Gene/Proteome Database (LMPD)

LMPD ID
LMP000946
Gene ID
66945
Species
Mus musculus (Mouse)
Gene Name
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
Gene Symbol
Sdha
Synonyms
1500032O14Rik; 2310034D06Rik; 4921513A11; C81073; FP; SDH2; SDHF
Alternate Names
succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; flavoprotein subunit of complex II
Chromosome
13
Map Location
13 C1|13
EC Number
1.3.5.1

Proteins

succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor
Refseq ID NP_075770
Protein GI 54607098
UniProt ID Q8K2B3
mRNA ID NM_023281
Length 664
RefSeq Status VALIDATED
MAGVGAVSRLLRGRRLALTGAWPGTLQKQTCGFHFSVGENKKASAKVSDAISTQYPVVDHEFDAVVVGAGGAGLRAAFGLSEAGFNTACLTKLFPTRSHTVAAQGGINAALGNMEEDNWRWHFYDTVKGSDWLGDQDAIHYMTEQAPASVVELENYGMPFSRTEDGKIYQRAFGGQSLKFGKGGQAHRCCCVADRTGHSLLHTLYGRSLRYDTSYFVEYFALDLLMENGECRGVIALCIEDGSIHRIRAKNTVIATGGYGRTYFSCTSAHTSTGDGTAMVTRAGLPCQDLEFVQFHPTGIYGAGCLITEGCRGEGGILINSQGERFMERYAPVAKDLASRDVVSRSMTLEIREGRGCGPEKDHVYLQLHHLPPEQLATRLPGISETAMIFAGVDVTKEPIPVLPTVHYNMGGIPTNYKGQVLKHVNGQDQIVPGLYACGEAACASVHGANRLGANSLLDLVVFGRACALSIAESCRPGDKVPSIKANAGEESVMNLDKLRFADGSIRTSELRLNMQKSMQNHAAVFRVGSVLQEGCEKISQLYGDLKHLKTFDRGMVWNTDLVETLELQNLMLCALQTIYGAEARKESRGAHAREDYKVRVDEYDYSKPIQGQQKKPFGEHWRKHTLSYVDIKTGKVTLEYRPVIDKTLNEADCATVPPAIRSY
transit_peptide: 1..43 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (Q8K2B3.1) calculated_mol_wt: 4571 peptide sequence: MAGVGAVSRLLRGRRLALTGAWPGTLQKQTCGFHFSVGENKKA mat_peptide: 44..664 product: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q8K2B3.1) calculated_mol_wt: 68032 peptide sequence: SAKVSDAISTQYPVVDHEFDAVVVGAGGAGLRAAFGLSEAGFNTACLTKLFPTRSHTVAAQGGINAALGNMEEDNWRWHFYDTVKGSDWLGDQDAIHYMTEQAPASVVELENYGMPFSRTEDGKIYQRAFGGQSLKFGKGGQAHRCCCVADRTGHSLLHTLYGRSLRYDTSYFVEYFALDLLMENGECRGVIALCIEDGSIHRIRAKNTVIATGGYGRTYFSCTSAHTSTGDGTAMVTRAGLPCQDLEFVQFHPTGIYGAGCLITEGCRGEGGILINSQGERFMERYAPVAKDLASRDVVSRSMTLEIREGRGCGPEKDHVYLQLHHLPPEQLATRLPGISETAMIFAGVDVTKEPIPVLPTVHYNMGGIPTNYKGQVLKHVNGQDQIVPGLYACGEAACASVHGANRLGANSLLDLVVFGRACALSIAESCRPGDKVPSIKANAGEESVMNLDKLRFADGSIRTSELRLNMQKSMQNHAAVFRVGSVLQEGCEKISQLYGDLKHLKTFDRGMVWNTDLVETLELQNLMLCALQTIYGAEARKESRGAHAREDYKVRVDEYDYSKPIQGQQKKPFGEHWRKHTLSYVDIKTGKVTLEYRPVIDKTLNEADCATVPPAIRSY

