Gene/Proteome Database (LMPD)

LMPD ID
LMP000929
Gene ID
66350
Species
Mus musculus (Mouse)
Gene Name
phospholipase A2, group XIIA
Gene Symbol
Pla2g12a
Synonyms
2310004B05Rik; GXII; GXII-1; GXII-1-PLA2; Pla2g12; Rossy; mGXII-1
Alternate Names
group XIIA secretory phospholipase A2; group XII-1 phospholipase A2; group XIIA secreted phospholipase A2; phosphatidylcholine 2-acylhydrolase 12A
Chromosome
3
Map Location
3 H1|3
EC Number
3.1.1.4

Proteins

group XIIA secretory phospholipase A2 isoform 1 precursor
Refseq ID NP_075685
Protein GI 170295846
UniProt ID Q9EPR2
mRNA ID NM_023196
Length 192
RefSeq Status VALIDATED
MVTPRPAPARSPALLLLLLLATARGQEQDQTTDWRATLKTIRNGIHKIDTYLNAALDLLGGEDGLCQYKCSDGSKPVPRYGYKPSPPNGCGSPLFGVHLNIGIPSLTKCCNQHDRCYETCGKSKNDCDEEFQYCLSKICRDVQKTLGLSQNVQACETTVELLFDSVIHLGCKPYLDSQRAACWCRYEEKTDL
group XIIA secretory phospholipase A2 isoform 2
Refseq ID NP_904359
Protein GI 34556197
UniProt ID Q9EPR2
mRNA ID NM_183423
Length 153
RefSeq Status VALIDATED
MKDYHSGPGKYWEPFAFPVGCSGTEEEEGLRIGRSKPVPRYGYKPSPPNGCGSPLFGVHLNIGIPSLTKCCNQHDRCYETCGKSKNDCDEEFQYCLSKICRDVQKTLGLSQNVQACETTVELLFDSVIHLGCKPYLDSQRAACWCRYEEKTDL
sig_peptide: 1..25 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2599 peptide sequence: MVTPRPAPARSPALLLLLLLATARG sig_peptide: 1..25 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2599 peptide sequence: MVTPRPAPARSPALLLLLLLATARG mat_peptide: 26..192 product: Group XIIA secretory phospholipase A2 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q9EPR2.2) calculated_mol_wt: 18738 peptide sequence: QEQDQTTDWRATLKTIRNGIHKIDTYLNAALDLLGGEDGLCQYKCSDGSKPVPRYGYKPSPPNGCGSPLFGVHLNIGIPSLTKCCNQHDRCYETCGKSKNDCDEEFQYCLSKICRDVQKTLGLSQNVQACETTVELLFDSVIHLGCKPYLDSQRAACWCRYEEKTDL

Gene Information

Entrez Gene ID
66350
Gene Name
phospholipase A2, group XIIA
Gene Symbol
Pla2g12a
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IDA:MGI C endoplasmic reticulum
GO:0005576 IEA:UniProtKB-KW C extracellular region
GO:0005794 IDA:MGI C Golgi apparatus
GO:0005622 IDA:MGI C intracellular
GO:0005509 IEA:InterPro F calcium ion binding
GO:0004623 IDA:MGI F phospholipase A2 activity
GO:0016042 IC:MGI P lipid catabolic process
GO:0006644 IEA:InterPro P phospholipid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu04975 Fat digestion and absorption
mmu04972 Pancreatic secretion
mmu04014 Ras signaling pathway
mmu04270 Vascular smooth muscle contraction

Domain Information

InterPro Annotations

Accession Description
IPR013090 Phospholipase A2, active site
IPR016090 Phospholipase A2 domain
IPR010711 Phospholipase A2, group XII secretory

UniProt Annotations

Entry Information

Gene Name
phospholipase A2, group XIIA
Protein Entry
PG12A_MOUSE
UniProt ID
Q9EPR2
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9EPR2-1; Sequence=Displayed; Name=2; IsoId=Q9EPR2-2; Sequence=VSP_004509;
Catalytic Activity Phosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate. {ECO:0000255|PROSITE- ProRule:PRU10035}.
Cofactor Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250}; Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000250};
Function PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl- phosphatidylcholine or -phosphatidylethanolamine (By similarity). {ECO:0000250}.
Similarity Belongs to the phospholipase A2 family. {ECO:0000305}.
Subcellular Location Secreted. Cytoplasm {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000929 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
170295846 RefSeq NP_075685 192 group XIIA secretory phospholipase A2 isoform 1 precursor
34556197 RefSeq NP_904359 153 group XIIA secretory phospholipase A2 isoform 2

Identical Sequences to LMP000929 proteins

Reference Database Accession Length Protein Name
GI:170295846 DBBJ BAB26641.1 192 unnamed protein product [Mus musculus]
GI:170295846 DBBJ BAB26747.1 192 unnamed protein product [Mus musculus]
GI:170295846 DBBJ BAE37460.1 192 unnamed protein product [Mus musculus]
GI:34556197 GenBank AAG23337.1 153 group XII-2 phospholipase A2 [Mus musculus]
GI:170295846 GenBank AAH51117.1 192 Pla2g12a protein [Mus musculus]
GI:34556197 GenBank EDL12226.1 153 phospholipase A2, group XIIA, isoform CRA_a [Mus musculus]
GI:170295846 GenBank AEU43342.1 192 Sequence 91 from patent US 8052970
GI:170295846 SwissProt Q9EPR2.2 192 RecName: Full=Group XIIA secretory phospholipase A2; Short=GXII sPLA2; Short=sPLA2-XII; AltName: Full=Phosphatidylcholine 2-acylhydrolase 12A; Flags: Precursor [Mus musculus]

Related Sequences to LMP000929 proteins

Reference Database Accession Length Protein Name
GI:170295846 DBBJ BAB26094.1 192 unnamed protein product [Mus musculus]
GI:34556197 DBBJ BAB26747.1 192 unnamed protein product [Mus musculus]
GI:170295846 DBBJ BAC25368.1 205 unnamed protein product, partial [Mus musculus]
GI:34556197 DBBJ BAC25368.1 205 unnamed protein product, partial [Mus musculus]
GI:34556197 DBBJ BAE37460.1 192 unnamed protein product [Mus musculus]
GI:170295846 GenBank AAG23336.1 192 group XII-1 phospholipase A2 [Mus musculus]
GI:34556197 GenBank AAG23336.1 192 group XII-1 phospholipase A2 [Mus musculus]
GI:170295846 GenBank AAH26812.1 192 Phospholipase A2, group XIIA [Mus musculus]
GI:34556197 GenBank AAH26812.1 192 Phospholipase A2, group XIIA [Mus musculus]
GI:170295846 GenBank EDL12227.1 187 phospholipase A2, group XIIA, isoform CRA_b, partial [Mus musculus]
GI:170295846 RefSeq XP_005357331.1 196 PREDICTED: group XIIA secretory phospholipase A2 [Microtus ochrogaster]
GI:34556197 RefSeq XP_006232067.2 159 PREDICTED: group XIIA secretory phospholipase A2 isoform X2 [Rattus norvegicus]