Gene/Proteome Database (LMPD)
LMPD ID
LMP000856
Gene ID
Species
Mus musculus (Mouse)
Gene Name
phospholipase C, gamma 2
Gene Symbol
Synonyms
PLCgamma2; Plcg-2
Alternate Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2; PLC-gamma-2; phospholipase C-gamma-2; phosphoinositide phospholipase C-gamma-2; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2
Chromosome
8
Map Location
8 E1|8 64.26 cM
EC Number
3.1.4.11
Proteins
| 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 | |
|---|---|
| Refseq ID | NP_758489 |
| Protein GI | 26986603 |
| UniProt ID | Q8CIH5 |
| mRNA ID | NM_172285 |
| Length | 1265 |
| RefSeq Status | PROVISIONAL |
| MTTMVNVDTLPEYEKSQIKRALELGTVMTVFNARKSTPERRTVQMIMETRQVAWSKTADKIEGFLDIMEIKEIRPGKNSKDFERAKAVRHKAECCFTILYGTQFVLSTLSLATDSKEDAVKWLSGLKILHQEAMSASTPTMIESWLRKQIYSVDQTRRNSISLRELKTILPLVNFKVSGIKFLKDKLVEIGAQKDELSFEQFHLFYKKLMFDQQKSILDEFKKDSSVFILGNTDRPDASAVYLQDFQRFLLHEQQELWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENSIWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSTEAYIRCLRAGCRCIELDCWDGPDGKPIIYHGWTRTTKIKFDDVVQAIRDHAFVTSSFPVILSIEEHCSVEQQRHMAKVFKEVLGDMLLTKPTEASADQLPSPSQLREKIIIKHKKLGPKGDVDVNVEDKKDEHKPQGELYMWDSIDQKWTRHYCAIADAKLSFGDDIEQAVEEEPVQDTPPTELHFGEKWFHKKVESRTSAEKLLQEYCAETGAKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMENGVMKYYLTDNLTFNSIYALIQHYREAHLRCAEFELRLTDPVPNPNPHESKPWYYDSLSRGEAEDMLMRIPRDGAFLIRKREGTNSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYYEKHALYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDYKAKRSDELTFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISAGDAEEMEKQIIEDNPLGSLCKGILDLNTYNVVKAPQGKNQKAFVFILEPKKQGDPPVEFATDRVEELFEWFQSIREITWKMDTKENNMKYWERNQSIAIELSDLVVYCKPTSKTKDHLENPDFREIRSFVETKADSIVRQKPVDLLRYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTPDKYMQMNHALFSLNGRTGYVLQPESMRSEKYDPMPLESQRKILMTLTVKVLGARHLPKLGRSIACPFVEVEICGAEYDSNKFKTTVVNDNGLSPVWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNFLAHATYPIKGIKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSCRQLRRRQEELNNQLFLYDTHQNLRGANRDALVKEFNVNENQLQLYQEKCNRRLREKRVSNSRFYS | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005829 | IMP:UniProtKB | C | cytosol |
| GO:0070062 | IEA:Ensembl | C | extracellular vesicular exosome |
| GO:0005886 | ISS:UniProtKB | C | plasma membrane |
| GO:0004435 | ISS:UniProtKB | F | phosphatidylinositol phospholipase C activity |
| GO:0004629 | TAS:MGI | F | phospholipase C activity |
| GO:0004871 | IEA:UniProtKB-KW | F | signal transducer activity |
| GO:0030183 | IMP:UniProtKB | P | B cell differentiation |
| GO:0050853 | IMP:UniProtKB | P | B cell receptor signaling pathway |
| GO:0050852 | IDA:MGI | P | T cell receptor signaling pathway |
| GO:0032237 | IMP:MGI | P | activation of store-operated calcium channel activity |
| GO:0002316 | IMP:MGI | P | follicular B cell differentiation |
| GO:0032959 | IDA:MGI | P | inositol trisphosphate biosynthetic process |
| GO:0035556 | IEA:InterPro | P | intracellular signal transduction |
| GO:0043069 | IMP:MGI | P | negative regulation of programmed cell death |
| GO:0006661 | ISS:UniProtKB | P | phosphatidylinositol biosynthetic process |
| GO:0009395 | IEA:InterPro | P | phospholipid catabolic process |
| GO:0010468 | IMP:MGI | P | regulation of gene expression |
| GO:0051209 | IMP:UniProtKB | P | release of sequestered calcium ion into cytosol |
| GO:0032496 | IDA:MGI | P | response to lipopolysaccharide |
KEGG Pathway Links
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR028381 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 |
| IPR000008 | C2 domain |
| IPR017946 | PLC-like phosphodiesterase, TIM beta/alpha-barrel domain |
