Gene/Proteome Database (LMPD)
LMPD ID
LMP000912
Gene ID
Species
Homo sapiens (Human)
Gene Name
fatty acid binding protein 2, intestinal
Gene Symbol
Synonyms
FABPI; I-FABP
Alternate Names
fatty acid-binding protein, intestinal; fatty acid-binding protein 2; intestinal-type fatty acid-binding protein
Chromosome
4
Map Location
4q28-q31
Summary
The intracellular fatty acid-binding proteins (FABPs) belong to a multigene family with nearly twenty identified members. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Intestinal fatty acid-binding protein 2 gene contains four exons and is an abundant cytosolic protein in small intestine epithelial cells. This gene has a polymorphism at codon 54 that identified an alanine-encoding allele and a threonine-encoding allele. Thr-54 protein is associated with increased fat oxidation and insulin resistance. [provided by RefSeq, Jul 2008]
Orthologs
Proteins
Gene Information
Entrez Gene ID
Gene Name
fatty acid binding protein 2, intestinal
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005737 | IEA:UniProtKB-KW | C | cytoplasm |
| GO:0005504 | TAS:ProtInc | F | fatty acid binding |
| GO:0005215 | IEA:InterPro | F | transporter activity |
| GO:0007586 | TAS:ProtInc | P | digestion |
KEGG Pathway Links
Domain Information
UniProt Annotations
Entry Information
Gene Name
fatty acid binding protein 2, intestinal
Protein Entry
FABPI_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Domain | Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior. |
| Function | FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long- chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor. |
| Induction | By EGF. |
| Similarity | Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. |
| Subcellular Location | Cytoplasm. |
| Tissue Specificity | Expressed in the small intestine and at much lower levels in the large intestine. Highest expression levels in the jejunum. |
Identical and Related Proteins
Unique RefSeq proteins for LMP000912 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 194097325 | RefSeq | NP_000125 | 132 | fatty acid-binding protein, intestinal |
Identical Sequences to LMP000912 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:194097325 | GenBank | AAI11792.1 | 132 | Fatty acid binding protein 2, intestinal [Homo sapiens] |
Related Sequences to LMP000912 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:194097325 | GenBank | AAH69637.1 | 132 | Fatty acid binding protein 2, intestinal [Homo sapiens] |
| GI:194097325 | GenBank | EAW73666.1 | 132 | fatty acid binding protein 2, intestinal [Homo sapiens] |
| GI:194097325 | GenBank | ABY15170.1 | 132 | Sequence 545 from patent US 7306913 |
| GI:194097325 | GenBank | ADQ32865.1 | 132 | fatty acid binding protein 2, intestinal, partial [synthetic construct] |
| GI:194097325 | GenBank | ADS31041.1 | 132 | Sequence 1573 from patent US 7781168 |
| GI:194097325 | GenBank | AIC54369.1 | 132 | FABP2, partial [synthetic construct] |