Gene/Proteome Database (LMPD)

LMPD ID
LMP000936
Gene ID
23236
Species
Homo sapiens (Human)
Gene Name
phospholipase C, beta 1 (phosphoinositide-specific)
Gene Symbol
PLCB1
Synonyms
EIEE12; PI-PLC; PLC-154; PLC-I; PLC154; PLCB1A; PLCB1B
Alternate Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1; PLC-beta-1; phospholipase C-I; phosphoinositidase C; inositoltrisphosphohydrolase; triphosphoinositide phosphodiesterase; monophosphatidylinositol phosphodiesterase; 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate
Chromosome
20
Map Location
20p12
EC Number
3.1.4.11
Summary
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for PLCB1

Proteins

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform a
Refseq ID NP_056007
Protein GI 12083581
UniProt ID Q9NQ66
mRNA ID NM_015192
Length 1216
RefSeq Status REVIEWED
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKETELLDLSLVKDARCGRHAKAPKDPKLRELLDVGNIGRLEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSADRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEMSNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFKKVVLPTLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNERNQPLTLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKKEADPGETPSEAPSEARTTPAENGVNHTTTLTPKPPSQALHSQPAPGSVKAPAKTEDLIQSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLRRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKPKLQVELEQEYQDKFKRLPLEILEFVQEAMKGKISEDSNHGSAPLSLSSDPGKVNHKTPSSEELGGDIPGKEFDTPL
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform b
Refseq ID NP_877398
Protein GI 33356544
UniProt ID Q9NQ66
mRNA ID NM_182734
Length 1173
RefSeq Status REVIEWED
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKETELLDLSLVKDARCGRHAKAPKDPKLRELLDVGNIGRLEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSADRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEMSNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFKKVVLPTLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNERNQPLTLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKKEADPGETPSEAPSEARTTPAENGVNHTTTLTPKPPSQALHSQPAPGSVKAPAKTEDLIQSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLRRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKPKGEGSSSFLSETCHEDPSVSPNFTPPNPQALKW

Gene Information

Entrez Gene ID
23236
Gene Name
phospholipase C, beta 1 (phosphoinositide-specific)
Gene Symbol
PLCB1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:UniProtKB C cytoplasm
GO:0005829 TAS:Reactome C cytosol
GO:0070062 IDA:UniProt C extracellular vesicular exosome
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0000790 ISS:BHF-UCL C nuclear chromatin
GO:0016607 IDA:BHF-UCL C nuclear speck
GO:0005634 NAS:UniProtKB C nucleus
GO:0005509 IEA:InterPro F calcium ion binding
GO:0005516 IPI:BHF-UCL F calmodulin binding
GO:0019899 IPI:UniProtKB F enzyme binding
GO:0005096 IDA:BHF-UCL F GTPase activator activity
GO:0005546 IDA:BHF-UCL F phosphatidylinositol-4,5-bisphosphate binding
GO:0004435 NAS:UniProtKB F phosphatidylinositol phospholipase C activity
GO:0042803 ISS:BHF-UCL F protein homodimerization activity
GO:0004871 IEA:UniProtKB-KW F signal transducer activity
GO:0060466 ISS:BHF-UCL P activation of meiosis involved in egg activation
GO:0021987 ISS:BHF-UCL P cerebral cortex development
GO:0045444 IEA:Ensembl P fat cell differentiation
GO:0000086 ISS:BHF-UCL P G2/M transition of mitotic cell cycle
GO:0007215 ISS:BHF-UCL P glutamate receptor signaling pathway
GO:0007213 ISS:BHF-UCL P G-protein coupled acetylcholine receptor signaling pathway
GO:0043647 TAS:Reactome P inositol phosphate metabolic process
GO:0048009 ISS:BHF-UCL P insulin-like growth factor receptor signaling pathway
GO:0035722 IDA:BHF-UCL P interleukin-12-mediated signaling pathway
GO:0035723 IDA:BHF-UCL P interleukin-15-mediated signaling pathway
GO:0070498 IDA:BHF-UCL P interleukin-1-mediated signaling pathway
GO:0035556 IEA:InterPro P intracellular signal transduction
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process
GO:0007613 ISS:BHF-UCL P memory
GO:2000438 ISS:BHF-UCL P negative regulation of monocyte extravasation
GO:0045892 ISS:BHF-UCL P negative regulation of transcription, DNA-templated
GO:0046488 ISS:BHF-UCL P phosphatidylinositol metabolic process
GO:2000344 ISS:BHF-UCL P positive regulation of acrosome reaction
GO:2000560 ISS:BHF-UCL P positive regulation of CD24 biosynthetic process
GO:0048639 ISS:BHF-UCL P positive regulation of developmental growth
GO:0040019 ISS:BHF-UCL P positive regulation of embryonic development
GO:1900087 ISS:BHF-UCL P positive regulation of G1/S transition of mitotic cell cycle
GO:0043547 IDA:GOC P positive regulation of GTPase activity
GO:0032735 ISS:BHF-UCL P positive regulation of interleukin-12 production
GO:0046330 IDA:BHF-UCL P positive regulation of JNK cascade
GO:0045663 ISS:BHF-UCL P positive regulation of myoblast differentiation
GO:0045893 ISS:BHF-UCL P positive regulation of transcription, DNA-templated
GO:0080154 ISS:BHF-UCL P regulation of fertilization
GO:0008277 ISS:BHF-UCL P regulation of G-protein coupled receptor protein signaling pathway
GO:0007165 NAS:UniProtKB P signal transduction
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0007268 TAS:Reactome P synaptic transmission

