Gene/Proteome Database (LMPD)

LMPD ID
LMP000876
Gene ID
117147
Species
Mus musculus (Mouse)
Gene Name
acyl-CoA synthetase medium-chain family member 1
Gene Symbol
Acsm1
Synonyms
Acas3; Bucs1; Macs
Alternate Names
acyl-coenzyme A synthetase ACSM1, mitochondrial; butyrate--CoA ligase 1; lipoate-activating enzyme; acetyl-Coenzyme A synthetase 3; butyryl Coenzyme A synthetase 1; butyryl-coenzyme A synthetase 1; middle-chain acyl-CoA synthetase 1
Chromosome
7
Map Location
7|7 F3
EC Number
6.2.1.2

Proteins

acyl-coenzyme A synthetase ACSM1, mitochondrial
Refseq ID NP_473435
Protein GI 16905127
UniProt ID Q91VA0
mRNA ID NM_054094
Length 573
RefSeq Status PROVISIONAL
MQWLKSFQICKVLQGFSLSPTQLHRRLFSRVGAPRWNDHDSPEEFNFASDVLDYWAQMEEEGKRGPSPAFWWVNGQGDEIKWSFRKLRDLTCRTANVFEQICGLQQGDHLALILPRVPEWWLVTVGCMRTGIIFMPGTTQLKAKDILYRIQISRAKAIVTTASLVPEVESVASECPDLKTKLVVSDHSHEGWLDFCSLIKSASPDHTCIKSKMKDPMAIFFTSGTTGYPKMAKHNQGLAFRSYIPSCRKLLKLKTSDILWCMSDPGWILATVGCLIEPWTSGCTVFIHHLPQFDPKVIVEVLFKYPITQCLAAPGVYRMVLQQKTSNLRFPTLEHCTTGGESLLPEEYEQWKQRTGLSIHEVYGQSETGISSATLREMKIKRGSIGKAILPFDLQIIDEKGNILPPNTEGYIGIRIKPTRPLGLFMEYENSPESTSEVECGDFYNSGDRATIDEEGYIWFLGRGDDVINASGYRIGPVEVENALAEHPAVAESAVVSSPDKDRGEVVKAFIVLNPEFLSHDQEQLIKELQHHVKSVTAPYKYPRKVEFVSELPKTVTGKIKRKELRNKEFGQL
transit_peptide: 1..35 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (Potential); propagated from UniProtKB/Swiss-Prot (Q91VA0.1) calculated_mol_wt: 4117 peptide sequence: MQWLKSFQICKVLQGFSLSPTQLHRRLFSRVGAPR mat_peptide: 36..573 product: Acyl-coenzyme A synthetase ACSM1, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q91VA0.1) calculated_mol_wt: 60662 peptide sequence: WNDHDSPEEFNFASDVLDYWAQMEEEGKRGPSPAFWWVNGQGDEIKWSFRKLRDLTCRTANVFEQICGLQQGDHLALILPRVPEWWLVTVGCMRTGIIFMPGTTQLKAKDILYRIQISRAKAIVTTASLVPEVESVASECPDLKTKLVVSDHSHEGWLDFCSLIKSASPDHTCIKSKMKDPMAIFFTSGTTGYPKMAKHNQGLAFRSYIPSCRKLLKLKTSDILWCMSDPGWILATVGCLIEPWTSGCTVFIHHLPQFDPKVIVEVLFKYPITQCLAAPGVYRMVLQQKTSNLRFPTLEHCTTGGESLLPEEYEQWKQRTGLSIHEVYGQSETGISSATLREMKIKRGSIGKAILPFDLQIIDEKGNILPPNTEGYIGIRIKPTRPLGLFMEYENSPESTSEVECGDFYNSGDRATIDEEGYIWFLGRGDDVINASGYRIGPVEVENALAEHPAVAESAVVSSPDKDRGEVVKAFIVLNPEFLSHDQEQLIKELQHHVKSVTAPYKYPRKVEFVSELPKTVTGKIKRKELRNKEFGQL

