Gene/Proteome Database (LMPD)

LMPD ID
LMP000988
Gene ID
11532
Species
Mus musculus (Mouse)
Gene Name
alcohol dehydrogenase 5 (class III), chi polypeptide
Gene Symbol
Adh5
Synonyms
Adh-5; Adh3; GSNOR
Alternate Names
alcohol dehydrogenase class-3; FDH; FALDH; ADH-B2; GSH-FDH; alcohol dehydrogenase 2; alcohol dehydrogenase B2; S-nitrosoglutathione reductase; alcohol dehydrogenase class-III; S-(hydroxymethyl)glutathione dehydrogenase; glutathione-dependent formaldehyde dehydrogenase
Chromosome
3
Map Location
3 G3|3
EC Number
1.1.1.1

Proteins

alcohol dehydrogenase class-3 isoform 1
Refseq ID NP_031436
Protein GI 31982511
UniProt ID P28474
mRNA ID NM_007410
Length 374
RefSeq Status VALIDATED
MANQVIRCKAAVAWEAGKPLSIEEIEVAPPKAHEVRIKILATAVCHTDAYTLSGADPEGCFPVILGHEGAGIVESVGEGVTKLKAGDTVIPLYIPQCGECKFCLNPKTNLCQKIRVTQGKGLMPDGTSRFTCKGKSVFHFMGTSTFSEYTVVADISVAKIDPSAPLDKVCLLGCGISTGYGAAVNTAKVEPGSTCAVFGLGGVGLAVIMGCKVAGASRIIGIDINKDKFAKAKEFGASECISPQDFSKSIQEVLVEMTDGGVDYSFECIGNVKVMRSALEAAHKGWGVSVVVGVAASGEEISTRPFQLVTGRTWKGTAFGGWKSVESVPKLVSEYMSKKIKVDEFVTGNLSFDQINQAFDLMHSGDSIRTVLKM
alcohol dehydrogenase class-3 isoform 2
Refseq ID NP_001275507
Protein GI 568384738
UniProt ID P28474
mRNA ID NM_001288578
Length 252
RefSeq Status VALIDATED
MPDGTSRFTCKGKSVFHFMGTSTFSEYTVVADISVAKIDPSAPLDKVCLLGCGISTGYGAAVNTAKVEPGSTCAVFGLGGVGLAVIMGCKVAGASRIIGIDINKDKFAKAKEFGASECISPQDFSKSIQEVLVEMTDGGVDYSFECIGNVKVMRSALEAAHKGWGVSVVVGVAASGEEISTRPFQLVTGRTWKGTAFGGWKSVESVPKLVSEYMSKKIKVDEFVTGNLSFDQINQAFDLMHSGDSIRTVLKM

Gene Information

Entrez Gene ID
11532
Gene Name
alcohol dehydrogenase 5 (class III), chi polypeptide
Gene Symbol
Adh5
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005739 IDA:MGI C mitochondrion
GO:0005634 IEA:Ensembl C nucleus
GO:0051903 IMP:MGI F S-(hydroxymethyl)glutathione dehydrogenase activity
GO:0004022 IDA:MGI F alcohol dehydrogenase (NAD) activity
GO:0005504 IEA:Ensembl F fatty acid binding
GO:0018467 IEA:Ensembl F formaldehyde dehydrogenase activity
GO:0042803 IPI:MGI F protein homodimerization activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0007568 IEA:Ensembl P aging
GO:0006068 IEA:Ensembl P ethanol catabolic process
GO:0006069 IEA:InterPro P ethanol oxidation
GO:0046294 IMP:MGI P formaldehyde catabolic process
GO:0018119 IMP:MGI P peptidyl-cysteine S-nitrosylation
GO:0045777 IMP:MGI P positive regulation of blood pressure
GO:0003016 IMP:MGI P respiratory system process
GO:0032496 IMP:MGI P response to lipopolysaccharide
GO:0051409 IMP:MGI P response to nitrosative stress
GO:0051775 IEA:Ensembl P response to redox state
GO:0001523 IMP:MGI P retinoid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu01200 Carbon metabolism
mmu05204 Chemical carcinogenesis
mmu01220 Degradation of aromatic compounds
mmu00010 Glycolysis / Gluconeogenesis

Domain Information

InterPro Annotations

Accession Description
IPR013154 Alcohol dehydrogenase GroES-like
IPR014183 Alcohol dehydrogenase class III/S-(hydroxymethyl)glutathione dehydrogenase
IPR002085 Alcohol dehydrogenase superfamily, zinc-type
IPR013149 Alcohol dehydrogenase, C-terminal
IPR002328 Alcohol dehydrogenase, zinc-type, conserved site
IPR011032 GroES (chaperonin 10)-like
IPR016040 NAD(P)-binding domain

