Gene/Proteome Database (LMPD)
LMPD ID
LMP000871
Gene ID
Species
Mus musculus (Mouse)
Gene Name
phospholipase D2
Gene Symbol
Synonyms
PLD1C
Alternate Names
phospholipase D2; choline phosphatase 2; phosphatidylcholine-hydrolyzing phospholipase D2
Chromosome
11
Map Location
11 B3|11 42.99 cM
EC Number
3.1.4.4
Summary
This gene is a member of the phospholipase D (PLD) superfamily. The encoded protein catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline. Phosphatidic acid is an essential intracellular lipid second messenger for many signaling pathways and has been implicated in a variety of physiological processes including cytoskeletal organization and cell proliferation. A similar gene in human may also function as a guanine nucleotide exchange factor (GEF) for the small GTPase Rac2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Orthologs
Proteins
| phospholipase D2 isoform 2 | |
|---|---|
| Refseq ID | NP_032902 |
| Protein GI | 6679379 |
| UniProt ID | P97813 |
| mRNA ID | NM_008876 |
| Length | 933 |
| RefSeq Status | REVIEWED |
| MTVTQKNLFPYGDYLNSSQLHMEPDEVDTLREGEDPADRMHPYLAIYDLQPLKAHPLVFAPGVPVIAQVVGTERYTSGSKVGTCTLYSVRLTHGDFTWTTKKKFRHFQELHRDLQRHKVLMSLLPLARFAVTHSPAREAAAEDIPSLPRGGSEGSARHTASKQKYLENYLNRLLTMSFYRNYHAMTEFLEVSQLSFIPDLGSKGLEGVIRKRSGGHRVPGFTFCGRDQVCYRWSKRWLVVKDSFLLYMRPETGAISFVQLFDPGFEVQVGKRSTETRYGVRIDTSHRSLILKCSSYRQARWWGQEITELAQGSGRDFLQLHQHDSYAPPRPGTLARWFVNGAGYFAAVADAILRAQEEIFITDWWLSPEIYLKRPAHSDDWRLDIMLKRKAEEGVRVSILLFKEVELALGINSGYSKRTLMLLHPNIKVMRHPDLVTLWAHHEKLLVVDQVVAFLGGLDLAFGRWDDVQYRLTDLGDPSEPVHLQTPTLGSDPAATPDLSHNQFFWLGKDYSNLITKDWVQLDRPFEDFIDRETTPRMPWRDVGVVVHGVAARDLARHFIQRWNFTKTTKARYKTPLYPYLLPKSTSTANNLPFMIPGGQCATVQVLRSVDRWSAGTLENSILNAYLHTIRESQHFLYIENQFFISCSDGRTVLNKVGDEIVDRILKAHEQGQCFRVYLLLPLLPGFEGDISTGGGNSIQAILHFTYRTLCRGEHSILHRLKAAMGTAWRDYMSICGLRTHGELGGHPISELIYIHSKMLIADDRTVIIGSANINDRSLLGKRDSELAILIKDTEMEPSLMDGVEYQAGRFALSLRKHCFSVILGANTWPDLDLRDPVCDDFFQLWQETAENNATIYEQIFRCLPSNATRSLRALREYVAVESLATVSPSLAQSELAHIQGHLVHFPLKFLEDESLLPPLGSKEGMIPLEVWT | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0031526 | IDA:MGI | C | brush border membrane |
| GO:0005789 | TAS:Reactome | C | endoplasmic reticulum membrane |
| GO:0005886 | IDA:MGI | C | plasma membrane |
| GO:0070290 | IEA:UniProtKB-EC | F | N-acylphosphatidylethanolamine-specific phospholipase D activity |
| GO:0035091 | IEA:InterPro | F | phosphatidylinositol binding |
| GO:0004630 | IDA:MGI | F | phospholipase D activity |
| GO:0002031 | IDA:MGI | P | G-protein coupled receptor internalization |
| GO:0016042 | IEA:UniProtKB-KW | P | lipid catabolic process |
| GO:0006898 | IDA:MGI | P | receptor-mediated endocytosis |
KEGG Pathway Links
Domain Information
InterPro Annotations
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=1; Comment=At least 3 isoforms are produced.; Name=1; IsoId=P97813-1; Sequence=Displayed; |
| Catalytic Activity | A phosphatidylcholine + H(2)O = choline + a phosphatidate. |