Gene Information

Entrez Gene ID
117147
Gene Name
acyl-CoA synthetase medium-chain family member 1
Gene Symbol
Acsm1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0072562 IEA:Ensembl C blood microparticle
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005759 ISS:UniProtKB C mitochondrial matrix
GO:0005739 IDA:MGI C mitochondrion
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0005525 IEA:UniProtKB-KW F GTP binding
GO:0003996 ISS:UniProtKB F acyl-CoA ligase activity
GO:0047760 ISS:UniProtKB F butyrate-CoA ligase activity
GO:0015645 IDA:MGI F fatty acid ligase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0006633 IDA:MGI P fatty acid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu00650 Butanoate metabolism
mmu01100 Metabolic pathways

BIOCYC Pathway Links

BIOCYC Pathway ID Description
FAO-PWY fatty acid beta-oxidation I

REACTOME Pathway Links

REACTOME Pathway ID Description
5893231 Conjugation of benzoate with glycine

Domain Information

InterPro Annotations

Accession Description
IPR025110 AMP-binding enzyme C-terminal domain
IPR020845 AMP-binding, conserved site
IPR000873 AMP-dependent synthetase/ligase

UniProt Annotations

Entry Information

Gene Name
acyl-CoA synthetase medium-chain family member 1
Protein Entry
ACSM1_MOUSE
UniProt ID
Q91VA0
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q91VA0-1; Sequence=Displayed; Name=2; IsoId=Q91VA0-2; Sequence=VSP_028392; Note=No experimental confirmation available.;
Catalytic Activity ATP + a carboxylate + CoA = AMP + diphosphate + an acyl-CoA.
Catalytic Activity GTP + lipoate = diphosphate + lipoyl-GMP.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
Function Functions as GTP-dependent lipoate-activating enzyme that generates the substrate for lipoyltransferase (By similarity). Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro). {ECO:0000250, ECO:0000269|PubMed:11470804}.
Similarity Belongs to the ATP-dependent AMP-binding enzyme family. {ECO:0000305}.
Subcellular Location Mitochondrion matrix {ECO:0000269|PubMed:11470804}.
Subunit Monomer. {ECO:0000250}.
Tissue Specificity Highly expressed in liver and kidney. {ECO:0000269|PubMed:11470804}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000876 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
16905127 RefSeq NP_473435 573 acyl-coenzyme A synthetase ACSM1, mitochondrial

Identical Sequences to LMP000876 proteins

Reference Database Accession Length Protein Name
GI:16905127 DBBJ BAB64534.1 573 medium-chain acyl-CoA synthetase [Mus musculus]
GI:16905127 DBBJ BAE28952.1 573 unnamed protein product [Mus musculus]
GI:16905127 GenBank AAH16414.1 573 Acyl-CoA synthetase medium-chain family member 1 [Mus musculus]
GI:16905127 GenBank AAH22149.1 573 Acyl-CoA synthetase medium-chain family member 1 [Mus musculus]
GI:16905127 SwissProt Q91VA0.1 573 RecName: Full=Acyl-coenzyme A synthetase ACSM1, mitochondrial; AltName: Full=Acyl-CoA synthetase medium-chain family member 1; AltName: Full=Butyrate--CoA ligase 1; AltName: Full=Butyryl-coenzyme A synthetase 1; AltName: Full=Lipoate-activating enzyme; AltName: Full=Middle-chain acyl-CoA synthetase 1; Flags: Precursor [Mus musculus]

Related Sequences to LMP000876 proteins

Reference Database Accession Length Protein Name
GI:16905127 DBBJ BAE28977.1 531 unnamed protein product, partial [Mus musculus]
GI:16905127 GenBank EDL17174.1 573 acyl-CoA synthetase medium-chain family member 1 [Mus musculus]
GI:16905127 GenBank AAI68985.1 577 Bucs1 protein [Rattus norvegicus]
GI:16905127 RefSeq NP_001101972.2 577 acyl-coenzyme A synthetase ACSM1, mitochondrial [Rattus norvegicus]
GI:16905127 RefSeq XP_006985765.1 578 PREDICTED: acyl-coenzyme A synthetase ACSM1, mitochondrial-like isoform X1 [Peromyscus maniculatus bairdii]
GI:16905127 RefSeq XP_008757995.1 661 PREDICTED: acyl-coenzyme A synthetase ACSM1, mitochondrial isoform X6 [Rattus norvegicus]