Gene/Proteome Database (LMPD)

LMPD ID
LMP000943
Gene ID
11982
Species
Mus musculus (Mouse)
Gene Name
ATPase, class V, type 10A
Gene Symbol
Atp10a
Synonyms
Atp10c; pfatp
Alternate Names
probable phospholipid-transporting ATPase VA; ATPase, class 5; ATPase 10A, class V; P-locus fat-associated ATPase; P4-ATPase flippase complex alpha subunit ATP10A
Chromosome
7
Map Location
7 C|7
EC Number
3.6.3.1

Proteins

probable phospholipid-transporting ATPase VA
Refseq ID NP_033858
Protein GI 157951686
UniProt ID O54827
mRNA ID NM_009728
Length 1508
RefSeq Status VALIDATED
MERELPAAEESASSGWRRPRRRRWEGRTRTVRSNLLPPLGTEDSTIGAPKGERLLMRGCIQHLADNRLKTTKYTLLSFLPKNLFEQFHRLANVYFVFIALLNFVPAVNAFQPGLALAPVLFILAVTAIKDLWEDYSRHRSDHEINHLGCLVFSREEKKYVNRYWKEIRVGDFVRLCCNEIIPADILLLSSSDPDGLCHIETANLDGETNLKRRQVVRGFSELVSEFNPLTFTSVIECEKPNNDLSRFRGYIMHSNGEKAGLHKENLLLRGCTIRNTEAVAGIVIYAGHETKALLNNSGPRYKRSQLERQMNCDVLWCVLLLVCISLFSAVGHGLWVRRYQEKKALFDVPESDGSSLSPATAAVYSFFTMIIVLQVLIPISLYVSIEIVKVCQVYFINQDIELYDEETDSQLQCRALNITEDLGQIKYIFSDKTGTLTENKMVFRRCTVSGIEYSHDANAQRLARYQEADSEEEEVVSKVGTISHRGSTGSHQSIWMTHKTQSIKSHRRTGSRAEAKRASMLSKHTAFSSPMEKDITPDPKLLEKVSECDRFLAIARHQEHPLAHLSPELSDVFDFFIALTICNTVVVTSPDQPRQKVRVRFELKSPVKTIEDFLRRFTPSRLASGCSSIGNLSTSKSSHKSGSAFLPSLSQDSMLLGLEEKLGQTAPSIASNGYASQAGQEESWASECTTDQKCPGEQREQQEGELRYEAESPDEAALVYAARAYNCALVDRLHDQVSVELPHLGRLTFELLHTLGFDSIRKRMSVVIRHPLTDEINVYTKGADSVVMDLLLPCSSDDARGRHQKKIRSKTQNYLNLYAVEGLRTLCIAKRVLSKEEYACWLQSHIEAEASVESREELLFQSAVRLETNLHLLGATGIEDRLQEGVPETIAKLRQAGLQIWVLTGDKQETAINIAYACKLLDHGEEVITLNADSQEACAALLDQCLSYVQSRNPRSTLQNSESNLSVGFSFNPVSTSTDASPSPSLVIDGRSLAYALEKSLEDKFLFLAKQCRSVLCCRSTPLQKSMVVKLVRSKLKAMTLAIGDGANDVSMIQVADVGVGISGQEGMQAVMASDFAVPRFRYLERLLIVHGHWCYSRLANMVLYFFYKNTMFVGLLFWFQFYCGFSASAMIDQWYLIFFNLLFSSLPQLVTGVLDKDVPADMLLREPQLYKSGQNMEEYRPRAFWLNMVDAAFQSLVCFFIPYLAYYDSDVDVFTWGTPVTAIALFTFLLHLGIETKTWTWLNWLACGFSTFLFFSVALIYNTSCATCYPPSNPYWTMQTLLGDPLFYLTCLIAPIAALLPRLFFKALQGSLFPTQLQLGRQLAKKPLNKFSDPKETFAQGQPPGHSETELSERKTMGPFETLPRDCASQASQFTQQLTCSPEASGEPSAVDTNMPLRENTLLEGLGSQASGSSMPRGAISEVCPGDSKRQSTSASQTARLSSLFHLPSFGSLNWISSLSLASGLGSVLQLSGSSLQMDKQDGEFLSNPPQPEQDLHSFQGQVTGYL

Gene Information

Entrez Gene ID
11982
Gene Name
ATPase, class V, type 10A
Gene Symbol
Atp10a
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0019829 IEA:InterPro F cation-transporting ATPase activity
GO:0000287 IEA:InterPro F magnesium ion binding
GO:0004012 IEA:UniProtKB-EC F phospholipid-translocating ATPase activity

REACTOME Pathway Links

REACTOME Pathway ID Description
5893745 Ion channel transport
5893744 Ion transport by P-type ATPases
5892775 Transmembrane transport of small molecules

Domain Information

InterPro Annotations

Accession Description
IPR008250 ATPase_P-typ_transduc_dom_A
IPR001757 Cation_transp_P_typ_ATPase
IPR023214 HAD-like domain
IPR023299 P-type ATPase, cytoplasmic domain N
IPR018303 P-type ATPase, phosphorylation site
IPR006539 P-type ATPase, subfamily IV

UniProt Annotations

Entry Information

Gene Name
ATPase, class V, type 10A
Protein Entry
AT10A_MOUSE
UniProt ID
O54827
Species
Mouse

Comments

Comment Type Description
Catalytic Activity ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).
Function Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (By similarity). {ECO:0000250}.
Similarity Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. {ECO:0000305}.
Subcellular Location Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}. Note=Exit from the endoplasmic reticulum requires the presence of TMEM30A. {ECO:0000250}.
Subunit Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit and an accessory beta subunit. {ECO:0000250}.
Tissue Specificity Found in testis and in white adipose tissue. Also detected in fetal tissues. {ECO:0000269|PubMed:11074018}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000943 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
157951686 RefSeq NP_033858 1508 probable phospholipid-transporting ATPase VA

Identical Sequences to LMP000943 proteins

Reference Database Accession Length Protein Name
GI:157951686 DBBJ BAE21012.1 1508 unnamed protein product [Mus musculus]
GI:157951686 GenBank EDL21857.1 1508 ATPase, class V, type 10A, isoform CRA_a [Mus musculus]
GI:157951686 GenBank AAI38357.1 1508 ATPase, class V, type 10A [Mus musculus]
GI:157951686 GenBank AAI38358.1 1508 ATPase, class V, type 10A [Mus musculus]
GI:157951686 RefSeq XP_006540643.1 1508 PREDICTED: probable phospholipid-transporting ATPase VA isoform X2 [Mus musculus]
GI:157951686 RefSeq XP_006540644.1 1508 PREDICTED: probable phospholipid-transporting ATPase VA isoform X3 [Mus musculus]

Related Sequences to LMP000943 proteins

Reference Database Accession Length Protein Name
GI:157951686 DBBJ BAD32250.1 1521 mKIAA0566 protein, partial [Mus musculus]
GI:157951686 GenBank AAF09447.1 1508 putative E1-E2 ATPase [Mus musculus]
GI:157951686 GenBank ABC16143.1 1508 Sequence 47 from patent US 6972187
GI:157951686 GenBank ABC16163.1 1508 Sequence 85 from patent US 6972187
GI:157951686 GenBank EDL21858.1 1548 ATPase, class V, type 10A, isoform CRA_b, partial [Mus musculus]
GI:157951686 RefSeq XP_006540642.1 1554 PREDICTED: probable phospholipid-transporting ATPase VA isoform X1 [Mus musculus]