| IPR016279 | Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma |
| IPR001192 | Phosphoinositide phospholipase C family |
| IPR000909 | Phospholipase C, phosphatidylinositol-specific , X domain |
| IPR001711 | Phospholipase C, phosphatidylinositol-specific, Y domain |
| IPR015359 | Phospholipase C, phosphoinositol-specific, EF-hand-like |
| IPR001849 | Pleckstrin homology domain |
| IPR011993 | Pleckstrin homology-like domain |
| IPR000980 | SH2 domain |
| IPR001452 | SH3_domain |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol. |
| Cofactor | Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250}; |
| Function | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling (By similarity). {ECO:0000250}. |
| Interaction | P14753:Epor; NbExp=2; IntAct=EBI-617954, EBI-617901; O70433:Fhl2; NbExp=3; IntAct=EBI-617954, EBI-299379; Q8BTM8:Flna; NbExp=3; IntAct=EBI-617954, EBI-641991; P11276:Fn1; NbExp=6; IntAct=EBI-617954, EBI-641955; Q9ES52:Inpp5d; NbExp=3; IntAct=EBI-617954, EBI-300210; P25911:Lyn; NbExp=2; IntAct=EBI-617954, EBI-643537; Q9WU78:Pdcd6ip; NbExp=7; IntAct=EBI-617954, EBI-641897; Q62158:Trim27; NbExp=4; IntAct=EBI-617954, EBI-642025; Q64321:Zbtb7b; NbExp=3; IntAct=EBI-617954, EBI-642868; |
| Ptm | Phosphorylated on tyrosine residues by BTK and SYK; upon ligand-induced activation of a variety of growth factor receptors and immune system receptors. Phosphorylation leads to increased phospholipase activity (By similarity). Phosphorylated on tyrosine residues by CSF1R. {ECO:0000250, ECO:0000269|PubMed:17947660, ECO:0000269|PubMed:9312046}. |
| Similarity | Contains 1 C2 domain. {ECO:0000255|PROSITE- ProRule:PRU00041}. |
| Similarity | Contains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}. |
| Similarity | Contains 1 PI-PLC X-box domain. {ECO:0000255|PROSITE- ProRule:PRU00270}. |
| Similarity | Contains 1 PI-PLC Y-box domain. {ECO:0000255|PROSITE- ProRule:PRU00271}. |
| Similarity | Contains 1 SH3 domain. {ECO:0000255|PROSITE- ProRule:PRU00192}. |
| Similarity | Contains 2 SH2 domains. {ECO:0000255|PROSITE- ProRule:PRU00191}. |
| Subunit | Interacts (via SH2 domain) with CSF1R (tyrosine phosphorylated). {ECO:0000269|PubMed:9312046}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP000856 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 26986603 | RefSeq | NP_758489 | 1265 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 |
Identical Sequences to LMP000856 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:26986603 | GenBank | AAH23877.1 | 1265 | Phospholipase C, gamma 2 [Mus musculus] |
| GI:26986603 | SwissProt | Q8CIH5.1 | 1265 | RecName: Full=1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2; AltName: Full=Phosphoinositide phospholipase C-gamma-2; AltName: Full=Phospholipase C-gamma-2; Short=PLC-gamma-2 [Mus musculus] |
Related Sequences to LMP000856 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:26986603 | DBBJ | BAE24959.1 | 1265 | unnamed protein product [Mus musculus] |
| GI:26986603 | EMBL | CBU87756.1 | 1265 | unnamed protein product [Rattus norvegicus] |
| GI:26986603 | EMBL | CBU96703.1 | 1265 | unnamed protein product [Rattus norvegicus] |
| GI:26986603 | GenBank | EDL11583.1 | 1361 | phospholipase C, gamma 2 [Mus musculus] |
| GI:26986603 | GenBank | EDL92653.1 | 1265 | phospholipase C, gamma 2 [Rattus norvegicus] |
| GI:26986603 | SwissProt | P24135.1 | 1265 | RecName: Full=1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2; AltName: Full=Phosphoinositide phospholipase C-gamma-2; AltName: Full=Phospholipase C-IV; Short=PLC-IV; AltName: Full=Phospholipase C-gamma-2; Short=PLC-gamma-2 [Rattus norvegicus] |