Gene/Proteome Database (LMPD)

LMPD ID
LMP000877
Gene ID
53357
Species
Mus musculus (Mouse)
Gene Name
phospholipase A2, group VI
Gene Symbol
Pla2g6
Synonyms
BB112799; PNPLA9; iPLA(2)beta; iPLA2; iPLA2beta
Alternate Names
85/88 kDa calcium-independent phospholipase A2; GVI PLA2; caI-PLA2; iPLA2-beta; group VI phospholipase A2; 85 kDa calcium-independent phospholipase A2; patatin-like phospholipase domain-containing protein 9; intracellular membrane-associated calcium-independent phospholipase A2 beta
Chromosome
15
Map Location
15 E1|15
EC Number
3.1.1.4

Proteins

85/88 kDa calcium-independent phospholipase A2 isoform 1
Refseq ID NP_001185953
Protein GI 312222743
UniProt ID P97819
mRNA ID NM_001199024
Length 752
RefSeq Status VALIDATED
MQFFGRLVNTLSSVTNLFSNPFRVKEVSLTDYVSSERVREEGQLILLQNVSNRTWDCVLVSPRNPQSGFRLFQLESEADALVNFQQFSSQLPPFYESSVQVLHVEVLQHLTDLIRNHPSWTVTHLAVELGIRECFHHSRIISCANSTENEEGCTPLHLACRKGDSEILVELVQYCHAQMDVTDNKGETAFHYAVQGDNPQVLQLLGKNASAGLNQVNNQGLTPLHLACKMGKQEMVRVLLLCNARCNIMGPGGFPIHTAMKFSQKGCAEMIISMDSNQIHSKDPRYGASPLHWAKNAEMARMLLKRGCDVDSTSSSGNTALHVAVMRNRFDCVMVLLTYGANAGARGEHGNTPLHLAMSKDNMEMVKALIVFGAEVDTPNDFGETPALIASKISKQLQDLMPISRARKPAFILSSMRDEKRSHDHLLCLDGGGVKGLVIIQLLIAIEKASGVATKDLFDWVAGTSTGGILALAILHSKSMAYMRGVYFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVKKPKVMLTGTLSDRQPAELHLFRNYDAPEAVREPRCNQNINLKPPTQPADQLVWRAARSSGAAPTYFRPNGRFLDGGLLANNPTLDAMTEIHEYNQDMIRKGQGNKVKKLSIVVSLGTGKSPQVPVTCVDVFRPSNPWELAKTVFGAKELGKMVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQLGSDIMLDEVSDAVLVNALWETEVYIYEHREEFQKLVQLLLSP
85/88 kDa calcium-independent phospholipase A2 isoform 1
Refseq ID NP_058611
Protein GI 8393978
UniProt ID P97819
mRNA ID NM_016915
Length 752
RefSeq Status VALIDATED
Protein sequence is identical to GI:312222743 (mRNA isoform)
85/88 kDa calcium-independent phospholipase A2 isoform 1
Refseq ID NP_001185954
Protein GI 312222745
UniProt ID P97819
mRNA ID NM_001199025
Length 752
RefSeq Status VALIDATED
Protein sequence is identical to GI:312222743 (mRNA isoform)
85/88 kDa calcium-independent phospholipase A2 isoform 2
Refseq ID NP_001185952
Protein GI 312222739
UniProt ID P97819
mRNA ID NM_001199023
Length 807
RefSeq Status VALIDATED
MQFFGRLVNTLSSVTNLFSNPFRVKEVSLTDYVSSERVREEGQLILLQNVSNRTWDCVLVSPRNPQSGFRLFQLESEADALVNFQQFSSQLPPFYESSVQVLHVEVLQHLTDLIRNHPSWTVTHLAVELGIRECFHHSRIISCANSTENEEGCTPLHLACRKGDSEILVELVQYCHAQMDVTDNKGETAFHYAVQGDNPQVLQLLGKNASAGLNQVNNQGLTPLHLACKMGKQEMVRVLLLCNARCNIMGPGGFPIHTAMKFSQKGCAEMIISMDSNQIHSKDPRYGASPLHWAKNAEMARMLLKRGCDVDSTSSSGNTALHVAVMRNRFDCVMVLLTYGANAGARGEHGNTPLHLAMSKDNMEMVKALIVFGAEVDTPNDFGETPALIASKISKLITRKALLTLLKTVGADHHFPIIQGVSTEQGSAAATHPLFSLDRTQPPAISLNNLELQDLMPISRARKPAFILSSMRDEKRSHDHLLCLDGGGVKGLVIIQLLIAIEKASGVATKDLFDWVAGTSTGGILALAILHSKSMAYMRGVYFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVKKPKVMLTGTLSDRQPAELHLFRNYDAPEAVREPRCNQNINLKPPTQPADQLVWRAARSSGAAPTYFRPNGRFLDGGLLANNPTLDAMTEIHEYNQDMIRKGQGNKVKKLSIVVSLGTGKSPQVPVTCVDVFRPSNPWELAKTVFGAKELGKMVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQLGSDIMLDEVSDAVLVNALWETEVYIYEHREEFQKLVQLLLSP

