Gene/Proteome Database (LMPD)

LMPD ID
LMP000994
Gene ID
6482
Species
Homo sapiens (Human)
Gene Name
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
Gene Symbol
ST3GAL1
Synonyms
Gal-NAc6S; SIAT4A; SIATFL; ST3GalA; ST3GalA.1; ST3GalIA; ST3GalIA,1; ST3O
Alternate Names
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1; SIAT4-A; ST3GalI; alpha 2,3-ST 1; beta-galactoside alpha-2,3-sialyltransferase 1; Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase; sialyltransferase 4A (beta-galactoside alpha-2,3-sialytransferase); sialyltransferase 4A (beta-galactoside alpha-2,3-sialyltransferase); sialyltransferase 4A (beta-galactosidase alpha-2,3-sialytransferase)
Chromosome
8
Map Location
8q24.22
EC Number
2.4.99.4
Summary
The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi but can be proteolytically processed to a soluble form. Correct glycosylation of the encoded protein may be critical to its sialyltransferase activity. This protein, which is a member of glycosyltransferase family 29, can use the same acceptor substrates as does sialyltransferase 4B. Two transcript variants encoding the same protein have been found for this gene. Other transcript variants may exist, but have not been fully characterized yet. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for ST3GAL1

Proteins

CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1
Refseq ID NP_775479
Protein GI 27765096
UniProt ID Q11201
mRNA ID NM_173344
Length 340
RefSeq Status REVIEWED
MVTLRKRTLKVLTFLVLFIFLTSFFLNYSHTMVATTWFPKQMVLELSENLKRLIKHRPCTCTHCIGQRKLSAWFDERFNQTMQPLLTAQNALLEDDTYRWWLRLQREKKPNNLNDTIKELFRVVPGNVDPMLEKRSVGCRRCAVVGNSGNLRESSYGPEIDSHDFVLRMNKAPTAGFEADVGTKTTHHLVYPESFRELGDNVSMILVPFKTIDLEWVVSAITTGTISHTYIPVPAKIRVKQDKILIYHPAFIKYVFDNWLQGHGRYPSTGILSVIFSMHVCDEVDLYGFGADSKGNWHHYWENNPSAGAFRKTGVHDADFESNVTATLASINKIRIFKGR
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1
Refseq ID NP_003024
Protein GI 4506951
UniProt ID Q11201
mRNA ID NM_003033
Length 340
RefSeq Status REVIEWED
Protein sequence is identical to GI:27765096 (mRNA isoform)

Gene Information

Entrez Gene ID
6482
Gene Name
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
Gene Symbol
ST3GAL1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0000139 TAS:Reactome C Golgi membrane
GO:0070062 IDA:UniProt C extracellular vesicular exosome
GO:0030173 IEA:InterPro C integral component of Golgi membrane
GO:0016020 IDA:UniProtKB C membrane
GO:0003836 ISS:UniProtKB F beta-galactoside (CMP) alpha-2,3-sialyltransferase activity
GO:0006054 ISS:UniProtKB P N-acetylneuraminate metabolic process
GO:0016266 TAS:Reactome P O-glycan processing
GO:0005975 TAS:Reactome P carbohydrate metabolic process
GO:0044267 TAS:Reactome P cellular protein metabolic process
GO:0006464 TAS:ProtInc P cellular protein modification process
GO:0030203 TAS:Reactome P glycosaminoglycan metabolic process
GO:0018146 TAS:Reactome P keratan sulfate biosynthetic process
GO:0042339 TAS:Reactome P keratan sulfate metabolic process
GO:0043687 TAS:Reactome P post-translational protein modification
GO:0006487 ISS:UniProtKB P protein N-linked glycosylation
GO:0006468 IEA:Ensembl P protein phosphorylation
GO:0097503 ISS:UniProtKB P sialylation
GO:0044281 TAS:Reactome P small molecule metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa00533 Glycosaminoglycan biosynthesis - keratan sulfate
hsa00512 Mucin type O-Glycan biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_121120 Keratan sulfate biosynthesis
REACT_200874 Sialic acid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR001675 Glycosyl transferase, family 29
IPR012163 Sialyltransferase

UniProt Annotations

Entry Information

Gene Name
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
Protein Entry
SIA4A_HUMAN
UniProt ID
Q11201
Species
Human

Comments

Comment Type Description
Catalytic Activity CMP-N-acetylneuraminate + beta-D-galactosyl- 1,3-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N- acetylneuraminyl-2,3-beta-D-galactosyl-1,3-N-acetyl-alpha-D- galactosaminyl-R.
Function It may be responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found on sugar chains O- linked to Thr or Ser and also as a terminal sequence on certain gangliosides. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values.
Pathway Protein modification; protein glycosylation.
Ptm The soluble form derives from the membrane form by proteolytic processing.
Similarity Belongs to the glycosyltransferase 29 family.
Subcellular Location Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane- bound form in trans cisternae of Golgi. Secreted into the body fluid.
Tissue Specificity Expressed in several tissues. Highest expression in lung, liver, skeletal muscle, kidney, pancreas, spleen and placenta.
Web Resource Name=Functional Glycomics Gateway - GTase; Note=ST3Gal I; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_622";
Web Resource Name=GGDB; Note=GlycoGene database; URL="http://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ST3GAL1";

Identical and Related Proteins

Unique RefSeq proteins for LMP000994 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
27765096 RefSeq NP_775479 340 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1

Identical Sequences to LMP000994 proteins

Reference Database Accession Length Protein Name
GI:27765096 GenBank AGV82202.1 340 Sequence 524 from patent US 8524238
GI:27765096 GenBank AGV82203.1 340 Sequence 525 from patent US 8524238
GI:27765096 GenBank AGV82204.1 340 Sequence 526 from patent US 8524238
GI:27765096 GenBank AGV82205.1 340 Sequence 527 from patent US 8524238
GI:27765096 GenBank AIC55122.1 340 ST3GAL1, partial [synthetic construct]
GI:27765096 RefSeq XP_006716680.1 340 PREDICTED: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X4 [Homo sapiens]

Related Sequences to LMP000994 proteins

Reference Database Accession Length Protein Name
GI:27765096 GenBank AAA36612.1 340 sialyltransferase [Homo sapiens]
GI:27765096 GenBank AAE01602.1 340 Sequence 16 from patent US 5858751
GI:27765096 GenBank JAA08490.1 340 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 [Pan troglodytes]
GI:27765096 RefSeq XP_008953698.1 340 PREDICTED: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 [Pan paniscus]
GI:27765096 RefSeq XP_008953699.1 340 PREDICTED: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 [Pan paniscus]
GI:27765096 RefSeq XP_009454198.1 340 PREDICTED: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1 [Pan troglodytes]