Gene/Proteome Database (LMPD)

LMPD ID
LMP000847
Gene ID
113868
Species
Mus musculus (Mouse)
Gene Name
acetyl-Coenzyme A acyltransferase 1A
Gene Symbol
Acaa1a
Synonyms
Acaa; Acaa1; D9Ertd25e; PTL
Alternate Names
3-ketoacyl-CoA thiolase A, peroxisomal; thiolase A; beta-ketothiolase A; acetyl-CoA acyltransferase A; peroxisomal 3-ketoacyl-CoA thiolase; peroxisomal 3-oxoacyl-CoA thiolase A; peroxisomal 3-oxoacyl-Coenzyme A thiolase
Chromosome
9
Map Location
9 F4|9 71.33 cM
EC Number
2.3.1.16

Proteins

3-ketoacyl-CoA thiolase A, peroxisomal precursor
Refseq ID NP_570934
Protein GI 18700004
UniProt ID Q921H8
mRNA ID NM_130864
Length 424
RefSeq Status PROVISIONAL
MHRLQVVLGHLAGRPESSSALQAAPCSARFPQASASDVVVVHGRRTPIGRASRGGFKNTTPDELLSAVLTAVLQDVRLKPEQLGDISVGNVLEPGAGAVMARIAQFLSGIPETVPLSTVNRQCSSGLQAVANIAGGIRNGSYDIGMACGVESMSLSGMGNPGNISSRLLESEKARDCLTPMGMTSENVAERFGISRQKQDDFALASQQKAASAQSRGCFRAEIVPVTTTVLDDKGDKKTITVSQDEGVRPSTTMQGLAKLKPAFKDGGSTTAGNSSQVSDGAAAVLLARRSKAEELGLPILGVLRSYAVVGVPPDVMGIGPAYAIPAALQKAGLTVNDIDIFEINEAFASQAVYCVEKLGIPAEKVNPLGGAIALGHPLGCTGARQVVTLLNELKRRGRRAYGVVSMCIGTGMGAAAVFEYPGN
transit_peptide: 1..26 inference: non-experimental evidence, no additional details recorded note: Peroxisome (By similarity); propagated from UniProtKB/Swiss-Prot (Q921H8.1) calculated_mol_wt: 2729 peptide sequence: MHRLQVVLGHLAGRPESSSALQAAPC mat_peptide: 27..424 product: 3-ketoacyl-CoA thiolase A, peroxisomal experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q921H8.1) calculated_mol_wt: 41242 peptide sequence: SARFPQASASDVVVVHGRRTPIGRASRGGFKNTTPDELLSAVLTAVLQDVRLKPEQLGDISVGNVLEPGAGAVMARIAQFLSGIPETVPLSTVNRQCSSGLQAVANIAGGIRNGSYDIGMACGVESMSLSGMGNPGNISSRLLESEKARDCLTPMGMTSENVAERFGISRQKQDDFALASQQKAASAQSRGCFRAEIVPVTTTVLDDKGDKKTITVSQDEGVRPSTTMQGLAKLKPAFKDGGSTTAGNSSQVSDGAAAVLLARRSKAEELGLPILGVLRSYAVVGVPPDVMGIGPAYAIPAALQKAGLTVNDIDIFEINEAFASQAVYCVEKLGIPAEKVNPLGGAIALGHPLGCTGARQVVTLLNELKRRGRRAYGVVSMCIGTGMGAAAVFEYPGN

Gene Information

Entrez Gene ID
113868
Gene Name
acetyl-Coenzyme A acyltransferase 1A
Gene Symbol
Acaa1a
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005739 IDA:MGI C mitochondrion
GO:0005777 IDA:UniProtKB C peroxisome
GO:0003985 TAS:MGI F acetyl-CoA C-acetyltransferase activity
GO:0006631 TAS:MGI P fatty acid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu03320 PPAR signaling pathway
mmu04146 Peroxisome

Domain Information

InterPro Annotations

Accession Description
IPR002155 Thiolase
IPR020617 Thiolase, C-terminal
IPR020616 Thiolase, N-terminal
IPR020610 Thiolase, active site
IPR020615 Thiolase, acyl-enzyme intermediate active site
IPR020613 Thiolase, conserved site
IPR016039 Thiolase-like
IPR016038 Thiolase-like, subgroup

UniProt Annotations

Entry Information

Gene Name
acetyl-Coenzyme A acyltransferase 1A
Protein Entry
THIKA_MOUSE
UniProt ID
Q921H8
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.
Pathway Lipid metabolism; fatty acid metabolism.
Similarity Belongs to the thiolase family. {ECO:0000305}.
Subcellular Location Peroxisome {ECO:0000250}.
Subunit Homodimer. {ECO:0000250}.
Tissue Specificity Mainly expressed in liver and intestine. {ECO:0000269|PubMed:15043762}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000847 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
18700004 RefSeq NP_570934 424 3-ketoacyl-CoA thiolase A, peroxisomal precursor

Identical Sequences to LMP000847 proteins

Reference Database Accession Length Protein Name
GI:18700004 GenBank AAH12400.1 424 Acetyl-Coenzyme A acyltransferase 1A [Mus musculus]
GI:18700004 GenBank AAP31668.1 424 3-ketoacyl-CoA thiolase A [Mus musculus]
GI:18700004 GenBank AAP72964.1 424 peroxisomal 3-ketoacyl-CoA thiolase A [Mus musculus]
GI:18700004 GenBank EDL09221.1 424 mCG20972, isoform CRA_a [Mus musculus]
GI:18700004 RefSeq XP_006511986.1 424 PREDICTED: 3-ketoacyl-CoA thiolase A, peroxisomal isoform X1 [Mus musculus]
GI:18700004 SwissProt Q921H8.1 424 RecName: Full=3-ketoacyl-CoA thiolase A, peroxisomal; AltName: Full=Acetyl-CoA acyltransferase A; AltName: Full=Beta-ketothiolase A; AltName: Full=Peroxisomal 3-oxoacyl-CoA thiolase A; Flags: Precursor [Mus musculus]

Related Sequences to LMP000847 proteins

Reference Database Accession Length Protein Name
GI:18700004 DBBJ BAA14106.1 434 peroxisomal 3-ketoacyl-CoA thiolase A [Rattus norvegicus]
GI:18700004 DBBJ BAE25296.1 424 unnamed protein product [Mus musculus]
GI:18700004 GenBank AAA41471.1 434 3-ketoacyl-CoA thiolase 2 (EC 2.3.1.16) [Rattus norvegicus]
GI:18700004 GenBank EDL76915.1 434 rCG25819, isoform CRA_a [Rattus norvegicus]
GI:18700004 GenBank EDL76916.1 434 rCG25819, isoform CRA_a [Rattus norvegicus]
GI:18700004 SwissProt P21775.2 424 RecName: Full=3-ketoacyl-CoA thiolase A, peroxisomal; AltName: Full=Acetyl-CoA acyltransferase A; AltName: Full=Beta-ketothiolase A; AltName: Full=Peroxisomal 3-oxoacyl-CoA thiolase A; Flags: Precursor [Rattus norvegicus]