Gene/Proteome Database (LMPD)
LMPD ID
LMP000983
Gene ID
Species
Homo sapiens (Human)
Gene Name
stearoyl-CoA desaturase (delta-9-desaturase)
Gene Symbol
Synonyms
FADS5; MSTP008; SCD1; SCDOS
Alternate Names
acyl-CoA desaturase; delta-9 desaturase; delta-9-desaturase; delta(9)-desaturase; fatty acid desaturase; predicted protein of HQ0998; stearoyl-CoA desaturase opposite strand
Chromosome
10
Map Location
10q24.31
EC Number
1.14.19.1
Summary
This gene encodes an enzyme involved in fatty acid biosynthesis, primarily the synthesis of oleic acid. Transcripts of approximately 3.9 and 5.2 kb, differing only by alternative polyadenlyation signals, have been detected. A gene encoding a similar enzyme is located on chromosome 4 and a pseudogene of this gene is located on chromosome 17. [provided by RefSeq, Feb 2012]
Orthologs
Proteins
| acyl-CoA desaturase | |
|---|---|
| Refseq ID | NP_005054 |
| Protein GI | 53759151 |
| UniProt ID | O00767 |
| mRNA ID | NM_005063 |
| Length | 359 |
| RefSeq Status | VALIDATED |
| MPAHLLQDDISSSYTTTTTITAPPSRVLQNGGDKLETMPLYLEDDIRPDIKDDIYDPTYKDKEGPSPKVEYVWRNIILMSLLHLGALYGITLIPTCKFYTWLWGVFYYFVSALGITAGAHRLWSHRSYKARLPLRLFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGSTLDLSDLEAEKLVMFQRRYYKPGLLMMCFILPTLVPWYFWGETFQNSVFVATFLRYAVVLNATWLVNSAAHLFGYRPYDKNISPRENILVSLGAVGEGFHNYHHSFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAILARIKRTGDGNYKSG | |
Gene Information
Entrez Gene ID
Gene Name
stearoyl-CoA desaturase (delta-9-desaturase)
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005783 | IDA:HPA | C | endoplasmic reticulum |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0016020 | IDA:UniProtKB | C | membrane |
| GO:0005506 | IEA:InterPro | F | iron ion binding |
| GO:0004768 | TAS:ProtInc | F | stearoyl-CoA 9-desaturase activity |
| GO:0006633 | IEA:UniProtKB-KW | P | fatty acid biosynthetic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| hsa04152 | AMPK signaling pathway |
Domain Information
UniProt Annotations
Entry Information
Gene Name
stearoyl-CoA desaturase (delta-9-desaturase)
Protein Entry
ACOD_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | Stearoyl-CoA + 2 ferrocytochrome b5 + O(2) + 2 H(+) = oleoyl-CoA + 2 ferricytochrome b5 + 2 H(2)O. |
| Cofactor | Name=Fe cation; Xref=ChEBI |
| Domain | The histidine box domains may contain the active site and/or be involved in metal ion binding. |
| Function | Terminal component of the liver microsomal stearyl-CoA desaturase system, that utilizes O(2) and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA. |
| Similarity | Belongs to the fatty acid desaturase family. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO |
Identical and Related Proteins
Unique RefSeq proteins for LMP000983 (as displayed in Record Overview)
Identical Sequences to LMP000983 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:53759151 | DBBJ | BAG35237.1 | 359 | unnamed protein product [Homo sapiens] |
| GI:53759151 | GenBank | AHE01952.1 | 359 | Sequence 59402 from patent US 8586006 |
| GI:53759151 | SwissProt | O00767.2 | 359 | RecName: Full=Acyl-CoA desaturase; AltName: Full=Delta(9)-desaturase; Short=Delta-9 desaturase; AltName: Full=Fatty acid desaturase; AltName: Full=Stearoyl-CoA desaturase [Homo sapiens] |
Related Sequences to LMP000983 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:53759151 | DBBJ | BAA93510.1 | 359 | stearoyl-CoA desaturase [Homo sapiens] |
| GI:53759151 | DBBJ | BAI47202.1 | 359 | stearoyl-CoA desaturase, partial [synthetic construct] |
| GI:53759151 | GenBank | AAD29870.1 | 359 | stearoyl-CoA desaturase [Homo sapiens] |
| GI:53759151 | GenBank | ABU29331.1 | 359 | Sequence 5 from patent US 7232662 |
| GI:53759151 | GenBank | ACH36752.1 | 359 | Sequence 13 from patent US 7411054 |
| GI:53759151 | GenBank | ACK08923.1 | 359 | Sequence 5 from patent US 7435559 |