Gene/Proteome Database (LMPD)

LMPD ID
LMP000968
Gene ID
51126
Species
Homo sapiens (Human)
Gene Name
N(alpha)-acetyltransferase 20, NatB catalytic subunit
Gene Symbol
NAA20
Synonyms
NAT3; NAT3P; NAT5; NAT5P; dJ1002M8.1
Chromosome
20
Map Location
20p11.23
EC Number
2.3.1.88
Summary
NAT5 is a component of N-acetyltransferase complex B (NatB). Human NatB performs cotranslational N(alpha)-terminal acetylation of methionine residues when they are followed by asparagine (Starheim et al., 2008 [PubMed 18570629]).[supplied by OMIM, Apr 2009]
Orthologs
View orthologs and multiple alignments for NAA20

Proteins

N-alpha-acetyltransferase 20 isoform a
Refseq ID NP_057184
Protein GI 7705823
UniProt ID P61599
mRNA ID NM_016100
Length 178
RefSeq Status VALIDATED
MTTLRAFTCDDLFRFNNINLDPLTETYGIPFYLQYLAHWPEYFIVAEAPGGELMGYIMGKAEGSVAREEWHGHVTALSVAPEFRRLGLAAKLMELLEEISERKGGFFVDLFVRVSNQVAVNMYKQLGYSVYRTVIEYYSASNGEPDEDAYDMRKALSRDTEKKSIIPLPHPVRPEDIE
N-alpha-acetyltransferase 20 isoform b
Refseq ID NP_852668
Protein GI 31563512
UniProt ID A8MZB2
mRNA ID NM_181527
Length 166
RefSeq Status VALIDATED
MLSQSCNLDPLTETYGIPFYLQYLAHWPEYFIVAEAPGGELMGYIMGKAEGSVAREEWHGHVTALSVAPEFRRLGLAAKLMELLEEISERKGGFFVDLFVRVSNQVAVNMYKQLGYSVYRTVIEYYSASNGEPDEDAYDMRKALSRDTEKKSIIPLPHPVRPEDIE
N-alpha-acetyltransferase 20 isoform c
Refseq ID NP_852669
Protein GI 31563514
UniProt ID P61599
mRNA ID NM_181528
Length 111
RefSeq Status VALIDATED
MTTLRAFTCDDLFRFNNINLDPLTETYGIPFYLQYLAHWPEYFIVAEAPGGELMGYIMGKAEGSVAREEWHGHVTALSVAPEFRRLGLAAKLMELLEEISERYEESTFQGY

Gene Information

Entrez Gene ID
51126
Gene Name
N(alpha)-acetyltransferase 20, NatB catalytic subunit
Gene Symbol
NAA20
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0005622 IDA:LIFEdb C intracellular
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0004596 IEA:UniProtKB-EC F peptide alpha-N-acetyltransferase activity

Domain Information

InterPro Annotations

Accession Description
IPR016181 Acyl-CoA N-acyltransferase
IPR000182 GNAT domain

UniProt Annotations

Entry Information

Gene Name
N(alpha)-acetyltransferase 20, NatB catalytic subunit
Protein Entry
NAA20_HUMAN
UniProt ID
P61599
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P61599-1; Sequence=Displayed; Name=2; IsoId=P61599-2; Sequence=VSP_045644; Note=No experimental confirmation available.;
Catalytic Activity Acetyl-CoA + peptide = N(alpha)-acetylpeptide + CoA.
Function Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration.
Sequence Caution Sequence=BG548527; Type=Frameshift; Positions=111; Evidence= ;
Similarity Belongs to the acetyltransferase family. ARD1 subfamily.
Similarity Contains 1 N-acetyltransferase domain.
Subcellular Location Cytoplasm . Nucleus .
Subunit Component of the N-terminal acetyltransferase B (NatB) complex which is composed of NAA20 and NAA25.

Identical and Related Proteins

Unique RefSeq proteins for LMP000968 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
7705823 RefSeq NP_057184 178 N-alpha-acetyltransferase 20 isoform a
31563512 RefSeq NP_852668 166 N-alpha-acetyltransferase 20 isoform b
31563514 RefSeq NP_852669 111 N-alpha-acetyltransferase 20 isoform c

