Gene/Proteome Database (LMPD)

LMPD ID
LMP000972
Gene ID
3069
Species
Homo sapiens (Human)
Gene Name
high density lipoprotein binding protein
Gene Symbol
HDLBP
Synonyms
HBP; PRO2900; VGL
Alternate Names
vigilin; HDL-binding protein; high density lipoprotein-binding protein
Chromosome
2
Map Location
2q37.3
Summary
The protein encoded by this gene binds high density lipoprotein (HDL) and may function to regulate excess cholesterol levels in cells. The encoded protein also binds RNA and can induce heterochromatin formation. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Orthologs
View orthologs and multiple alignments for HDLBP

Proteins

vigilin isoform a
Refseq ID NP_976221
Protein GI 42716280
UniProt ID Q00341
mRNA ID NM_203346
Length 1268
RefSeq Status REVIEWED
MSSVAVLTQESFAEHRSGLVPQQIKVATLNSEEESDPPTYKDAFPPLPEKAACLESAQEPAGAWGNKIRPIKASVITQVFHVPLEERKYKDMNQFGEGEQAKICLEIMQRTGAHLELSLAKDQGLSIMVSGKLDAVMKARKDIVARLQTQASATVAIPKEHHRFVIGKNGEKLQDLELKTATKIQIPRPDDPSNQIKITGTKEGIEKARHEVLLISAEQDKRAVERLEVEKAFHPFIAGPYNRLVGEIMQETGTRINIPPPSVNRTEIVFTGEKEQLAQAVARIKKIYEEKKKKTTTIAVEVKKSQHKYVIGPKGNSLQEILERTGVSVEIPPSDSISETVILRGEPEKLGQALTEVYAKANSFTVSSVAAPSWLHRFIIGKKGQNLAKITQQMPKVHIEFTEGEDKITLEGPTEDVNVAQEQIEGMVKDLINRMDYVEINIDHKFHRHLIGKSGANINRIKDQYKVSVRIPPDSEKSNLIRIEGDPQGVQQAKRELLELASRMENERTKDLIIEQRFHRTIIGQKGERIREIRDKFPEVIINFPDPAQKSDIVQLRGPKNEVEKCTKYMQKMVADLVENSYSISVPIFKQFHKNIIGKGGANIKKIREESNTKIDLPAENSNSETIIITGKRANCEAARSRILSIQKDLANIAEVEVSIPAKLHNSLIGTKGRLIRSIMEECGGVHIHFPVEGSGSDTVVIRGPSSDVEKAKKQLLHLAEEKQTKSFTVDIRAKPEYHKFLIGKGGGKIRKVRDSTGARVIFPAAEDKDQDLITIIGKEDAVREAQKELEALIQNLDNVVEDSMLVDPKHHRHFVIRRGQVLREIAEEYGGVMVSFPRSGTQSDKVTLKGAKDCVEAAKKRIQEIIEDLEAQVTLECAIPQKFHRSVMGPKGSRIQQITRDFSVQIKFPDREENAVHSTEPVVQENGDEAGEGREAKDCDPGSPRRCDIIIISGRKEKCEAAKEALEALVPVTIEVEVPFDLHRYVIGQKGSGIRKMMDEFEVNIHVPAPELQSDIIAITGLAANLDRAKAGLLERVKELQAEQEDRALRSFKLSVTVDPKYHPKIIGRKGAVITQIRLEHDVNIQFPDKDDGNQPQDQITITGYEKNTEAARDAILRIVGELEQMVSEDVPLDHRVHARIIGARGKAIRKIMDEFKVDIRFPQSGAPDPNCVTVTGLPENVEEAIDHILNLEEEYLADVVDSEALQVYMKPPAHEEAKAPSRGFVVRDAPWTASSSEKAPDMSSSEEFPSFGAQVAPKTLPWGPKR
vigilin isoform a
Refseq ID NP_005327
Protein GI 4885409
UniProt ID Q00341
mRNA ID NM_005336
Length 1268
RefSeq Status REVIEWED
Protein sequence is identical to GI:42716280 (mRNA isoform)
vigilin isoform b
Refseq ID NP_001230829
Protein GI 345199283
UniProt ID Q00341
mRNA ID NM_001243900
Length 1235
RefSeq Status REVIEWED
MHLAERDRWLFVATVMMHFVSIKSGFPGLCVGVRSTMSSVAVLTQESFAEHRSGLVPQQIKVATLNSEEESDPPTYKDAFPPLPEKAACLESAQEPAGAWGNKIRPIKASVITQVFHVPLEERKYKDMNQFGEGEQAKICLEIMQRTGAHLELSLAKDQGLSIMVSGKLDAVMKARKDIVARLQTQASATVAIPKEHHRFVIGKNGEKLQDLELKTATKIQIPRPDDPSNQIKITGTKEGIEKARHEVLLISAEQDKRAVERLEVEKAFHPFIAGPYNRLVGEIMQETGTRINIPPPSVNRTEIVFTGEKEQLAQAVARIKKIYEEKANSFTVSSVAAPSWLHRFIIGKKGQNLAKITQQMPKVHIEFTEGEDKITLEGPTEDVNVAQEQIEGMVKDLINRMDYVEINIDHKFHRHLIGKSGANINRIKDQYKVSVRIPPDSEKSNLIRIEGDPQGVQQAKRELLELASRMENERTKDLIIEQRFHRTIIGQKGERIREIRDKFPEVIINFPDPAQKSDIVQLRGPKNEVEKCTKYMQKMVADLVENSYSISVPIFKQFHKNIIGKGGANIKKIREESNTKIDLPAENSNSETIIITGKRANCEAARSRILSIQKDLANIAEVEVSIPAKLHNSLIGTKGRLIRSIMEECGGVHIHFPVEGSGSDTVVIRGPSSDVEKAKKQLLHLAEEKQTKSFTVDIRAKPEYHKFLIGKGGGKIRKVRDSTGARVIFPAAEDKDQDLITIIGKEDAVREAQKELEALIQNLDNVVEDSMLVDPKHHRHFVIRRGQVLREIAEEYGGVMVSFPRSGTQSDKVTLKGAKDCVEAAKKRIQEIIEDLEAQVTLECAIPQKFHRSVMGPKGSRIQQITRDFSVQIKFPDREENAVHSTEPVVQENGDEAGEGREAKDCDPGSPRRCDIIIISGRKEKCEAAKEALEALVPVTIEVEVPFDLHRYVIGQKGSGIRKMMDEFEVNIHVPAPELQSDIIAITGLAANLDRAKAGLLERVKELQAEQEDRALRSFKLSVTVDPKYHPKIIGRKGAVITQIRLEHDVNIQFPDKDDGNQPQDQITITGYEKNTEAARDAILRIVGELEQMVSEDVPLDHRVHARIIGARGKAIRKIMDEFKVDIRFPQSGAPDPNCVTVTGLPENVEEAIDHILNLEEEYLADVVDSEALQVYMKPPAHEEAKAPSRGFVVRDAPWTASSSEKAPDMSSSEEFPSFGAQVAPKTLPWGPKR

