
LMP000836
Gene ID
10948
Species
Homo sapiens (Human)
Gene Name
StAR-related lipid transfer (START) domain containing 3
Gene Symbol
STARD3
Synonyms
CAB1; MLN64; es64
Alternate Names
stAR-related lipid transfer protein 3; MLN 64; metastatic lymph node protein 64; START domain-containing protein 3; metastatic lymph node gene 64 protein; steroidogenic acute regulatory protein related
Chromosome
17
Map Location
17q11-q12
Summary
This gene encodes a member of a subfamily of lipid trafficking proteins that are characterized by a C-terminal steroidogenic acute regulatory domain and an N-terminal metastatic lymph node 64 domain. The encoded protein localizes to the membranes of late endosomes and may be involved in exporting cholesterol. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]
Orthologs
View orthologs and multiple alignments for STARD3

Proteins

stAR-related lipid transfer protein 3 isoform 1
Refseq ID NP_006795
Protein GI 260763902
UniProt ID Q14849
mRNA ID NM_006804
Length 445
RefSeq Status REVIEWED
MSKLPRELTRDLERSLPAVASLGSSLSHSQSLSSHLLPPPEKRRAISDVRRTFCLFVTFDLLFISLLWIIELNTNTGIRKNLEQEIIQYNFKTSFFDIFVLAFFRFSGLLLGYAVLRLRHWWVIAVTTLVSSAFLIVKVILSELLSKGAFGYLLPIVSFVLAWLETWFLDFKVLPQEAEEERWYLAAQVAVARGPLLFSGALSEGQFYSPPESFAGSDNESDEEVAGKKSFSAQEREYIRQGKEATAVVDQILAQEENWKFEKNNEYGDTVYTIEVPFHGKTFILKTFLPCPAELVYQEVILQPERMVLWNKTVTACQILQRVEDNTLISYDVSAGAAGGVVSPRDFVNVRRIERRRDRYLSSGIATSHSAKPPTHKYVRGENGPGGFIVLKSASNPRVCTFVWILNTDLKGRLPRYLIHQSLAATMFEFAFHLRQRISELGARA
stAR-related lipid transfer protein 3 isoform 2
Refseq ID NP_001159409
Protein GI 260763904
UniProt ID Q14849
mRNA ID NM_001165937
Length 445
RefSeq Status REVIEWED
MSKLPRELTRDLERSLPAVASLGSSLSHSQSLSSHLLPPPEKRRAISDVRRTFCLFVTFDLLFISLLWIIELNTNTGIRKNLEQEIIQYNFKTSFFDIFVLAFFRFSGLLLGYAVLRLRHWSRRWCPVHSSLSRSSSLSCSAKGHLATCSPSSLLSSPGWRPGSLTSKSYPRKLKRSDSAPPGYLAAQVAVARGPLLFSGALSEGQFYSPPESFAGSDNESDEEVAGKKSFSAQEREYIRQGKEATAVVDQILAQEENWKFEKNNEYGDTVYTIEVPFHGKTFILKTFLPCPAELVYQEVILQPERMVLWNKTVTACQILQRVEDNTLISYDVSAGAAGGVVSPRDFVNVRRIERRRDRYLSSGIATSHSAKPPTHKYVRGENGPGGFIVLKSASNPRVCTFVWILNTDLKGRLPRYLIHQSLAATMFEFAFHLRQRISELGARA
stAR-related lipid transfer protein 3 isoform 3
Refseq ID NP_001159410
Protein GI 260763906
UniProt ID Q14849
mRNA ID NM_001165938
Length 427
RefSeq Status REVIEWED
MSKLPRELTRDLERSLPAVASLGSSLSHSQSLSSHLLPPPEKRRAISDVRRTFCLFVTFDLLFISLLWIIELNTNTGIRKNLEQEIIQYNFKTSFFDIFVLAFFRFSGLLLGYAVLRLRHWWVIALLSKGAFGYLLPIVSFVLAWLETWFLDFKVLPQEAEEERWYLAAQVAVARGPLLFSGALSEGQFYSPPESFAGSDNESDEEVAGKKSFSAQEREYIRQGKEATAVVDQILAQEENWKFEKNNEYGDTVYTIEVPFHGKTFILKTFLPCPAELVYQEVILQPERMVLWNKTVTACQILQRVEDNTLISYDVSAGAAGGVVSPRDFVNVRRIERRRDRYLSSGIATSHSAKPPTHKYVRGENGPGGFIVLKSASNPRVCTFVWILNTDLKGRLPRYLIHQSLAATMFEFAFHLRQRISELGARA

Gene Information

Entrez Gene ID
10948
Gene Name
StAR-related lipid transfer (START) domain containing 3
Gene Symbol
STARD3
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 TAS:ProtInc C cytoplasm
GO:0005768 IEA:UniProtKB-KW C endosome
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005765 IDA:UniProtKB C lysosomal membrane
GO:0005739 IEA:Ensembl C mitochondrion
GO:0015485 IDA:MGI F cholesterol binding
GO:0008203 TAS:ProtInc P cholesterol metabolic process
GO:0006629 TAS:ProtInc P lipid metabolic process
GO:0006869 IEA:UniProtKB-KW P lipid transport
GO:0006839 TAS:ProtInc P mitochondrial transport
GO:0006701 IEA:Ensembl P progesterone biosynthetic process
GO:0008202 TAS:ProtInc P steroid metabolic process