Identical Sequences to LMP000968 proteins

Reference Database Accession Length Protein Name
GI:31563512 GenBank EAX10213.1 166 N-acetyltransferase 5 (ARD1 homolog, S. cerevisiae), isoform CRA_a [Homo sapiens]
GI:31563514 GenBank EAX10214.1 111 N-acetyltransferase 5 (ARD1 homolog, S. cerevisiae), isoform CRA_b [Homo sapiens]
GI:31563514 GenBank ACJ89802.1 111 Sequence 6223 from patent US 7413875
GI:31563514 GenBank JAA12537.1 111 N(alpha)-acetyltransferase 20, NatB catalytic subunit [Pan troglodytes]
GI:31563514 GenBank AHD80504.1 111 Sequence 32850 from patent US 8586006
GI:31563514 RefSeq XP_003316893.1 111 PREDICTED: N-alpha-acetyltransferase 20 isoform X2 [Pan troglodytes]
GI:31563512 RefSeq XP_004061920.1 166 PREDICTED: N-alpha-acetyltransferase 20 isoform 2 [Gorilla gorilla gorilla]
GI:31563514 RefSeq XP_004061921.1 111 PREDICTED: N-alpha-acetyltransferase 20 isoform 3 [Gorilla gorilla gorilla]
GI:31563512 RefSeq XP_005568287.1 166 PREDICTED: N-alpha-acetyltransferase 20 isoform X2 [Macaca fascicularis]
GI:7705823 RefSeq XP_007959542.1 178 PREDICTED: N-alpha-acetyltransferase 20 [Chlorocebus sabaeus]
GI:7705823 RefSeq XP_008050898.1 178 PREDICTED: N-alpha-acetyltransferase 20 isoform X1 [Tarsius syrichta]
GI:7705823 RefSeq XP_008139351.1 178 PREDICTED: N-alpha-acetyltransferase 20 isoform X1 [Eptesicus fuscus]
GI:7705823 RefSeq XP_008586473.1 178 PREDICTED: N-alpha-acetyltransferase 20 isoform X1 [Galeopterus variegatus]
GI:7705823 RefSeq XP_008839549.1 178 PREDICTED: N-alpha-acetyltransferase 20 [Nannospalax galili]
GI:7705823 RefSeq XP_010367421.1 178 PREDICTED: N-alpha-acetyltransferase 20 [Rhinopithecus roxellana]

Related Sequences to LMP000968 proteins

Reference Database Accession Length Protein Name
GI:7705823 GenBank AAH44290.1 178 Nat5-prov protein [Xenopus laevis]
GI:7705823 GenBank AAX29528.1 179 N-acetyltransferase 5, partial [synthetic construct]
GI:7705823 GenBank EDL28493.1 184 N-acetyltransferase 5 (ARD1 homolog, S. cerevisiae), isoform CRA_f [Mus musculus]
GI:7705823 GenBank EDL95139.1 184 N-acetyltransferase 5 (ARD1 homolog, S. cerevisiae) (predicted), isoform CRA_c [Rattus norvegicus]
GI:31563512 GenBank AFE64678.1 178 N-alpha-acetyltransferase 20 isoform a [Macaca mulatta]
GI:31563512 GenBank AFH28674.1 178 N-alpha-acetyltransferase 20, NatB catalytic subunit isoform a [Macaca mulatta]
GI:7705823 RefSeq NP_001080646.1 178 N-alpha-acetyltransferase 20 [Xenopus laevis]
GI:31563514 RefSeq XP_004270465.1 111 PREDICTED: N-alpha-acetyltransferase 20 isoform 2 [Orcinus orca]
GI:31563514 RefSeq XP_004687198.1 111 PREDICTED: N-alpha-acetyltransferase 20 isoform X2 [Condylura cristata]
GI:31563512 RefSeq XP_005381001.1 178 PREDICTED: N-alpha-acetyltransferase 20 isoform X3 [Chinchilla lanigera]
GI:31563514 RefSeq XP_005568288.1 111 PREDICTED: N-alpha-acetyltransferase 20 isoform X3 [Macaca fascicularis]
GI:31563512 RefSeq XP_005672789.1 201 PREDICTED: N-alpha-acetyltransferase 20-like isoform X2 [Sus scrofa]
GI:31563514 RefSeq XP_006097588.1 111 PREDICTED: N-alpha-acetyltransferase 20 isoform X4 [Myotis lucifugus]
GI:31563512 RefSeq XP_006218241.1 185 PREDICTED: N-alpha-acetyltransferase 20 [Vicugna pacos]
GI:31563514 RefSeq XP_007191953.1 111 PREDICTED: N-alpha-acetyltransferase 20 isoform X3 [Balaenoptera acutorostrata scammoni]
GI:31563514 RefSeq XP_007454589.1 111 PREDICTED: N-alpha-acetyltransferase 20 isoform X2 [Lipotes vexillifer]
GI:31563512 RefSeq XP_008538159.1 175 PREDICTED: N-alpha-acetyltransferase 20 isoform X1 [Equus przewalskii]
GI:7705823 SwissProt Q7ZXR3.1 178 RecName: Full=N-alpha-acetyltransferase 20; AltName: Full=Methionine N-acetyltransferase; AltName: Full=N-acetyltransferase 5; AltName: Full=N-terminal acetyltransferase B complex catalytic subunit NAA20; AltName: Full=N-terminal acetyltransferase B complex catalytic subunit NAT5; Short=NatB complex subunit NAT5; AltName: Full=NatB catalytic subunit [Xenopus laevis]