Gene/Proteome Database (LMPD)
LMPD ID
LMP000988
Gene ID
Species
Mus musculus (Mouse)
Gene Name
alcohol dehydrogenase 5 (class III), chi polypeptide
Gene Symbol
Synonyms
Adh-5; Adh3; GSNOR
Alternate Names
alcohol dehydrogenase class-3; FDH; FALDH; ADH-B2; GSH-FDH; alcohol dehydrogenase 2; alcohol dehydrogenase B2; S-nitrosoglutathione reductase; alcohol dehydrogenase class-III; S-(hydroxymethyl)glutathione dehydrogenase; glutathione-dependent formaldehyde dehydrogenase
Chromosome
3
Map Location
3 G3|3
EC Number
1.1.1.1
Proteins
alcohol dehydrogenase class-3 isoform 1 | |
---|---|
Refseq ID | NP_031436 |
Protein GI | 31982511 |
UniProt ID | P28474 |
mRNA ID | NM_007410 |
Length | 374 |
RefSeq Status | VALIDATED |
MANQVIRCKAAVAWEAGKPLSIEEIEVAPPKAHEVRIKILATAVCHTDAYTLSGADPEGCFPVILGHEGAGIVESVGEGVTKLKAGDTVIPLYIPQCGECKFCLNPKTNLCQKIRVTQGKGLMPDGTSRFTCKGKSVFHFMGTSTFSEYTVVADISVAKIDPSAPLDKVCLLGCGISTGYGAAVNTAKVEPGSTCAVFGLGGVGLAVIMGCKVAGASRIIGIDINKDKFAKAKEFGASECISPQDFSKSIQEVLVEMTDGGVDYSFECIGNVKVMRSALEAAHKGWGVSVVVGVAASGEEISTRPFQLVTGRTWKGTAFGGWKSVESVPKLVSEYMSKKIKVDEFVTGNLSFDQINQAFDLMHSGDSIRTVLKM |
alcohol dehydrogenase class-3 isoform 2 | |
---|---|
Refseq ID | NP_001275507 |
Protein GI | 568384738 |
UniProt ID | P28474 |
mRNA ID | NM_001288578 |
Length | 252 |
RefSeq Status | VALIDATED |
MPDGTSRFTCKGKSVFHFMGTSTFSEYTVVADISVAKIDPSAPLDKVCLLGCGISTGYGAAVNTAKVEPGSTCAVFGLGGVGLAVIMGCKVAGASRIIGIDINKDKFAKAKEFGASECISPQDFSKSIQEVLVEMTDGGVDYSFECIGNVKVMRSALEAAHKGWGVSVVVGVAASGEEISTRPFQLVTGRTWKGTAFGGWKSVESVPKLVSEYMSKKIKVDEFVTGNLSFDQINQAFDLMHSGDSIRTVLKM |
Gene Information
Entrez Gene ID
Gene Name
alcohol dehydrogenase 5 (class III), chi polypeptide
Gene Symbol
Species
Mus musculus
Gene Ontology (GO Annotations)
GO ID | Source | Type | Description |
---|---|---|---|
GO:0070062 | IEA:Ensembl | C | extracellular vesicular exosome |
GO:0005739 | IDA:MGI | C | mitochondrion |
GO:0005634 | IEA:Ensembl | C | nucleus |
GO:0051903 | IMP:MGI | F | S-(hydroxymethyl)glutathione dehydrogenase activity |
GO:0004022 | IDA:MGI | F | alcohol dehydrogenase (NAD) activity |
GO:0005504 | IEA:Ensembl | F | fatty acid binding |
GO:0018467 | IEA:Ensembl | F | formaldehyde dehydrogenase activity |
GO:0042803 | IPI:MGI | F | protein homodimerization activity |
GO:0008270 | IEA:InterPro | F | zinc ion binding |
GO:0007568 | IEA:Ensembl | P | aging |
GO:0006068 | IEA:Ensembl | P | ethanol catabolic process |
GO:0006069 | IEA:InterPro | P | ethanol oxidation |
GO:0046294 | IMP:MGI | P | formaldehyde catabolic process |
GO:0018119 | IMP:MGI | P | peptidyl-cysteine S-nitrosylation |
GO:0045777 | IMP:MGI | P | positive regulation of blood pressure |
GO:0003016 | IMP:MGI | P | respiratory system process |
GO:0032496 | IMP:MGI | P | response to lipopolysaccharide |
GO:0051409 | IMP:MGI | P | response to nitrosative stress |
GO:0051775 | IEA:Ensembl | P | response to redox state |
GO:0001523 | IMP:MGI | P | retinoid metabolic process |
KEGG Pathway Links
Domain Information
InterPro Annotations
Accession | Description |
---|---|
IPR013154 | Alcohol dehydrogenase GroES-like |
IPR014183 | Alcohol dehydrogenase class III/S-(hydroxymethyl)glutathione dehydrogenase |
IPR002085 | Alcohol dehydrogenase superfamily, zinc-type |
IPR013149 | Alcohol dehydrogenase, C-terminal |
IPR002328 | Alcohol dehydrogenase, zinc-type, conserved site |
IPR011032 | GroES (chaperonin 10)-like |
IPR016040 | NAD(P)-binding domain |
UniProt Annotations
Entry Information
Gene Name
alcohol dehydrogenase 5 (class III), chi polypeptide
Protein Entry
ADHX_MOUSE
UniProt ID