KEGG Pathway Links

KEGG Pathway ID Description
hsa04022 cGMP-PKG signaling pathway
hsa04750 Inflammatory mediator regulation of TRP channels
hsa04921 Oxytocin signaling pathway
hsa04611 Platelet activation

Domain Information

InterPro Annotations

Accession Description
IPR028400 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
IPR000008 C2 domain
IPR011992 EF-hand domain pair
IPR016280 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta
IPR001192 Phosphoinositide phospholipase C family
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
IPR014815 PLC-beta, C-terminal
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain

UniProt Annotations

Entry Information

Gene Name
phospholipase C, beta 1 (phosphoinositide-specific)
Protein Entry
PLCB1_HUMAN
UniProt ID
Q9NQ66
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=A; IsoId=Q9NQ66-1; Sequence=Displayed; Name=B; IsoId=Q9NQ66-2; Sequence=VSP_004718;
Catalytic Activity 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
Cofactor Name=Ca(2+); Xref=ChEBI
Disease Epileptic encephalopathy, early infantile, 12 (EIEE12) [MIM
Function The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
Miscellaneous The receptor-mediated activation of PLC-beta-1 is mediated by two G-protein alpha subunits, alpha-Q and alpha-11.
Sequence Caution Sequence=BAA25507.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence= ; Sequence=BAB14641.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ;
Similarity Contains 1 C2 domain. {ECO
Similarity Contains 1 PI-PLC X-box domain. {ECO
Similarity Contains 1 PI-PLC Y-box domain. {ECO
Subcellular Location Nucleus membrane . Cytoplasm . Note=Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes.
Subunit Interacts with DGKQ.
Web Resource Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/PLCB1ID41742ch20p12.html";

Identical and Related Proteins

Unique RefSeq proteins for LMP000936 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
12083581 RefSeq NP_056007 1216 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform a
33356544 RefSeq NP_877398 1173 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform b

Identical Sequences to LMP000936 proteins

Reference Database Accession Length Protein Name
GI:33356544 GenBank JAA27077.1 1173 phospholipase C, beta 1 (phosphoinositide-specific) [Pan troglodytes]
GI:33356544 GenBank JAA41313.1 1173 phospholipase C, beta 1 (phosphoinositide-specific) [Pan troglodytes]
GI:12083581 GenBank JAA41314.1 1216 phospholipase C, beta 1 (phosphoinositide-specific) [Pan troglodytes]
GI:33356544 GenBank JAA41315.1 1173 phospholipase C, beta 1 (phosphoinositide-specific) [Pan troglodytes]
GI:12083581 GenBank AGX54771.1 1216 Sequence 9898 from patent US 8541208
GI:12083581 GenBank AGX64211.1 1216 Sequence 28532 from patent US 8541208
GI:12083581 GenBank AHD69606.1 1216 Sequence 620 from patent US 8586006
GI:33356544 GenBank AHD69607.1 1173 Sequence 621 from patent US 8586006
GI:12083581 GenBank AIC56028.1 1216 PLCB1, partial [synthetic construct]
GI:33356544 GenBank AIC63332.1 1173 PLCB1, partial [synthetic construct]
GI:33356544 RefSeq XP_006723618.1 1173 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X2 [Homo sapiens]
GI:12083581 RefSeq XP_009435050.1 1216 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [Pan troglodytes]

Related Sequences to LMP000936 proteins

Reference Database Accession Length Protein Name
GI:12083581 DBBJ BAA25507.3 1218 KIAA0581 protein, partial [Homo sapiens]
GI:33356544 EMBL CAB98143.1 1173 phospholipase C-beta-1b [Homo sapiens]
GI:12083581 GenBank JAB15393.1 1216 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform a [Callithrix jacchus]
GI:33356544 GenBank JAB15394.1 1173 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform b [Callithrix jacchus]
GI:12083581 GenBank JAB31314.1 1216 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform a [Callithrix jacchus]
GI:33356544 GenBank JAB31315.1 1173 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform b [Callithrix jacchus]
GI:12083581 GenBank JAB45222.1 1216 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform a [Callithrix jacchus]
GI:33356544 GenBank JAB45223.1 1173 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform b [Callithrix jacchus]
GI:12083581 RefSeq XP_003252637.1 1216 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform 1 [Nomascus leucogenys]
GI:33356544 RefSeq XP_003252638.1 1173 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform 2 [Nomascus leucogenys]
GI:12083581 RefSeq XP_003933260.1 1216 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X2 [Saimiri boliviensis boliviensis]
GI:33356544 RefSeq XP_003933261.1 1173 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X4 [Saimiri boliviensis boliviensis]