Gene/Proteome Database (LMPD)

LMPD ID
LMP000977
Gene ID
11770
Species
Mus musculus (Mouse)
Gene Name
fatty acid binding protein 4, adipocyte
Gene Symbol
Fabp4
Synonyms
422/aP2; ALBP/Ap2; Ap2; Lbpl
Alternate Names
fatty acid-binding protein, adipocyte; P15; ALBP; AFABP; A-FABP; protein 422; P2 adipocyte protein; adipocyte protein aP2; myelin P2 protein homolog; 3T3-L1 lipid-binding protein; fatty acid-binding protein 4; adipocyte lipid-binding protein; adipocyte-type fatty acid-binding protein
Chromosome
3
Map Location
3 A1|3 2.56 cM

Proteins

fatty acid-binding protein, adipocyte
Refseq ID NP_077717
Protein GI 14149635
UniProt ID P04117
mRNA ID NM_024406
Length 132
RefSeq Status VALIDATED
MCDAFVGTWKLVSSENFDDYMKEVGVGFATRKVAGMAKPNMIISVNGDLVTIRSESTFKNTEISFKLGVEFDEITADDRKVKSIITLDGGALVQVQKWDGKSTTIKRKRDGDKLVVECVMKGVTSTRVYERA

Gene Information

Entrez Gene ID
11770
Gene Name
fatty acid binding protein 4, adipocyte
Gene Symbol
Fabp4
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0005654 TAS:Reactome C nucleoplasm
GO:0008289 IEA:UniProtKB-KW F lipid binding
GO:0005215 IEA:InterPro F transporter activity
GO:0050873 IDA:MGI P brown fat cell differentiation
GO:0071285 IDA:MGI P cellular response to lithium ion
GO:0042632 IMP:MGI P cholesterol homeostasis
GO:0001816 IMP:MGI P cytokine production
GO:0006469 IMP:MGI P negative regulation of protein kinase activity
GO:0045892 IMP:MGI P negative regulation of transcription, DNA-templated
GO:0050729 IMP:MGI P positive regulation of inflammatory response
GO:0050872 IDA:MGI P white fat cell differentiation

KEGG Pathway Links

KEGG Pathway ID Description
mmu03320 PPAR signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID Description
442533 Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes

Domain Information

InterPro Annotations

Accession Description
IPR012674 Calycin
IPR011038 Calycin-like
IPR000463 Cytosolic fatty-acid binding
IPR000566 Lipocalin/cytosolic fatty-acid binding domain

UniProt Annotations

Entry Information

Gene Name
fatty acid binding protein 4, adipocyte
Protein Entry
FABP4_MOUSE
UniProt ID
P04117
Species
Mouse

Comments

Comment Type Description
Domain Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.
Function Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus. {ECO:0000269|PubMed:12077340, ECO:0000269|PubMed:16574478, ECO:0000269|PubMed:17516629}.
Similarity Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. {ECO:0000305}.
Subcellular Location Cytoplasm. Nucleus. Note=Depending on the nature of the ligand, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus. Subject to constitutive nuclear export.
Subunit Monomer (By similarity). Homodimer. Interacts with PPARG. {ECO:0000250, ECO:0000269|PubMed:12077340, ECO:0000269|PubMed:14594993, ECO:0000269|PubMed:16574478, ECO:0000269|PubMed:17761196, ECO:0000269|PubMed:7929228, ECO:0000269|PubMed:8161548}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000977 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
14149635 RefSeq NP_077717 132 fatty acid-binding protein, adipocyte

Identical Sequences to LMP000977 proteins

Reference Database Accession Length Protein Name
GI:14149635 DBBJ BAB22601.1 132 unnamed protein product [Mus musculus]
GI:14149635 DBBJ BAC40410.1 132 unnamed protein product [Mus musculus]
GI:14149635 EMBL CAJ18597.1 132 Fabp4 [Mus musculus]
GI:14149635 GenBank AAA39416.1 132 lipid-binding protein [Mus musculus]
GI:14149635 GenBank AAH54426.1 132 Fatty acid binding protein 4, adipocyte [Mus musculus]
GI:14149635 GenBank EDL05171.1 132 fatty acid binding protein 4, adipocyte [Mus musculus]

Related Sequences to LMP000977 proteins

Reference Database Accession Length Protein Name
GI:14149635 PDB 2ANS 131 Chain A, Adipocyte Lipid Binding Protein Complexed With 1-anilino-8-naphthalene Sulfonate
GI:14149635 PDB 2ANS 131 Chain B, Adipocyte Lipid Binding Protein Complexed With 1-anilino-8-naphthalene Sulfonate
GI:14149635 PDB 1ADL 131 Chain A, Adipocyte Lipid Binding Protein Complexed With Arachidonic Acid: X-Ray Crystallographic And Titration Calorimetry Studies
GI:14149635 PDB 2QM9 155 Chain A, Troglitazone Bound To Fatty Acid Binding Protein 4
GI:14149635 PDB 2QM9 155 Chain B, Troglitazone Bound To Fatty Acid Binding Protein 4
GI:14149635 PDB 2Q9S 155 Chain A, Linoleic Acid Bound To Fatty Acid Binding Protein 4