Gene/Proteome Database (LMPD)

LMPD ID
LMP000880
Gene ID
20415
Species
Mus musculus (Mouse)
Gene Name
sex hormone binding globulin
Gene Symbol
Shbg
Synonyms
ABP
Alternate Names
sex hormone-binding globulin; SBP; sex steroid-binding protein; testis-specific androgen-binding protein
Chromosome
11
Map Location
11 B3|11 42.86 cM

Proteins

sex hormone-binding globulin precursor
Refseq ID NP_035497
Protein GI 6755506
UniProt ID P97497
mRNA ID NM_011367
Length 403
RefSeq Status VALIDATED
MEKRDSVALHWRLLLLLLLLMPPPTHQGRALRHIDPIQSAQDPPAKYLSNGPGQEPVMVMTIDLTKISKPHSSFEFRTWDPEGVIFYGDTNTEDDWFLLGLRAGQLEIQLHNAWARLTVGFGPRLDDGRWHPVELKMNGDSLLLWVDGKEMLCLRQISASLADHSQRSMRIALGGLLLPTSKLRFPLVPALDGCIRRDIWLGHQAQLSASPRTSLGNCDVDLQPGLFFPPGTHAEFSLQDIPQPHADPWTFSLELGFKLVDGSGQLLALGTGTNSSWLNIHLQNQSVVLSSEAEPKVVLPLDVGLPLQLTLDRVKVVLSQGPKMEVLSMSLLRPASLWRLWSHPQGHLSLGALPGESSSASFCLSDFWVQGQRLDIDQALSRSQDIWTHSCPQRPSNDTRTSH
sig_peptide: 1..30 inference: non-experimental evidence, no additional details recorded note: By similarity; propagated from UniProtKB/Swiss-Prot (P97497.1) calculated_mol_wt: 3506 peptide sequence: MEKRDSVALHWRLLLLLLLLMPPPTHQGRA mat_peptide: 31..403 product: Sex hormone-binding globulin experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P97497.1) calculated_mol_wt: 41328 peptide sequence: LRHIDPIQSAQDPPAKYLSNGPGQEPVMVMTIDLTKISKPHSSFEFRTWDPEGVIFYGDTNTEDDWFLLGLRAGQLEIQLHNAWARLTVGFGPRLDDGRWHPVELKMNGDSLLLWVDGKEMLCLRQISASLADHSQRSMRIALGGLLLPTSKLRFPLVPALDGCIRRDIWLGHQAQLSASPRTSLGNCDVDLQPGLFFPPGTHAEFSLQDIPQPHADPWTFSLELGFKLVDGSGQLLALGTGTNSSWLNIHLQNQSVVLSSEAEPKVVLPLDVGLPLQLTLDRVKVVLSQGPKMEVLSMSLLRPASLWRLWSHPQGHLSLGALPGESSSASFCLSDFWVQGQRLDIDQALSRSQDIWTHSCPQRPSNDTRTSH

Gene Information

Entrez Gene ID
20415
Gene Name
sex hormone binding globulin
Gene Symbol
Shbg
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005496 IEA:UniProtKB-KW F steroid binding
GO:0007285 IEA:Ensembl P primary spermatocyte growth

Domain Information

InterPro Annotations

Accession Description
IPR013320 Concanavalin A-like lectin/glucanase domain
IPR001791 Laminin G domain

UniProt Annotations

Entry Information

Gene Name
sex hormone binding globulin
Protein Entry
SHBG_MOUSE
UniProt ID
P97497
Species
Mouse

Comments

Comment Type Description
Function Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration (By similarity). {ECO:0000250}.
Similarity Contains 2 laminin G-like domains. {ECO:0000255|PROSITE-ProRule:PRU00122}.
Subcellular Location Secreted {ECO:0000250}. Note=In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis. {ECO:0000250}.
Subunit Homodimer. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000880 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6755506 RefSeq NP_035497 403 sex hormone-binding globulin precursor

Identical Sequences to LMP000880 proteins

Reference Database Accession Length Protein Name
GI:6755506 EMBL CAI52019.1 403 sex hormone binding globulin [Mus musculus]
GI:6755506 GenBank AAB42088.1 403 testis-specific androgen-binding protein [Mus musculus]
GI:6755506 GenBank AAI20786.1 403 Sex hormone binding globulin [Mus musculus]
GI:6755506 GenBank AAI20788.1 403 Sex hormone binding globulin [Mus musculus]
GI:6755506 SwissProt P97497.1 403 RecName: Full=Sex hormone-binding globulin; Short=SHBG; AltName: Full=Sex steroid-binding protein; Short=SBP; AltName: Full=Testis-specific androgen-binding protein; Short=ABP; Flags: Precursor [Mus musculus]

Related Sequences to LMP000880 proteins

Reference Database Accession Length Protein Name
GI:6755506 GenBank AAA40648.1 403 androgen binding protein precursor [Rattus norvegicus]
GI:6755506 GenBank AAA40650.1 403 androgen binding protein [Rattus norvegicus]
GI:6755506 GenBank AAH97336.1 403 Sex hormone binding globulin [Rattus norvegicus]
GI:6755506 GenBank EDM04875.1 403 sex hormone binding globulin [Rattus norvegicus]
GI:6755506 RefSeq NP_036782.1 403 sex hormone-binding globulin precursor [Rattus norvegicus]
GI:6755506 SwissProt P08689.1 403 RecName: Full=Sex hormone-binding globulin; Short=SHBG; AltName: Full=Sex steroid-binding protein; Short=SBP; AltName: Full=Testis-specific androgen-binding protein; Short=ABP; Flags: Precursor [Rattus norvegicus]