Gene/Proteome Database (LMPD)

LMPD ID
LMP000938
Gene ID
22260
Species
Mus musculus (Mouse)
Gene Name
nuclear receptor subfamily 1, group H, member 2
Gene Symbol
Nr1h2
Synonyms
AI194859; LXR; LXRB; LXRbeta; NER1; OR-1; RIP15; UR; Unr; Unr2
Alternate Names
oxysterols receptor LXR-beta; LXR beta; liver X receptor beta; ubiquitously-expressed nuclear receptor 2; retinoid X receptor-interacting protein No.15
Chromosome
7
Map Location
7 B4|7

Proteins

oxysterols receptor LXR-beta isoform a
Refseq ID NP_001272446
Protein GI 550822384
UniProt ID Q60644
mRNA ID NM_001285517
Length 446
RefSeq Status VALIDATED
MSSPTSSLDTPVPGNGSPQPSTSATSPTIKEEGQETDPPPGSEGSSSAYIVVILEPEDEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVHGGAGRYACRGSGTCQMDAFMRRKCQLCRLRKCKEAGMREQCVLSEEQIRKKRIQKQQQQQPPPPSEPAASSSGRPAASPGTSEASSQGSGEGEGIQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPSRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
oxysterols receptor LXR-beta isoform a
Refseq ID NP_033499
Protein GI 6678507
UniProt ID Q60644
mRNA ID NM_009473
Length 446
RefSeq Status VALIDATED
Protein sequence is identical to GI:550822384 (mRNA isoform)
oxysterols receptor LXR-beta isoform b
Refseq ID NP_001272447
Protein GI 550821788
UniProt ID Q60644
mRNA ID NM_001285518
Length 443
RefSeq Status VALIDATED
MSSPTSSLDTPVPGNGSPQPSTSATSPTIKEEGQETDPPPGSEGSSSAYIVEPEDEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVHGGAGRYACRGSGTCQMDAFMRRKCQLCRLRKCKEAGMREQCVLSEEQIRKKRIQKQQQQQPPPPSEPAASSSGRPAASPGTSEASSQGSGEGEGIQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPSRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
oxysterols receptor LXR-beta isoform b
Refseq ID NP_001272448
Protein GI 550822261
UniProt ID Q60644
mRNA ID NM_001285519
Length 443
RefSeq Status VALIDATED
Protein sequence is identical to GI:550821788 (mRNA isoform)

Gene Information

Entrez Gene ID
22260
Gene Name
nuclear receptor subfamily 1, group H, member 2
Gene Symbol
Nr1h2
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005634 IDA:BHF-UCL C nucleus
GO:0003677 IDA:MGI F DNA binding
GO:0004879 IDA:MGI F ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0046965 IDA:MGI F retinoid X receptor binding
GO:0043565 IEA:InterPro F sequence-specific DNA binding
GO:0003700 IDA:MGI F sequence-specific DNA binding transcription factor activity
GO:0003707 IEA:InterPro F steroid hormone receptor activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0044255 IDA:MGI P cellular lipid metabolic process
GO:0042632 IDA:BHF-UCL P cholesterol homeostasis
GO:0030522 IDA:GOC P intracellular receptor signaling pathway
GO:0055088 IMP:BHF-UCL P lipid homeostasis
GO:0045861 IMP:BHF-UCL P negative regulation of proteolysis
GO:0000122 IMP:BHF-UCL P negative regulation of transcription from RNA polymerase II promoter
GO:0010875 IDA:BHF-UCL P positive regulation of cholesterol efflux
GO:0090108 IDA:BHF-UCL P positive regulation of high-density lipoprotein particle assembly
GO:0010884 IMP:BHF-UCL P positive regulation of lipid storage
GO:0090187 IMP:BHF-UCL P positive regulation of pancreatic juice secretion
GO:0090340 IMP:BHF-UCL P positive regulation of secretion of lysosomal enzymes
GO:0045944 IDA:BHF-UCL P positive regulation of transcription from RNA polymerase II promoter
GO:2000188 IMP:UniProtKB P regulation of cholesterol homeostasis
GO:0006357 IGI:MGI P regulation of transcription from RNA polymerase II promoter
GO:0006355 IDA:MGI P regulation of transcription, DNA-templated

REACTOME Pathway Links

REACTOME Pathway ID Description
5892840 Gene Expression
5893343 Generic Transcription Pathway
5893658 Nuclear Receptor transcription pathway

