Gene/Proteome Database (LMPD)

LMPD ID
LMP000889
Gene ID
12660
Species
Mus musculus (Mouse)
Gene Name
choline kinase alpha
Gene Symbol
Chka
Synonyms
CK; CK/EK-alpha; Chetk-alpha; Chk; ChoK; EK; EtnK-alpha
Alternate Names
choline kinase alpha; ethanolamine kinase; choline/ethanolamine kinase alpha
Chromosome
19
Map Location
19 A|19 3.57 cM
EC Number
2.7.1.32

Proteins

choline kinase alpha isoform 1
Refseq ID NP_038518
Protein GI 70908364
UniProt ID O54804
mRNA ID NM_013490
Length 435
RefSeq Status VALIDATED
MKTKFCTGGEAEPSPLGLLLSCGGNAAPTPGVGQQRDAAGELESKQLGGRTQPLALPPPPPPPLPLPPPPSPPLADEQPEPRTRRRAYLWCKEFLPGAWRGLREDQFHISVIRGGLSNMLFQCSLPDSIASVGDEPRKVLLRLYGAILKMGAEAMVLESVMFAILAERSLGPKLFGIFPQGRLEQFIPSRRLDTEELRLPDISAEIAEKMATFHGMKMPFNKEPKWLFGTMEKYLNQVLRLKFSREARVQQLHKILSYNLPLELENLRSLLQYTRSPVVFCHNDCQEGNILLLEGQENSERRKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYTYEKYPFFRANIQKYPSRKQQLHFISSYLTTFQNDFESLSSEEQFATKEDMLLEVNRFALASHFLWGLWSIVQAKISSIEFGYMEYAQARFEAYFDQKRKLGV
choline kinase alpha isoform 3
Refseq ID NP_001258425
Protein GI 407970974
UniProt ID O54804
mRNA ID NM_001271496
Length 453
RefSeq Status VALIDATED
MKTKFCTGGEAEPSPLGLLLSCGGNAAPTPGVGQQRDAAGELESKQLGGRTQPLALPPPPPPPLPLPPPPSPPLADEQPEPRTRRRAYLWCKEFLPGAWRGLREDQFHISVIRGGLSNMLFQCSLPDSIASVGDEPRKVLLRLYGAILKMRSCNKEGSEQAQNENEFQGAEAMVLESVMFAILAERSLGPKLFGIFPQGRLEQFIPSRRLDTEELRLPDISAEIAEKMATFHGMKMPFNKEPKWLFGTMEKYLNQVLRLKFSREARVQQLHKILSYNLPLELENLRSLLQYTRSPVVFCHNDCQEGNILLLEGQENSERRKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYTYEKYPFFRANIQKYPSRKQQLHFISSYLTTFQNDFESLSSEEQFATKEDMLLEVNRFALASHFLWGLWSIVQAKISSIEFGYMEYAQARFEAYFDQKRKLGV

Gene Information

Entrez Gene ID
12660
Gene Name
choline kinase alpha
Gene Symbol
Chka
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0033265 IEA:Ensembl F choline binding
GO:0004103 ISS:UniProtKB F choline kinase activity
GO:0004104 IDA:MGI F cholinesterase activity
GO:0008144 ISS:UniProtKB F drug binding
GO:0004305 ISS:UniProtKB F ethanolamine kinase activity
GO:0042803 IPI:MGI F protein homodimerization activity
GO:0006657 IDA:GOC P CDP-choline pathway
GO:0019695 IEA:Ensembl P choline metabolic process
GO:0006656 ISS:UniProtKB P phosphatidylcholine biosynthetic process
GO:0006646 ISS:UniProtKB P phosphatidylethanolamine biosynthetic process

Domain Information

InterPro Annotations

Accession Description
IPR011009 Protein kinase-like domain

UniProt Annotations

Entry Information

Gene Name
choline kinase alpha
Protein Entry
CHKA_MOUSE
UniProt ID
O54804
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=CHETK-alpha2; IsoId=O54804-1; Sequence=Displayed; Name=2; Synonyms=CHETK-alpha1; IsoId=O54804-2; Sequence=VSP_009684;
Catalytic Activity ATP + choline = ADP + phosphocholine.
Catalytic Activity ATP + ethanolamine = ADP + O- phosphoethanolamine.
Disruption Phenotype Death at an early embryonic stage. Embryos die after 3 to 5 days of development. {ECO:0000269|PubMed:18029352}.
Function Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline (By similarity). {ECO:0000250}.
Pathway Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphocholine from choline: step 1/1.
Pathway Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.
Sequence Caution Sequence=AAH56758.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=BAA88154.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAB29191.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=BAC34841.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=BAC35539.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
Similarity Belongs to the choline/ethanolamine kinase family. {ECO:0000305}.
Subcellular Location Cytoplasm.
Subunit Homodimer, and heterodimer with CHKB. {ECO:0000269|PubMed:16490392}.
Tissue Specificity Expressed ubiquitously with the highest level in testis.

Identical and Related Proteins

Unique RefSeq proteins for LMP000889 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
70908364 RefSeq NP_038518 435 choline kinase alpha isoform 1
407970974 RefSeq NP_001258425 453 choline kinase alpha isoform 3

Identical Sequences to LMP000889 proteins

Reference Database Accession Length Protein Name
GI:407970974 GenBank EDL32956.1 453 choline kinase alpha, isoform CRA_a [Mus musculus]
GI:70908364 GenBank EDL32961.1 435 choline kinase alpha, isoform CRA_f [Mus musculus]
GI:407970974 SwissProt O54804.3 453 RecName: Full=Choline kinase alpha; Short=CK; AltName: Full=CHETK-alpha; AltName: Full=Ethanolamine kinase; Short=EK [Mus musculus]

Related Sequences to LMP000889 proteins

Reference Database Accession Length Protein Name
GI:70908364 DBBJ BAA24898.1 435 choline kinase [Mus musculus]
GI:70908364 DBBJ BAA88153.1 435 choline/ethanolamine kinase-alpha [Mus musculus]
GI:70908364 DBBJ BAE38793.1 435 unnamed protein product [Mus musculus]
GI:70908364 GenBank EDL32956.1 453 choline kinase alpha, isoform CRA_a [Mus musculus]
GI:407970974 GenBank EDM12304.1 453 choline kinase alpha, isoform CRA_c [Rattus norvegicus]
GI:70908364 RefSeq NP_001258425.1 453 choline kinase alpha isoform 3 [Mus musculus]
GI:407970974 RefSeq XP_005351682.1 453 PREDICTED: choline kinase alpha isoform X1 [Microtus ochrogaster]
GI:407970974 RefSeq XP_006230769.1 463 PREDICTED: choline kinase alpha isoform X1 [Rattus norvegicus]
GI:407970974 RefSeq XP_006230770.1 453 PREDICTED: choline kinase alpha isoform X2 [Rattus norvegicus]
GI:407970974 RefSeq XP_006531709.1 463 PREDICTED: choline kinase alpha isoform X1 [Mus musculus]
GI:407970974 SwissProt Q01134.2 453 RecName: Full=Choline kinase alpha; Short=CK; AltName: Full=CHETK-alpha; AltName: Full=Ethanolamine kinase; Short=EK [Rattus norvegicus]
GI:70908364 SwissProt O54804.3 453 RecName: Full=Choline kinase alpha; Short=CK; AltName: Full=CHETK-alpha; AltName: Full=Ethanolamine kinase; Short=EK [Mus musculus]