Gene/Proteome Database (LMPD)

LMPD ID
LMP000938
Gene ID
22260
Species
Mus musculus (Mouse)
Gene Name
nuclear receptor subfamily 1, group H, member 2
Gene Symbol
Nr1h2
Synonyms
AI194859; LXR; LXRB; LXRbeta; NER1; OR-1; RIP15; UR; Unr; Unr2
Alternate Names
oxysterols receptor LXR-beta; LXR beta; liver X receptor beta; ubiquitously-expressed nuclear receptor 2; retinoid X receptor-interacting protein No.15
Chromosome
7
Map Location
7 B4|7

Proteins

oxysterols receptor LXR-beta isoform a
Refseq ID NP_001272446
Protein GI 550822384
UniProt ID Q60644
mRNA ID NM_001285517
Length 446
RefSeq Status VALIDATED
MSSPTSSLDTPVPGNGSPQPSTSATSPTIKEEGQETDPPPGSEGSSSAYIVVILEPEDEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVHGGAGRYACRGSGTCQMDAFMRRKCQLCRLRKCKEAGMREQCVLSEEQIRKKRIQKQQQQQPPPPSEPAASSSGRPAASPGTSEASSQGSGEGEGIQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPSRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
oxysterols receptor LXR-beta isoform a
Refseq ID NP_033499
Protein GI 6678507
UniProt ID Q60644
mRNA ID NM_009473
Length 446
RefSeq Status VALIDATED
Protein sequence is identical to GI:550822384 (mRNA isoform)
oxysterols receptor LXR-beta isoform b
Refseq ID NP_001272447
Protein GI 550821788
UniProt ID Q60644
mRNA ID NM_001285518
Length 443
RefSeq Status VALIDATED
MSSPTSSLDTPVPGNGSPQPSTSATSPTIKEEGQETDPPPGSEGSSSAYIVEPEDEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVHGGAGRYACRGSGTCQMDAFMRRKCQLCRLRKCKEAGMREQCVLSEEQIRKKRIQKQQQQQPPPPSEPAASSSGRPAASPGTSEASSQGSGEGEGIQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPSRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
oxysterols receptor LXR-beta isoform b
Refseq ID NP_001272448
Protein GI 550822261
UniProt ID Q60644
mRNA ID NM_001285519
Length 443
RefSeq Status VALIDATED
Protein sequence is identical to GI:550821788 (mRNA isoform)

Gene Information

Entrez Gene ID
22260
Gene Name
nuclear receptor subfamily 1, group H, member 2
Gene Symbol
Nr1h2
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005634 IDA:BHF-UCL C nucleus
GO:0003677 IDA:MGI F DNA binding
GO:0004879 IDA:MGI F ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0046965 IDA:MGI F retinoid X receptor binding
GO:0043565 IEA:InterPro F sequence-specific DNA binding
GO:0003700 IDA:MGI F sequence-specific DNA binding transcription factor activity
GO:0003707 IEA:InterPro F steroid hormone receptor activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0044255 IDA:MGI P cellular lipid metabolic process
GO:0042632 IDA:BHF-UCL P cholesterol homeostasis
GO:0030522 IDA:GOC P intracellular receptor signaling pathway
GO:0055088 IMP:BHF-UCL P lipid homeostasis
GO:0045861 IMP:BHF-UCL P negative regulation of proteolysis
GO:0000122 IMP:BHF-UCL P negative regulation of transcription from RNA polymerase II promoter
GO:0010875 IDA:BHF-UCL P positive regulation of cholesterol efflux
GO:0090108 IDA:BHF-UCL P positive regulation of high-density lipoprotein particle assembly
GO:0010884 IMP:BHF-UCL P positive regulation of lipid storage
GO:0090187 IMP:BHF-UCL P positive regulation of pancreatic juice secretion
GO:0090340 IMP:BHF-UCL P positive regulation of secretion of lysosomal enzymes
GO:0045944 IDA:BHF-UCL P positive regulation of transcription from RNA polymerase II promoter
GO:2000188 IMP:UniProtKB P regulation of cholesterol homeostasis
GO:0006355 IDA:MGI P regulation of transcription, DNA-templated
GO:0006357 IGI:MGI P regulation of transcription from RNA polymerase II promoter

REACTOME Pathway Links

REACTOME Pathway ID Description
5892840 Gene Expression
5893343 Generic Transcription Pathway
5893658 Nuclear Receptor transcription pathway