| Developmental Stage | Expressed at high levels in the hippocampus at the earliest time at which it is defined as a structure and also in ventricular neural cells as well as differentiating neurons outside of the ventricular region. Expressed during development in lower levels in mesenchymal cells derived from the neural crest that are destined to form bones of the skull. |
| Enzyme Regulation | Stimulated by phosphatidylinositol 4,5- bisphosphate. Is not responsive to either ADP-ribosylation factor- 1 (ARF-1) or GTP-binding proteins such as RHOA. |
| Function | May have a role in signal-induced cytoskeletal regulation and/or endocytosis. |
| Ptm | Phosphorylated by FGR (By similarity). Phosphorylated on Tyr- 11; most likely by EGFR. {ECO:0000250, ECO:0000269|PubMed:9837959}. |
| Similarity | Belongs to the phospholipase D family. {ECO:0000305}. |
| Similarity | Contains 1 PH domain. {ECO:0000305}. |
| Similarity | Contains 1 PX (phox homology) domain. {ECO:0000255|PROSITE-ProRule:PRU00147}. |
| Similarity | Contains 2 PLD phosphodiesterase domains. {ECO:0000255|PROSITE-ProRule:PRU00153}. |
| Subcellular Location | Membrane; Peripheral membrane protein. |
| Subunit | Interacts with PIP5K1B (By similarity). Interacts with EGFR. {ECO:0000250}. |
| Tissue Specificity | Ubiquitous. Highest levels in brain and lung. {ECO:0000269|PubMed:9307024}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP000871 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 6679379 | RefSeq | NP_032902 | 933 | phospholipase D2 isoform 2 |
Identical Sequences to LMP000871 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6679379 | DBBJ | BAE41964.1 | 933 | unnamed protein product [Mus musculus] |
| GI:6679379 | GenBank | AAC53173.1 | 933 | phosphatidylcholine-specific phospholipase D2 [Mus musculus] |
| GI:6679379 | GenBank | AAC24519.1 | 933 | phospholipase D2 [Mus musculus] |
| GI:6679379 | GenBank | ABK42332.1 | 933 | PLD-2 [synthetic construct] |
| GI:6679379 | GenBank | EDL12578.1 | 933 | phospholipase D2 [Mus musculus] |
| GI:6679379 | SwissProt | P97813.2 | 933 | RecName: Full=Phospholipase D2; Short=PLD 2; Short=mPLD2; AltName: Full=Choline phosphatase 2; AltName: Full=PLD1C; AltName: Full=Phosphatidylcholine-hydrolyzing phospholipase D2 [Mus musculus] |
Related Sequences to LMP000871 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6679379 | DBBJ | BAE25613.1 | 933 | unnamed protein product [Mus musculus] |
| GI:6679379 | GenBank | AAM57888.1 | 932 | Sequence 6 from patent US 6379665 |
| GI:6679379 | GenBank | AAH68317.1 | 944 | Pld2 protein [Mus musculus] |
| GI:6679379 | RefSeq | XP_006532547.1 | 944 | PREDICTED: phospholipase D2 isoform X2 [Mus musculus] |
| GI:6679379 | RefSeq | XP_006537200.1 | 944 | PREDICTED: phospholipase D2 isoform X2 [Mus musculus] |
| GI:6679379 | RefSeq | NP_001289404.1 | 944 | phospholipase D2 isoform 1 [Mus musculus] |