Domain Information

InterPro Annotations

Accession Description
IPR023257 Liver X receptor
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001723 Steroid hormone receptor
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
nuclear receptor subfamily 1, group H, member 2
Protein Entry
NR1H2_MOUSE
UniProt ID
Q60644
Species
Mouse

Comments

Comment Type Description
Function Nuclear receptor. Binds preferentially to double- stranded oligonucleotide direct repeats having the consensus half- site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism. {ECO:0000269|PubMed:18055760, ECO:0000269|PubMed:19520913, ECO:0000269|PubMed:20427281}.
Interaction Q96EB6:SIRT1 (xeno); NbExp=2; IntAct=EBI-5276809, EBI-1802965;
Similarity Belongs to the nuclear hormone receptor family. NR1 subfamily. {ECO:0000305}.
Similarity Contains 1 nuclear receptor DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00407}.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407}.
Subunit Forms a heterodimer with RXR.
Tissue Specificity Ubiquitous.

Identical and Related Proteins

Unique RefSeq proteins for LMP000938 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
550822384 RefSeq NP_001272446 446 oxysterols receptor LXR-beta isoform a
550821788 RefSeq NP_001272447 443 oxysterols receptor LXR-beta isoform b

Identical Sequences to LMP000938 proteins

Reference Database Accession Length Protein Name
GI:550821788 DBBJ BAC36906.1 443 unnamed protein product [Mus musculus]
GI:550821788 DBBJ BAE33850.1 443 unnamed protein product [Mus musculus]
GI:550822384 GenBank AAH66025.1 446 Nuclear receptor subfamily 1, group H, member 2 [Mus musculus]
GI:550822384 GenBank ACN04133.1 446 Sequence 10 from patent US 7482366
GI:550822384 GenBank AEP73957.1 446 Sequence 10 from patent US 8013001
GI:550822384 RefSeq NP_033499.1 446 oxysterols receptor LXR-beta isoform a [Mus musculus]
GI:550821788 RefSeq NP_001272448.1 443 oxysterols receptor LXR-beta isoform b [Mus musculus]
GI:550822384 RefSeq XP_006540867.1 446 PREDICTED: oxysterols receptor LXR-beta isoform X1 [Mus musculus]
GI:550822384 SwissProt Q60644.1 446 RecName: Full=Oxysterols receptor LXR-beta; AltName: Full=Liver X receptor beta; AltName: Full=Nuclear receptor subfamily 1 group H member 2; AltName: Full=Retinoid X receptor-interacting protein No.15; AltName: Full=Ubiquitously-expressed nuclear receptor [Mus musculus]

Related Sequences to LMP000938 proteins

Reference Database Accession Length Protein Name
GI:550821788 DBBJ BAJ07607.1 443 liver X receptor beta [Oryctolagus cuniculus]
GI:550822384 GenBank AAA69522.1 446 orphan nuclear receptor OR-1 [Rattus norvegicus]
GI:550822384 GenBank AAR56782.1 446 Sequence 2 from patent US 6617120
GI:550822384 GenBank ABJ48465.1 446 Sequence 3 from patent US 7115711
GI:550821788 GenBank EDL22735.1 445 nuclear receptor subfamily 1, group H, member 2, isoform CRA_a, partial [Mus musculus]
GI:550822384 GenBank EDL22736.1 448 nuclear receptor subfamily 1, group H, member 2, isoform CRA_b, partial [Mus musculus]
GI:550822384 GenBank EDM07472.1 446 nuclear receptor subfamily 1, group H, member 2, isoform CRA_a [Rattus norvegicus]
GI:550821788 GenBank ACN04133.1 446 Sequence 10 from patent US 7482366
GI:550821788 RefSeq NP_001171965.1 443 oxysterols receptor LXR-beta [Oryctolagus cuniculus]
GI:550821788 RefSeq NP_001272446.1 446 oxysterols receptor LXR-beta isoform a [Mus musculus]
GI:550821788 RefSeq XP_006540867.1 446 PREDICTED: oxysterols receptor LXR-beta isoform X1 [Mus musculus]
GI:550822384 SwissProt Q62755.1 446 RecName: Full=Oxysterols receptor LXR-beta; AltName: Full=Liver X receptor beta; AltName: Full=Nuclear receptor subfamily 1 group H member 2; AltName: Full=Orphan nuclear receptor OR-1; AltName: Full=Ubiquitously-expressed nuclear receptor; Short=UR [Rattus norvegicus]