Gene/Proteome Database (LMPD)

LMPD ID
LMP000873
Gene ID
111175
Species
Mus musculus (Mouse)
Gene Name
peroxisomal trans-2-enoyl-CoA reductase
Gene Symbol
Pecr
Synonyms
2400003B18Rik; TERP
Alternate Names
peroxisomal trans-2-enoyl-CoA reductase; perosisomal 2-enoyl-CoA reductase
Chromosome
1
Map Location
1 C3|1 36.46 cM
EC Number
1.3.1.38

Proteins

peroxisomal trans-2-enoyl-CoA reductase
Refseq ID NP_076012
Protein GI 227908837
UniProt ID Q99MZ7
mRNA ID NM_023523
Length 303
RefSeq Status VALIDATED
MGSWKTGQSYLAAGLLKNQVAVVTGGGTGIGKAVSRELLHLGCNVVIASRKLDRLTAAVDELRASLPPSSSAEVSAIQCNIRKEEEVSNLVKSTLAKYGKINFLVNNGGGQFMAPVEDITAKGWHAVIETNLTGTFYMCKEVYNSWMREHGGSIVNIIVLLNNGFPTAAHTGAAREGVYNLTKSMALAWASSGVRINCVAPGTIYSQTAVDNYGEMGQTLFEMAFDSIPAKRLGVPEEISPLVCFLLSPAASYITGQLINVDGGQALYTHAFSIPDHDNWPVGAGDLSIVKRIKESFKKKAKL

Gene Information

Entrez Gene ID
111175
Gene Name
peroxisomal trans-2-enoyl-CoA reductase
Gene Symbol
Pecr
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0043231 ISS:UniProtKB C intracellular membrane-bounded organelle
GO:0005739 IDA:UniProtKB C mitochondrion
GO:0005778 ISS:UniProtKB C peroxisomal membrane
GO:0005777 ISA:MGI C peroxisome
GO:0019166 ISS:UniProtKB F trans-2-enoyl-CoA reductase (NADPH) activity
GO:0030497 ISA:MGI P fatty acid elongation
GO:0033306 IEA:Ensembl P phytol metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu01040 Biosynthesis of unsaturated fatty acids
mmu01212 Fatty acid metabolism
mmu04146 Peroxisome

Domain Information

InterPro Annotations

Accession Description
IPR002347 Glucose/ribitol dehydrogenase
IPR016040 NAD(P)-binding domain

UniProt Annotations

Entry Information

Gene Name
peroxisomal trans-2-enoyl-CoA reductase
Protein Entry
PECR_MOUSE
UniProt ID
Q99MZ7
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Acyl-CoA + NADP(+) = trans-2,3-dehydroacyl-CoA + NADPH.
Function Participates in chain elongation of fatty acids. Has no 2,4-dienoyl-CoA reductase activity (By similarity). {ECO:0000250}.
Pathway Lipid metabolism; fatty acid biosynthesis.
Similarity Belongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000305}.
Subcellular Location Peroxisome {ECO:0000250}.
Subunit Interacts with PEX5, probably required to target it into peroxisomes. {ECO:0000250}.
Tissue Specificity Highly expressed in liver and kidney. Expressed at lowe level in heart and skeletal muscle. Expressed at weak level in other tissues. {ECO:0000269|PubMed:10811639}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000873 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
227908837 RefSeq NP_076012 303 peroxisomal trans-2-enoyl-CoA reductase

Identical Sequences to LMP000873 proteins

Reference Database Accession Length Protein Name
GI:227908837 GenBank AAK28336.1 303 peroxisomal 2-enoyl-CoA reductase [Mus musculus]
GI:227908837 GenBank AAH13530.1 303 Peroxisomal trans-2-enoyl-CoA reductase [Mus musculus]
GI:227908837 GenBank EDL00278.1 303 peroxisomal trans-2-enoyl-CoA reductase, isoform CRA_b [Mus musculus]
GI:227908837 GenBank EDL00279.1 303 peroxisomal trans-2-enoyl-CoA reductase, isoform CRA_c [Mus musculus]
GI:227908837 SwissProt Q99MZ7.1 303 RecName: Full=Peroxisomal trans-2-enoyl-CoA reductase; Short=TERP [Mus musculus]

Related Sequences to LMP000873 proteins

Reference Database Accession Length Protein Name
GI:227908837 DBBJ BAB26803.1 303 unnamed protein product [Mus musculus]
GI:227908837 GenBank AAD38447.1 303 putative short-chain dehydrogenase/reductase [Rattus norvegicus]
GI:227908837 GenBank AAF14047.1 303 peroxisomal 2,4-dienoyl CoA reductase px-2,4-DCR#1 [Rattus norvegicus]
GI:227908837 GenBank AAF69800.1 303 peroxisomal trans 2-enoyl CoA reductase [Mus musculus]
GI:227908837 GenBank AAO99156.1 303 Sequence 25 from patent US 6511834
GI:227908837 GenBank ACP59667.1 303 Sequence 13 from patent US 7494793