Domain Information

InterPro Annotations

Accession Description
IPR019498 MENTAL domain
IPR023393 START-like domain
IPR002913 START_lipid-bd_dom
IPR000799 Steroidogenic acute regulatory protein-like

UniProt Annotations

Entry Information

Gene Name
StAR-related lipid transfer (START) domain containing 3
Protein Entry
STAR3_HUMAN
UniProt ID
Q14849
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q14849-1; Sequence=Displayed; Name=2; IsoId=Q14849-2; Sequence=VSP_042710; Note=No experimental confirmation available.; Name=3; IsoId=Q14849-3; Sequence=VSP_045361; Note=No experimental confirmation available.;
Function Binds and transports cholesterol. Promotes steroidogenesis in placenta and brain.
Interaction Q9P0L0:VAPA; NbExp=4; IntAct=EBI-9819369, EBI-1059156;
Similarity Contains 1 MENTAL domain. {ECO
Similarity Contains 1 START domain. {ECO
Subcellular Location Late endosome membrane; Multi-pass membrane protein.
Subunit Can form homodimers. Interacts with STARD3NL.
Web Resource Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/MLN64ID202.html";

Identical and Related Proteins

Unique RefSeq proteins for LMP000836 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
260763902 RefSeq NP_006795 445 stAR-related lipid transfer protein 3 isoform 1
260763904 RefSeq NP_001159409 445 stAR-related lipid transfer protein 3 isoform 2
260763906 RefSeq NP_001159410 427 stAR-related lipid transfer protein 3 isoform 3

Identical Sequences to LMP000836 proteins

Reference Database Accession Length Protein Name
GI:260763906 DBBJ BAG61955.1 427 unnamed protein product [Homo sapiens]
GI:260763902 GenBank ACE86541.1 445 StAR-related lipid transfer (START) domain containing 3 protein, partial [synthetic construct]
GI:260763902 GenBank JAA02920.1 445 StAR-related lipid transfer (START) domain containing 3 [Pan troglodytes]
GI:260763902 GenBank JAA18600.1 445 StAR-related lipid transfer (START) domain containing 3 [Pan troglodytes]
GI:260763902 GenBank JAA36658.1 445 StAR-related lipid transfer (START) domain containing 3 [Pan troglodytes]
GI:260763902 GenBank AIC63314.1 445 STARD3, partial [synthetic construct]
GI:260763902 RefSeq XP_006721708.1 445 PREDICTED: stAR-related lipid transfer protein 3 isoform X3 [Homo sapiens]

Related Sequences to LMP000836 proteins

Reference Database Accession Length Protein Name
GI:260763904 DBBJ BAG62493.1 445 unnamed protein product [Homo sapiens]
GI:260763902 GenBank AAE34920.1 445 Sequence 6 from patent US 5981218
GI:260763906 GenBank AAH08356.1 445 StAR-related lipid transfer (START) domain containing 3 [Homo sapiens]
GI:260763902 GenBank AAP35610.1 445 START domain containing 3 [Homo sapiens]
GI:260763906 GenBank EAW60585.1 445 START domain containing 3, isoform CRA_b [Homo sapiens]
GI:260763902 GenBank ABM84661.1 445 START domain containing 3, partial [synthetic construct]
GI:260763902 GenBank ADL88176.1 445 Sequence 296 from patent US 7705120
GI:260763902 GenBank JAA29003.1 445 StAR-related lipid transfer (START) domain containing 3 [Pan troglodytes]
GI:260763902 GenBank AIC55882.1 445 STARD3, partial [synthetic construct]
GI:260763906 GenBank AIC63314.1 445 STARD3, partial [synthetic construct]
GI:260763906 RefSeq NP_006795.3 445 stAR-related lipid transfer protein 3 isoform 1 [Homo sapiens]
GI:260763906 RefSeq XP_004041862.1 427 PREDICTED: stAR-related lipid transfer protein 3 isoform 2 [Gorilla gorilla gorilla]
GI:260763904 RefSeq XP_005321837.1 446 PREDICTED: stAR-related lipid transfer protein 3 isoform X2 [Ictidomys tridecemlineatus]
GI:260763904 RefSeq XP_006176420.1 446 PREDICTED: stAR-related lipid transfer protein 3 isoform X2 [Camelus ferus]
GI:260763904 RefSeq XP_006214308.1 446 PREDICTED: stAR-related lipid transfer protein 3 isoform X2 [Vicugna pacos]
GI:260763904 RefSeq XP_007531005.1 450 PREDICTED: stAR-related lipid transfer protein 3 isoform X1 [Erinaceus europaeus]
GI:260763904 RefSeq XP_008955060.1 445 PREDICTED: stAR-related lipid transfer protein 3 isoform X2 [Pan paniscus]
GI:260763906 SwissProt Q14849.2 445 RecName: Full=StAR-related lipid transfer protein 3; AltName: Full=Metastatic lymph node gene 64 protein; Short=MLN 64; AltName: Full=Protein CAB1; AltName: Full=START domain-containing protein 3; Short=StARD3 [Homo sapiens]