Gene Information

Entrez Gene ID
53357
Gene Name
phospholipase A2, group VI
Gene Symbol
Pla2g6
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IEA:Ensembl C cytosol
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0005739 IEA:Ensembl C mitochondrion
GO:0047499 IEA:Ensembl F calcium-independent phospholipase A2 activity
GO:0032049 IEA:Ensembl P cardiolipin biosynthetic process
GO:0006935 IEA:UniProtKB-KW P chemotaxis
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process
GO:0060135 IEA:Ensembl P maternal process involved in female pregnancy
GO:0007613 IEA:Ensembl P memory
GO:0051967 IEA:Ensembl P negative regulation of synaptic transmission, glutamatergic
GO:0090238 IEA:Ensembl P positive regulation of arachidonic acid secretion
GO:2000304 IEA:Ensembl P positive regulation of ceramide biosynthetic process
GO:0007204 IEA:Ensembl P positive regulation of cytosolic calcium ion concentration
GO:0045921 IEA:Ensembl P positive regulation of exocytosis
GO:0035774 IEA:Ensembl P positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0090037 IEA:Ensembl P positive regulation of protein kinase C signaling
GO:0001934 IEA:Ensembl P positive regulation of protein phosphorylation
GO:0090200 IEA:Ensembl P positive regulation of release of cytochrome c from mitochondria
GO:0045909 IEA:Ensembl P positive regulation of vasodilation
GO:1901339 IEA:Ensembl P regulation of store-operated calcium channel activity
GO:0034976 IEA:Ensembl P response to endoplasmic reticulum stress
GO:0014832 IEA:Ensembl P urinary bladder smooth muscle contraction

KEGG Pathway Links

KEGG Pathway ID Description
mmu04750 Inflammatory mediator regulation of TRP channels
mmu04014 Ras signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase
IPR002110 Ankyrin repeat
IPR020683 Ankyrin repeat-containing domain
IPR002641 Patatin/Phospholipase A2-related

UniProt Annotations

Entry Information

Gene Name
phospholipase A2, group VI
Protein Entry
PLPL9_MOUSE
UniProt ID
P97819
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=Long; Synonyms=iPLA2-L; IsoId=P97819-1; Sequence=Displayed; Name=Short; Synonyms=iPLA2-S; IsoId=P97819-2; Sequence=VSP_044364;
Catalytic Activity Phosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate.
Enzyme Regulation Inhibited by calcium-activated calmodulin. {ECO:0000250}.
Function Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F- actin polymerization at the pseudopods (By similarity). {ECO:0000250}.
Similarity Contains 1 patatin domain. {ECO:0000305}.
Similarity Contains 7 ANK repeats. {ECO:0000255|PROSITE- ProRule:PRU00023}.
Subcellular Location Isoform Long: Membrane; Peripheral membrane protein. Note=Recruited to the membrane-enriched pseudopod upon MCP1/CCL2 stimulation in monocytes. {ECO:0000250}.
Subcellular Location Isoform Short: Cytoplasm.

Identical and Related Proteins

Unique RefSeq proteins for LMP000877 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
312222743 RefSeq NP_001185953 752 85/88 kDa calcium-independent phospholipase A2 isoform 1
312222739 RefSeq NP_001185952 807 85/88 kDa calcium-independent phospholipase A2 isoform 2

Identical Sequences to LMP000877 proteins

Reference Database Accession Length Protein Name
GI:312222743 GenBank AEU43295.1 752 Sequence 44 from patent US 8052970
GI:312222743 GenBank AEU43323.1 752 Sequence 72 from patent US 8052970
GI:312222743 GenBank AEU43390.1 752 Sequence 139 from patent US 8052970
GI:312222743 GenBank AEU43412.1 752 Sequence 161 from patent US 8052970
GI:312222743 GenBank AEU43431.1 752 Sequence 180 from patent US 8052970
GI:312222743 GenBank AEU43530.1 752 Sequence 279 from patent US 8052970
GI:312222739 RefSeq XP_006521218.1 807 PREDICTED: 85/88 kDa calcium-independent phospholipase A2 isoform X4 [Mus musculus]
GI:312222739 RefSeq XP_006521219.1 807 PREDICTED: 85/88 kDa calcium-independent phospholipase A2 isoform X5 [Mus musculus]
GI:312222739 RefSeq XP_006521220.1 807 PREDICTED: 85/88 kDa calcium-independent phospholipase A2 isoform X6 [Mus musculus]
GI:312222739 RefSeq XP_006521221.1 807 PREDICTED: 85/88 kDa calcium-independent phospholipase A2 isoform X7 [Mus musculus]
GI:312222739 RefSeq XP_006521222.1 807 PREDICTED: 85/88 kDa calcium-independent phospholipase A2 isoform X8 [Mus musculus]
GI:312222739 RefSeq XP_006521223.1 807 PREDICTED: 85/88 kDa calcium-independent phospholipase A2 isoform X9 [Mus musculus]

Related Sequences to LMP000877 proteins

Reference Database Accession Length Protein Name
GI:312222743 DBBJ BAE31912.1 752 unnamed protein product [Mus musculus]
GI:312222739 GenBank AAH81916.1 807 Phospholipase A2, group VI (cytosolic, calcium-independent) [Rattus norvegicus]
GI:312222743 GenBank EDL04656.1 777 phospholipase A2, group VI, isoform CRA_a, partial [Mus musculus]
GI:312222739 GenBank EDL04657.1 832 phospholipase A2, group VI, isoform CRA_b, partial [Mus musculus]
GI:312222743 GenBank EDL04658.1 795 phospholipase A2, group VI, isoform CRA_c, partial [Mus musculus]
GI:312222739 GenBank AEU43314.1 807 Sequence 63 from patent US 8052970
GI:312222743 GenBank AEU43413.1 795 Sequence 162 from patent US 8052970
GI:312222739 GenBank AEU43414.1 832 Sequence 163 from patent US 8052970
GI:312222743 GenBank AEU43415.1 777 Sequence 164 from patent US 8052970
GI:312222739 GenBank AEU43438.1 807 Sequence 187 from patent US 8052970
GI:312222743 GenBank AEU43531.1 752 Sequence 280 from patent US 8052970
GI:312222739 RefSeq NP_001005560.1 807 85/88 kDa calcium-independent phospholipase A2 isoform 1 [Rattus norvegicus]