Species
Mouse
Comments
Comment Type | Description |
---|---|
Catalytic Activity | An alcohol + NAD(+) = an aldehyde or ketone + NADH. |
Catalytic Activity | S-(hydroxymethyl)glutathione + NAD(P)(+) = S- formylglutathione + NAD(P)H. |
Cofactor | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Note=Binds 2 Zn(2+) ions per subunit. {ECO:0000250}; |
Function | Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. |
Similarity | Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. {ECO:0000305}. |
Subcellular Location | Cytoplasm. |
Subunit | Homodimer. |
Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:7738026}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP000988 (as displayed in Record Overview)
Protein GI | Database | Accession | Length | Protein Name |
---|---|---|---|---|
31982511 | RefSeq | NP_031436 | 374 | alcohol dehydrogenase class-3 isoform 1 |
568384738 | RefSeq | NP_001275507 | 252 | alcohol dehydrogenase class-3 isoform 2 |
Identical Sequences to LMP000988 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:31982511 | DBBJ | BAC36370.1 | 374 | unnamed protein product [Mus musculus] |
GI:31982511 | DBBJ | BAE27558.1 | 374 | unnamed protein product [Mus musculus] |
GI:31982511 | GenBank | AAH90978.1 | 374 | Alcohol dehydrogenase 5 (class III), chi polypeptide [Mus musculus] |
GI:31982511 | GenBank | AAH62879.2 | 374 | Alcohol dehydrogenase 5 (class III), chi polypeptide [Mus musculus] |
GI:31982511 | GenBank | EDL12095.1 | 374 | alcohol dehydrogenase 5 (class III), chi polypeptide [Mus musculus] |
GI:31982511 | SwissProt | P28474.3 | 374 | RecName: Full=Alcohol dehydrogenase class-3; AltName: Full=Alcohol dehydrogenase 2; AltName: Full=Alcohol dehydrogenase 5; AltName: Full=Alcohol dehydrogenase B2; Short=ADH-B2; AltName: Full=Alcohol dehydrogenase class-III; AltName: Full=Glutathione-dependent formaldehyde dehydrogenase; Short=FALDH; Short=FDH; Short=GSH-FDH; AltName: Full=S-(hydroxymethyl)glutathione dehydrogenase [Mus musculus] |
Related Sequences to LMP000988 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:568384738 | DBBJ | BAC36370.1 | 374 | unnamed protein product [Mus musculus] |
GI:568384738 | DBBJ | BAE27558.1 | 374 | unnamed protein product [Mus musculus] |
GI:31982511 | DBBJ | BAE35383.1 | 374 | unnamed protein product [Mus musculus] |
GI:31982511 | GenBank | AAA68896.1 | 374 | alcohol dehydrogenase-B2 [Mus musculus domesticus] |
GI:31982511 | GenBank | AAC52763.1 | 374 | class III alcohol dehydrogenase [Mus musculus] |
GI:31982511 | GenBank | AAH83724.1 | 379 | Adh5 protein, partial [Rattus norvegicus] |
GI:568384738 | GenBank | AAH90978.1 | 374 | Alcohol dehydrogenase 5 (class III), chi polypeptide [Mus musculus] |
GI:568384738 | GenBank | AAH62879.2 | 374 | Alcohol dehydrogenase 5 (class III), chi polypeptide [Mus musculus] |
GI:31982511 | PRF | - | 374 | formaldehyde dehydrogenase [Mus musculus] |
GI:568384738 | RefSeq | NP_031436.2 | 374 | alcohol dehydrogenase class-3 isoform 1 [Mus musculus] |
GI:31982511 | RefSeq | NP_001119592.1 | 374 | alcohol dehydrogenase class-3 [Rattus norvegicus] |
GI:568384738 | SwissProt | P28474.3 | 374 | RecName: Full=Alcohol dehydrogenase class-3; AltName: Full=Alcohol dehydrogenase 2; AltName: Full=Alcohol dehydrogenase 5; AltName: Full=Alcohol dehydrogenase B2; Short=ADH-B2; AltName: Full=Alcohol dehydrogenase class-III; AltName: Full=Glutathione-dependent formaldehyde dehydrogenase; Short=FALDH; Short=FDH; Short=GSH-FDH; AltName: Full=S-(hydroxymethyl)glutathione dehydrogenase [Mus musculus] |