Gene Information

Entrez Gene ID
66945
Gene Name
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
Gene Symbol
Sdha
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005743 ISS:UniProtKB C mitochondrial inner membrane
GO:0005749 ISS:UniProtKB C mitochondrial respiratory chain complex II
GO:0005739 IDA:MGI C mitochondrion
GO:0050660 IEA:InterPro F flavin adenine dinucleotide binding
GO:0008177 IEA:UniProtKB-EC F succinate dehydrogenase (ubiquinone) activity
GO:0007399 IEA:Ensembl P nervous system development
GO:0022904 ISS:UniProtKB P respiratory electron transport chain
GO:0006105 ISS:UniProtKB P succinate metabolic process
GO:0006099 IEA:UniProtKB-UniPathway P tricarboxylic acid cycle

KEGG Pathway Links

KEGG Pathway ID Description
mmu05010 Alzheimer's disease
mmu05016 Huntington's disease
mmu04932 Non-alcoholic fatty liver disease (NAFLD)
mmu05012 Parkinson's disease

Domain Information

InterPro Annotations

Accession Description
IPR003953 FAD binding domain
IPR015939 Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal
IPR003952 Fumarate reductase/succinate dehydrogenase, FAD-binding site
IPR011281 Succinate dehydrogenase, flavoprotein subunit
IPR027477 Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
IPR014006 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

UniProt Annotations

Entry Information

Gene Name
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
Protein Entry
SDHA_MOUSE
UniProt ID
Q8K2B3
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Succinate + a quinone = fumarate + a quinol.
Cofactor Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
Function Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Can act as a tumor suppressor. {ECO:0000250}.
Pathway Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.
Ptm Acetylation of Lys-498 and Lys-538 is observed in liver mitochondria from fasted mice but not from fed mice. Deacetylated by SIRT3. {ECO:0000269|PubMed:21858060, ECO:0000269|PubMed:23576753, ECO:0000269|PubMed:23806337}.
Ptm Phosphorylation at Tyr-215 is important for efficient electron transfer in complex II and the prevention of ROS generation. {ECO:0000250}.
Similarity Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. {ECO:0000305}.
Subcellular Location Mitochondrion inner membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Matrix side {ECO:0000250}.
Subunit Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD. Interacts with SDHAF2/SDH5; interaction is required for FAD attachment (By similarity). Interacts with TRAP1 (By similarity). {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000946 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
54607098 RefSeq NP_075770 664 succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor

Identical Sequences to LMP000946 proteins

Reference Database Accession Length Protein Name
GI:54607098 DBBJ BAE31710.1 664 unnamed protein product [Mus musculus]
GI:54607098 DBBJ BAE41018.1 664 unnamed protein product [Mus musculus]
GI:54607098 DBBJ BAE27822.1 664 unnamed protein product [Mus musculus]
GI:54607098 DBBJ BAE36754.1 664 unnamed protein product [Mus musculus]
GI:54607098 DBBJ BAE28032.1 664 unnamed protein product [Mus musculus]
GI:54607098 GenBank EDL37092.1 664 succinate dehydrogenase complex, subunit A, flavoprotein (Fp) [Mus musculus]

Related Sequences to LMP000946 proteins

Reference Database Accession Length Protein Name
GI:54607098 DBBJ BAE26754.1 664 unnamed protein product [Mus musculus]
GI:54607098 GenBank AAH11301.1 661 Sdha protein, partial [Mus musculus]
GI:54607098 RefSeq XP_005065480.1 662 PREDICTED: succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [Mesocricetus auratus]
GI:54607098 RefSeq XP_005356789.1 664 PREDICTED: succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [Microtus ochrogaster]
GI:54607098 RefSeq XP_005356790.1 663 PREDICTED: succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X2 [Microtus ochrogaster]
GI:54607098 RefSeq XP_007622007.1 664 PREDICTED: succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [Cricetulus griseus]