Gene/Proteome Database (LMPD)

LMPD ID
LMP000885
Gene ID
8895
Species
Homo sapiens (Human)
Gene Name
copine III
Gene Symbol
CPNE3
Synonyms
CPN3; PRO1071
Alternate Names
copine-3
Chromosome
8
Map Location
8q21.3
Summary
Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene encodes a protein which contains two type II C2 domains in the amino-terminus and an A domain-like sequence in the carboxy-terminus. The A domain mediates interactions between integrins and extracellular ligands. [provided by RefSeq, Aug 2008]
Orthologs
View orthologs and multiple alignments for CPNE3

Proteins

copine-3
Refseq ID NP_003900
Protein GI 4503015
UniProt ID O75131
mRNA ID NM_003909
Length 537
RefSeq Status REVIEWED
MAAQCVTKVALNVSCANLLDKDIGSKSDPLCVLFLNTSGQQWYEVERTERIKNCLNPQFSKTFIIDYYFEVVQKLKFGVYDIDNKTIELSDDDFLGECECTLGQIVSSKKLTRPLVMKTGRPAGKGSITISAEEIKDNRVVLFEMEARKLDNKDLFGKSDPYLEFHKQTSDGNWLMVHRTEVVKNNLNPVWRPFKISLNSLCYGDMDKTIKVECYDYDNDGSHDLIGTFQTTMTKLKEASRSSPVEFECINEKKRQKKKSYKNSGVISVKQCEITVECTFLDYIMGGCQLNFTVGVDFTGSNGDPRSPDSLHYISPNGVNEYLTALWSVGLVIQDYDADKMFPAFGFGAQIPPQWQVSHEFPMNFNPSNPYCNGIQGIVEAYRSCLPQIKLYGPTNFSPIINHVARFAAAATQQQTASQYFVLLIITDGVITDLDETRQAIVNASRLPMSIIIVGVGGADFSAMEFLDGDGGSLRSPLGEVAIRDIVQFVPFRQFQNAPKEALAQCVLAEIPQQVVGYFNTYKLLPPKNPATKQQKQ

Gene Information

Entrez Gene ID
8895
Gene Name
copine III
Gene Symbol
CPNE3
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 NAS:UniProtKB C cytoplasm
GO:0005829 IDA:UniProtKB C cytosol
GO:0070062 IDA:UniProtKB C extracellular vesicular exosome
GO:0005544 TAS:UniProtKB F calcium-dependent phospholipid binding
GO:0044822 IDA:UniProtKB F poly(A) RNA binding
GO:0004674 IDA:UniProtKB F protein serine/threonine kinase activity
GO:0005215 TAS:ProtInc F transporter activity
GO:0006629 TAS:ProtInc P lipid metabolic process
GO:0006468 IDA:GOC P protein phosphorylation
GO:0016192 TAS:ProtInc P vesicle-mediated transport

Domain Information

InterPro Annotations

Accession Description
IPR000008 C2 domain
IPR010734 Copine
IPR002035 von Willebrand factor, type A

UniProt Annotations

Entry Information

Gene Name
copine III
Protein Entry
CPNE3_HUMAN
UniProt ID
O75131
Species
Human

Comments

Comment Type Description
Caution Was reported to have a protein kinase activity.
Function May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties (By similarity).
Ptm Phosphorylated on serine and threonine residues.
Sequence Caution Sequence=BAA31611.2; Type=Erroneous initiation; Evidence= ;
Similarity Belongs to the copine family.
Similarity Contains 1 VWFA domain.
Similarity Contains 2 C2 domains. {ECO
Tissue Specificity Ubiquitous.

Identical and Related Proteins

Unique RefSeq proteins for LMP000885 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
4503015 RefSeq NP_003900 537 copine-3

Identical Sequences to LMP000885 proteins

Reference Database Accession Length Protein Name
GI:4503015 DBBJ BAG09785.1 537 copine-3, partial [synthetic construct]
GI:4503015 EMBL CAV30739.1 537 unnamed protein product [Homo sapiens]
GI:4503015 GenBank ADT49336.1 537 Sequence 1353 from patent US 7842467
GI:4503015 GenBank ADT49337.1 537 Sequence 1354 from patent US 7842467
GI:4503015 GenBank ADT49338.1 537 Sequence 1355 from patent US 7842467
GI:4503015 RefSeq XP_005251150.1 537 PREDICTED: copine-3 isoform X1 [Homo sapiens]

Related Sequences to LMP000885 proteins

Reference Database Accession Length Protein Name
GI:4503015 DBBJ BAA31611.2 540 KIAA0636 protein, partial [Homo sapiens]
GI:4503015 DBBJ BAF85601.1 537 unnamed protein product [Homo sapiens]
GI:4503015 GenBank AAV38382.1 538 copine III, partial [synthetic construct]
GI:4503015 GenBank AAX42825.1 538 copine III, partial [synthetic construct]
GI:4503015 GenBank JAA21437.1 537 copine III [Pan troglodytes]
GI:4503015 RefSeq XP_008972875.1 537 PREDICTED: copine-3 [Pan paniscus]