Gene Information

Entrez Gene ID
3069
Gene Name
high density lipoprotein binding protein
Gene Symbol
HDLBP
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:HPA C cytoplasm
GO:0034364 IEA:UniProtKB-KW C high-density lipoprotein particle
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0005886 TAS:ProtInc C plasma membrane
GO:0008289 TAS:ProtInc F lipid binding
GO:0044822 IDA:UniProtKB F poly(A) RNA binding
GO:0008203 TAS:ProtInc P cholesterol metabolic process
GO:0006869 IEA:UniProtKB-KW P lipid transport

Domain Information

InterPro Annotations

Accession Description
IPR004087 K Homology domain
IPR004088 K Homology domain, type 1

UniProt Annotations

Entry Information

Gene Name
high density lipoprotein binding protein
Protein Entry
VIGLN_HUMAN
UniProt ID
Q00341
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q00341-1; Sequence=Displayed; Name=2; IsoId=Q00341-2; Sequence=VSP_044924, VSP_044925; Note=No experimental confirmation available.;
Function Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol.
Interaction P49711:CTCF; NbExp=4; IntAct=EBI-1049478, EBI-932887;
Similarity Contains 14 KH domains. {ECO
Subcellular Location Cytoplasm . Nucleus .

Identical and Related Proteins

Unique RefSeq proteins for LMP000972 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
42716280 RefSeq NP_976221 1268 vigilin isoform a
345199283 RefSeq NP_001230829 1235 vigilin isoform b

Identical Sequences to LMP000972 proteins

Reference Database Accession Length Protein Name
GI:345199283 DBBJ BAG62064.1 1235 unnamed protein product [Homo sapiens]
GI:42716280 GenBank ADS30976.1 1268 Sequence 1508 from patent US 7781168
GI:42716280 RefSeq XP_005247057.2 1268 PREDICTED: vigilin isoform X2 [Homo sapiens]
GI:42716280 RefSeq XP_005247060.2 1268 PREDICTED: vigilin isoform X5 [Homo sapiens]
GI:42716280 RefSeq XP_006712538.1 1268 PREDICTED: vigilin isoform X6 [Homo sapiens]
GI:42716280 RefSeq XP_005247058.2 1268 PREDICTED: vigilin isoform X3 [Homo sapiens]
GI:42716280 RefSeq XP_005247059.2 1268 PREDICTED: vigilin isoform X4 [Homo sapiens]

Related Sequences to LMP000972 proteins

Reference Database Accession Length Protein Name
GI:42716280 DBBJ BAG35256.1 1268 unnamed protein product [Homo sapiens]
GI:42716280 GenBank AAY14717.1 1268 unknown [Homo sapiens]
GI:42716280 GenBank AED82243.1 1268 Sequence 980 from patent US 7919467
GI:42716280 RefSeq XP_001160571.1 1268 PREDICTED: vigilin [Pan troglodytes]
GI:42716280 RefSeq XP_004033510.1 1268 PREDICTED: vigilin [Gorilla gorilla gorilla]
GI:345199283 RefSeq XP_004262574.1 1220 PREDICTED: vigilin isoform 2 [Orcinus orca]
GI:345199283 RefSeq XP_004427809.1 1199 PREDICTED: vigilin isoform 2 [Ceratotherium simum simum]
GI:345199283 RefSeq XP_004667873.1 1199 PREDICTED: vigilin isoform X2 [Jaculus jaculus]
GI:345199283 RefSeq XP_005077256.1 1199 PREDICTED: vigilin isoform X3 [Mesocricetus auratus]
GI:345199283 RefSeq XP_005610825.1 1199 PREDICTED: vigilin isoform X2 [Equus caballus]
GI:345199283 RefSeq XP_005636036.1 1219 PREDICTED: vigilin isoform X4 [Canis lupus familiaris]
GI:42716280 SwissProt Q00341.2 1268 RecName: Full=Vigilin; AltName: Full=High density lipoprotein-binding protein; Short=HDL-binding protein [Homo sapiens]