Gene/Proteome Database (LMPD)

LMPD ID
LMP001003
Gene ID
330450
Species
Mus musculus (Mouse)
Gene Name
fatty acyl CoA reductase 2
Gene Symbol
Far2
Synonyms
A230046P18; AW048109; BC055759; Mlstd1
Alternate Names
fatty acyl-CoA reductase 2; male sterility domain-containing protein 1
Chromosome
6
Map Location
6 G3|6
EC Number
1.2.1.n2

Proteins

fatty acyl-CoA reductase 2
Refseq ID NP_848912
Protein GI 30520289
UniProt ID Q7TNT2
mRNA ID NM_178797
Length 502
RefSeq Status PROVISIONAL
MSMIAAFYSNKSILITGATGFLGKVLMEKLFRTSPHLKVIYILVRPKSGQTLQERVFQILNSKLFEKVKEVCPNVHEKIRPISADLNQRDFAISKEDVQELLSCTNIIFHCAATVRFDAHLREAVQLNVTATQQLLLMASQMPKLEAFIHISTAFSNCNLSHIDEVIYPCPVEPRKIIDSMEWLDDSIIEEITPKLIGDRPNTYTYTKALGEIVVQQESGNLNVAIVRPSIVGATWQEPFPGWVDNLNGPSGLIIATGKGFLRSIKATPMAVADVIPVDTVVNLTIAVGWYTAVHRPKSTLIYHSTSGNLNPCNWYKMGLQVLATIEKIPFESAFRRPNADFTTSNFTTHYWNTVSHRVPAIIYDFYLRLTGRKPRMLKLMNRLLKTISMLEYFINHSWEWSTNNTEMLLSELSPEDQRVFNFDVRQLNWLEYIENYVLGVKKYLLKEDLAGIPKAKQHLRRLRNIHYLFNTALFLIIWRLLIARSQMARNVWFFICPLFKL

Gene Information

Entrez Gene ID
330450
Gene Name
fatty acyl CoA reductase 2
Gene Symbol
Far2
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005777 IDA:MGI C peroxisome
GO:0080019 IEA:InterPro F fatty-acyl-CoA reductase (alcohol-forming) activity
GO:0050062 IDA:MGI F long-chain-fatty-acyl-CoA reductase activity
GO:0006629 IEA:UniProtKB-KW P lipid metabolic process
GO:0035336 IEA:Ensembl P long-chain fatty-acyl-CoA metabolic process
GO:0010025 TAS:MGI P wax biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ko04146 Peroxisome
mmu04146 Peroxisome

REACTOME Pathway Links

REACTOME Pathway ID Description
5892980 Peroxisomal lipid metabolism
5892979 Plasmalogen biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR026055 Fatty acyl-CoA reductase
IPR013120 Male sterility, NAD-binding
IPR016040 NAD(P)-binding domain

UniProt Annotations

Entry Information

Gene Name
fatty acyl CoA reductase 2
Protein Entry
FACR2_MOUSE
UniProt ID
Q7TNT2
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7TNT2-1; Sequence=Displayed; Name=2; IsoId=Q7TNT2-2; Sequence=VSP_021682; Note=No experimental confirmation available.;
Catalytic Activity Hexadecanal + CoA + NADP(+) = hexadecanoyl-CoA + NADPH.
Function Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. The preferred substrates are C16, C18, C18:1 and C18:2 but low activity can be observed with C10-C14 substrates. {ECO:0000269|PubMed:15220348}.
Similarity Belongs to the fatty acyl-CoA reductase family. {ECO:0000305}.
Subcellular Location Peroxisome membrane {ECO:0000305}; Multi- pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Peroxisome in cells expressing low levels of the protein. Peroxisome and endoplasmic reticulum in cells expressing high levels of the protein (Potential). {ECO:0000305}.
Tissue Specificity Highly expressed in the meibomian glands of the eyelid and the sebaceous glands of the skin. Expressed in the brain where large quantities of ether lipids are synthesized. {ECO:0000269|PubMed:15220348}.

Identical and Related Proteins

Unique RefSeq proteins for LMP001003 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
30520289 RefSeq NP_848912 502 fatty acyl-CoA reductase 2

Identical Sequences to LMP001003 proteins

Reference Database Accession Length Protein Name
GI:30520289 DBBJ BAC31532.1 502 unnamed protein product [Mus musculus]
GI:30520289 DBBJ BAC31590.1 502 unnamed protein product [Mus musculus]

Related Sequences to LMP001003 proteins

Reference Database Accession Length Protein Name
GI:30520289 DBBJ BAC30056.1 502 unnamed protein product [Mus musculus]
GI:30520289 GenBank AAH55759.1 515 Far2 protein [Mus musculus]
GI:30520289 GenBank EDL10740.1 515 male sterility domain containing 1 [Mus musculus]
GI:30520289 RefSeq XP_006507132.1 515 PREDICTED: fatty acyl-CoA reductase 2 isoform X1 [Mus musculus]
GI:30520289 RefSeq XP_006507133.1 515 PREDICTED: fatty acyl-CoA reductase 2 isoform X2 [Mus musculus]
GI:30520289 RefSeq XP_006536153.1 515 PREDICTED: fatty acyl-CoA reductase 2 isoform X1 [Mus musculus]