Domain Information

InterPro Annotations

Accession Description
IPR023257 Liver X receptor
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001723 Steroid hormone receptor
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
nuclear receptor subfamily 1, group H, member 2
Protein Entry
NR1H2_MOUSE
UniProt ID
Q60644
Species
Mouse

Comments

Comment Type Description
Function Nuclear receptor. Binds preferentially to double- stranded oligonucleotide direct repeats having the consensus half- site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism. {ECO:0000269|PubMed:18055760, ECO:0000269|PubMed:19520913, ECO:0000269|PubMed:20427281}.
Interaction Q96EB6:SIRT1 (xeno); NbExp=2; IntAct=EBI-5276809, EBI-1802965;
Similarity Belongs to the nuclear hormone receptor family. NR1 subfamily. {ECO:0000305}.
Similarity Contains 1 nuclear receptor DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00407}.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407}.
Subunit Forms a heterodimer with RXR.
Tissue Specificity Ubiquitous.

Identical and Related Proteins

Unique RefSeq proteins for LMP000938 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
550822384 RefSeq NP_001272446 446 oxysterols receptor LXR-beta isoform a
550821788 RefSeq NP_001272447 443 oxysterols receptor LXR-beta isoform b

Identical Sequences to LMP000938 proteins

Reference Database Accession Length Protein Name
GI:550821788 DBBJ BAC36906.1 443 unnamed protein product [Mus musculus]
GI:550821788 DBBJ BAE33850.1 443 unnamed protein product [Mus musculus]
GI:550822384 GenBank AAH66025.1 446 Nuclear receptor subfamily 1, group H, member 2 [Mus musculus]
GI:550822384 GenBank ACN04133.1 446 Sequence 10 from patent US 7482366
GI:550822384 GenBank AEP73957.1 446 Sequence 10 from patent US 8013001
GI:550822384 RefSeq NP_033499.1 446 oxysterols receptor LXR-beta isoform a [Mus musculus]
GI:550821788 RefSeq NP_001272448.1 443 oxysterols receptor LXR-beta isoform b [Mus musculus]
GI:550822384 RefSeq XP_006540867.1 446 PREDICTED: oxysterols receptor LXR-beta isoform X1 [Mus musculus]
GI:550822384 SwissProt Q60644.1 446 RecName: Full=Oxysterols receptor LXR-beta; AltName: Full=Liver X receptor beta; AltName: Full=Nuclear receptor subfamily 1 group H member 2; AltName: Full=Retinoid X receptor-interacting protein No.15; AltName: Full=Ubiquitously-expressed nuclear receptor [Mus musculus]

Related Sequences to LMP000938 proteins

Reference Database Accession Length Protein Name
GI:550821788 DBBJ BAJ07607.1 443 liver X receptor beta [Oryctolagus cuniculus]
GI:550822384 GenBank AAA69522.1 446 orphan nuclear receptor OR-1 [Rattus norvegicus]
GI:550822384 GenBank AAR56782.1 446 Sequence 2 from patent US 6617120
GI:550822384 GenBank ABJ48465.1 446 Sequence 3 from patent US 7115711
GI:550821788 GenBank EDL22735.1 445 nuclear receptor subfamily 1, group H, member 2, isoform CRA_a, partial [Mus musculus]
GI:550822384 GenBank EDL22736.1 448 nuclear receptor subfamily 1, group H, member 2, isoform CRA_b, partial [Mus musculus]
GI:550822384 GenBank EDM07472.1 446 nuclear receptor subfamily 1, group H, member 2, isoform CRA_a [Rattus norvegicus]
GI:550821788 GenBank ACN04133.1 446 Sequence 10 from patent US 7482366
GI:550821788 RefSeq NP_001171965.1 443 oxysterols receptor LXR-beta [Oryctolagus cuniculus]
GI:550821788 RefSeq NP_001272446.1 446 oxysterols receptor LXR-beta isoform a [Mus musculus]
GI:550821788 RefSeq XP_006540867.1 446 PREDICTED: oxysterols receptor LXR-beta isoform X1 [Mus musculus]
GI:550822384 SwissProt Q62755.1 446 RecName: Full=Oxysterols receptor LXR-beta; AltName: Full=Liver X receptor beta; AltName: Full=Nuclear receptor subfamily 1 group H member 2; AltName: Full=Orphan nuclear receptor OR-1; AltName: Full=Ubiquitously-expressed nuclear receptor; Short=UR [Rattus norvegicus]