Gene/Proteome Database (LMPD)

LMPD ID
LMP000862
Gene ID
18759
Species
Mus musculus (Mouse)
Gene Name
protein kinase C, iota
Gene Symbol
Prkci
Synonyms
2310021H13Rik; AI427505; PKClambda; Pkci; Pkcl; Prkcl; aPKClambda; mKIAA4165
Chromosome
3
Map Location
3 A3|3 14.65 cM

Proteins

protein kinase C iota type
Refseq ID NP_032883
Protein GI 133778989
UniProt ID Q5DTK3
mRNA ID NM_008857
Length 595
RefSeq Status VALIDATED
MPTQRDSSTMSHTVACGGGGDHSHQVRVKAYYRGDIMITHFEPSISFEGLCSEVRDMCSFDNEQPFTMKWIDEEGDPCTVSSQLELEEAFRLYELNKDSELLIHVFPCVPERPGMPCPGEDKSIYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKLVTIECGRHSLPPEPMMPMDQTMHPDHTQTVIPYNPSSHESLDQVGEEKEAMNTRESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLMSAEECV

Gene Information

Entrez Gene ID
18759
Gene Name
protein kinase C, iota
Gene Symbol
Prkci
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0000139 IEA:Ensembl C Golgi membrane
GO:0045177 IDA:MGI C apical part of cell
GO:0016324 IDA:MGI C apical plasma membrane
GO:0031252 IEA:Ensembl C cell leading edge
GO:0005737 IDA:MGI C cytoplasm
GO:0005829 IEA:Ensembl C cytosol
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0045171 IEA:Ensembl C intercellular bridge
GO:0015630 IEA:Ensembl C microtubule cytoskeleton
GO:0005634 IDA:MGI C nucleus
GO:0043234 IEA:Ensembl C protein complex
GO:0005923 IEA:Ensembl C tight junction
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0005543 IEA:Ensembl F phospholipid binding
GO:0004697 IEA:Ensembl F protein kinase C activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0048194 IEA:Ensembl P Golgi vesicle budding
GO:0007015 IMP:MGI P actin filament organization
GO:0016477 IEA:Ensembl P cell migration
GO:0045216 IEA:Ensembl P cell-cell junction organization
GO:0034613 IEA:Ensembl P cellular protein localization
GO:0032869 IEA:Ensembl P cellular response to insulin stimulus
GO:0035089 IMP:MGI P establishment of apical/basal cell polarity
GO:0042462 IMP:MGI P eye photoreceptor cell development
GO:0035556 IEA:InterPro P intracellular signal transduction
GO:0034351 IEA:Ensembl P negative regulation of glial cell apoptotic process
GO:0043524 IEA:Ensembl P negative regulation of neuron apoptotic process
GO:0051092 IEA:Ensembl P positive regulation of NF-kappaB transcription factor activity
GO:2000353 IEA:Ensembl P positive regulation of endothelial cell apoptotic process
GO:0060252 IEA:Ensembl P positive regulation of glial cell proliferation
GO:0010976 IEA:Ensembl P positive regulation of neuron projection development
GO:0070555 IEA:Ensembl P response to interleukin-1

Domain Information

InterPro Annotations

Accession Description
IPR000961 AGC-kinase, C-terminal
IPR020454 Diacylglycerol/phorbol-ester binding
IPR000270 Phox/Bem1p
IPR012233 Protein kinase C
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR000719 Protein kinase domain
IPR017441 Protein kinase, ATP binding site
IPR017892 Protein kinase, C-terminal
IPR011009 Protein kinase-like domain
IPR008271 Serine/threonine-protein kinase, active site
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain

UniProt Annotations

Entry Information

Gene Name
protein kinase C, iota
Protein Entry
KPCI_MOUSE
UniProt ID
Q5DTK3
Species
Mouse

Comments

Comment Type Description
Catalytic Activity ATP + a protein = ADP + a phosphoprotein.
Similarity Contains AGC-kinase C-terminal domain.
Similarity Contains protein kinase domain.

Identical and Related Proteins

Unique RefSeq proteins for LMP000862 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
133778989 RefSeq NP_032883 595 protein kinase C iota type

Identical Sequences to LMP000862 proteins

Reference Database Accession Length Protein Name
GI:133778989 GenBank EDL34976.1 595 protein kinase C, iota [Mus musculus]
GI:133778989 SwissProt Q62074.3 595 RecName: Full=Protein kinase C iota type; AltName: Full=Atypical protein kinase C-lambda/iota; Short=aPKC-lambda/iota; AltName: Full=nPKC-iota [Mus musculus]

Related Sequences to LMP000862 proteins

Reference Database Accession Length Protein Name
GI:133778989 DBBJ BAD90305.1 674 mKIAA4165 protein, partial [Mus musculus]
GI:133778989 GenBank AAH21630.1 586 Protein kinase C, iota [Mus musculus]
GI:133778989 RefSeq NP_114448.1 596 protein kinase C iota type [Rattus norvegicus]
GI:133778989 RefSeq XP_005069807.1 596 PREDICTED: protein kinase C iota type [Mesocricetus auratus]
GI:133778989 RefSeq XP_005371734.1 596 PREDICTED: protein kinase C iota type [Microtus ochrogaster]
GI:133778989 SwissProt F1M7Y5.1 596 RecName: Full=Protein kinase C iota type; AltName: Full=Atypical protein kinase C-lambda/iota; Short=aPKC-lambda/iota; AltName: Full=nPKC-iota [Rattus norvegicus]