UniProt Annotations

Entry Information

Gene Name
alcohol dehydrogenase 5 (class III), chi polypeptide
Protein Entry
ADHX_MOUSE
UniProt ID
P28474
Species
Mouse

Comments

Comment Type Description
Catalytic Activity An alcohol + NAD(+) = an aldehyde or ketone + NADH.
Catalytic Activity S-(hydroxymethyl)glutathione + NAD(P)(+) = S- formylglutathione + NAD(P)H.
Cofactor Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Note=Binds 2 Zn(2+) ions per subunit. {ECO:0000250};
Function Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione.
Similarity Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. {ECO:0000305}.
Subcellular Location Cytoplasm.
Subunit Homodimer.
Tissue Specificity Ubiquitous. {ECO:0000269|PubMed:7738026}.

Identical and Related Proteins

Unique RefSeq proteins for LMP000988 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
31982511 RefSeq NP_031436 374 alcohol dehydrogenase class-3 isoform 1
568384738 RefSeq NP_001275507 252 alcohol dehydrogenase class-3 isoform 2

Identical Sequences to LMP000988 proteins

Reference Database Accession Length Protein Name
GI:31982511 DBBJ BAC36370.1 374 unnamed protein product [Mus musculus]
GI:31982511 DBBJ BAE27558.1 374 unnamed protein product [Mus musculus]
GI:31982511 GenBank AAH90978.1 374 Alcohol dehydrogenase 5 (class III), chi polypeptide [Mus musculus]
GI:31982511 GenBank AAH62879.2 374 Alcohol dehydrogenase 5 (class III), chi polypeptide [Mus musculus]
GI:31982511 GenBank EDL12095.1 374 alcohol dehydrogenase 5 (class III), chi polypeptide [Mus musculus]
GI:31982511 SwissProt P28474.3 374 RecName: Full=Alcohol dehydrogenase class-3; AltName: Full=Alcohol dehydrogenase 2; AltName: Full=Alcohol dehydrogenase 5; AltName: Full=Alcohol dehydrogenase B2; Short=ADH-B2; AltName: Full=Alcohol dehydrogenase class-III; AltName: Full=Glutathione-dependent formaldehyde dehydrogenase; Short=FALDH; Short=FDH; Short=GSH-FDH; AltName: Full=S-(hydroxymethyl)glutathione dehydrogenase [Mus musculus]

Related Sequences to LMP000988 proteins

Reference Database Accession Length Protein Name
GI:568384738 DBBJ BAC36370.1 374 unnamed protein product [Mus musculus]
GI:568384738 DBBJ BAE27558.1 374 unnamed protein product [Mus musculus]
GI:31982511 DBBJ BAE35383.1 374 unnamed protein product [Mus musculus]
GI:31982511 GenBank AAA68896.1 374 alcohol dehydrogenase-B2 [Mus musculus domesticus]
GI:31982511 GenBank AAC52763.1 374 class III alcohol dehydrogenase [Mus musculus]
GI:31982511 GenBank AAH83724.1 379 Adh5 protein, partial [Rattus norvegicus]
GI:568384738 GenBank AAH90978.1 374 Alcohol dehydrogenase 5 (class III), chi polypeptide [Mus musculus]
GI:568384738 GenBank AAH62879.2 374 Alcohol dehydrogenase 5 (class III), chi polypeptide [Mus musculus]
GI:31982511 PRF - 374 formaldehyde dehydrogenase [Mus musculus]
GI:568384738 RefSeq NP_031436.2 374 alcohol dehydrogenase class-3 isoform 1 [Mus musculus]
GI:31982511 RefSeq NP_001119592.1 374 alcohol dehydrogenase class-3 [Rattus norvegicus]
GI:568384738 SwissProt P28474.3 374 RecName: Full=Alcohol dehydrogenase class-3; AltName: Full=Alcohol dehydrogenase 2; AltName: Full=Alcohol dehydrogenase 5; AltName: Full=Alcohol dehydrogenase B2; Short=ADH-B2; AltName: Full=Alcohol dehydrogenase class-III; AltName: Full=Glutathione-dependent formaldehyde dehydrogenase; Short=FALDH; Short=FDH; Short=GSH-FDH; AltName: Full=S-(hydroxymethyl)glutathione dehydrogenase [Mus musculus]