Gene/Proteome Database (LMPD)

LMPD ID
LMP001012
Gene ID
5833
Species
Homo sapiens (Human)
Gene Name
phosphate cytidylyltransferase 2, ethanolamine
Gene Symbol
PCYT2
Synonyms
ET
Chromosome
17
Map Location
17q25.3
EC Number
2.7.7.14
Summary
This gene encodes an enzyme that catalyzes the formation of CDP-ethanolamine from CTP and phosphoethanolamine in the Kennedy pathway of phospholipid synthesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Orthologs
View orthologs and multiple alignments for PCYT2

Proteins

ethanolamine-phosphate cytidylyltransferase isoform 1
Refseq ID NP_001171846
Protein GI 296841136
UniProt ID Q99447
mRNA ID NM_001184917
Length 407
RefSeq Status REVIEWED
MIRNGRGAAGGAEQPGPGGRRAVRVWCDGCYDMVHYGHSNQLRQARAMGDYLIVGVHTDEEIAKHKGPPVFTQEERYKMVQAIKWVDEVVPAAPYVTTLETLDKYNCDFCVHGNDITLTVDGRDTYEEVKQAGRYRECKRTQGVSTTDLVGRMLLVTKAHHSSQEMSSEYREYADSFGKPPHPIPAGDILSSEGCSQCPGGRNPWTGVSQFLQTSQKIIQFASGKEPQPGETVIYVAGAFDLFHIGHVDFLEKVHRLAERPYIIAGLHFDQEVNHYKGKNYPIMNLHERTLSVLACRYVSEVVIGAPYAVTAELLSHFKVDLVCHGKTEIIPDRDGSDPYQEPKRRGIFRQIDSGSNLTTDLIVQRIITNRLEYEARNQKKEAKELAFLEAARQQAAQPLGERDGDF
ethanolamine-phosphate cytidylyltransferase isoform 2
Refseq ID NP_002852
Protein GI 4505651
UniProt ID Q99447
mRNA ID NM_002861
Length 389
RefSeq Status REVIEWED
MIRNGRGAAGGAEQPGPGGRRAVRVWCDGCYDMVHYGHSNQLRQARAMGDYLIVGVHTDEEIAKHKGPPVFTQEERYKMVQAIKWVDEVVPAAPYVTTLETLDKYNCDFCVHGNDITLTVDGRDTYEEVKQAGRYRECKRTQGVSTTDLVGRMLLVTKAHHSSQEMSSEYREYADSFGKCPGGRNPWTGVSQFLQTSQKIIQFASGKEPQPGETVIYVAGAFDLFHIGHVDFLEKVHRLAERPYIIAGLHFDQEVNHYKGKNYPIMNLHERTLSVLACRYVSEVVIGAPYAVTAELLSHFKVDLVCHGKTEIIPDRDGSDPYQEPKRRGIFRQIDSGSNLTTDLIVQRIITNRLEYEARNQKKEAKELAFLEAARQQAAQPLGERDGDF
ethanolamine-phosphate cytidylyltransferase isoform 4
Refseq ID NP_001243364
Protein GI 374253762
UniProt ID Q99447
mRNA ID NM_001256435
Length 311
RefSeq Status REVIEWED
MVQAIKWVDEVVPAAPYVTTLETLDKYNCDFCVHGNDITLTVDGRDTYEEVKQAGRYRECKRTQGVSTTDLVGRMLLVTKAHHSSQEMSSEYREYADSFGKCPGGRNPWTGVSQFLQTSQKIIQFASGKEPQPGETVIYVAGAFDLFHIGHVDFLEKVHRLAERPYIIAGLHFDQEVNHYKGKNYPIMNLHERTLSVLACRYVSEVVIGAPYAVTAELLSHFKVDLVCHGKTEIIPDRDGSDPYQEPKRRGIFRQIDSGSNLTTDLIVQRIITNRLEYEARNQKKEAKELAFLEAARQQAAQPLGERDGDF
ethanolamine-phosphate cytidylyltransferase isoform 4
Refseq ID NP_001269132
Protein GI 532524975
UniProt ID Q99447
mRNA ID NM_001282203
Length 311
RefSeq Status REVIEWED
Protein sequence is identical to GI:374253762 (mRNA isoform)
ethanolamine-phosphate cytidylyltransferase isoform 6
Refseq ID NP_001269133
Protein GI 532524977
UniProt ID Q99447
mRNA ID NM_001282204
Length 357
RefSeq Status REVIEWED
MVHYGHSNQLRQARAMGDYLIVGVHTDEEIAKHKGPPVFTQEERYKMVQAIKWVDEVVPAAPYVTTLETLDKYNCDFCVHGNDITLTVDGRDTYEEVKQAGRYRECKRTQGVSTTDLVGRMLLVTKAHHSSQEMSSEYREYADSFGKCPGGRNPWTGVSQFLQTSQKIIQFASGKEPQPGETVIYVAGAFDLFHIGHVDFLEKVHRLAERPYIIAGLHFDQEVNHYKGKNYPIMNLHERTLSVLACRYVSEVVIGAPYAVTAELLSHFKVDLVCHGKTEIIPDRDGSDPYQEPKRRGIFRQIDSGSNLTTDLIVQRIITNRLEYEARNQKKEAKELAFLEAARQQAAQPLGERDGDF

Gene Information

Entrez Gene ID
5833
Gene Name
phosphate cytidylyltransferase 2, ethanolamine
Gene Symbol
PCYT2
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 TAS:Reactome C endoplasmic reticulum membrane
GO:0004306 TAS:UniProtKB F ethanolamine-phosphate cytidylyltransferase activity
GO:0046474 TAS:Reactome P glycerophospholipid biosynthetic process
GO:0006646 TAS:Reactome P phosphatidylethanolamine biosynthetic process
GO:0008654 TAS:UniProtKB P phospholipid biosynthetic process
GO:0006644 TAS:Reactome P phospholipid metabolic process
GO:0044281 TAS:Reactome P small molecule metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa00564 Glycerophospholipid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_121401 Glycerophospholipid biosynthesis
REACT_120919 Synthesis of PE

Domain Information

InterPro Annotations

Accession Description
IPR004821 Cytidyltransferase-like domain
IPR014729 Rossmann-like alpha/beta/alpha sandwich fold

UniProt Annotations

Entry Information

Gene Name
phosphate cytidylyltransferase 2, ethanolamine
Protein Entry
PCY2_HUMAN
UniProt ID
Q99447
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q99447-1; Sequence=Displayed; Name=2; IsoId=Q99447-2; Sequence=VSP_045131; Name=3; IsoId=Q99447-3; Sequence=VSP_046844; Note=No experimental confirmation available. Gene prediction based on cDNA data.; Name=4; IsoId=Q99447-4; Sequence=VSP_054615; Note=No experimental confirmation available.;
Catalytic Activity CTP + ethanolamine phosphate = diphosphate + CDP-ethanolamine.
Function Plays an important role in the biosynthesis of the phospholipid phosphatidylethanolamine. Catalyzes the formation of CDP-ethanolamine.
Pathway Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3.
Similarity Belongs to the cytidylyltransferase family.
Tissue Specificity Strongest expression in liver, heart, and skeletal muscle.

Identical and Related Proteins

Unique RefSeq proteins for LMP001012 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
296841136 RefSeq NP_001171846 407 ethanolamine-phosphate cytidylyltransferase isoform 1
4505651 RefSeq NP_002852 389 ethanolamine-phosphate cytidylyltransferase isoform 2
374253762 RefSeq NP_001243364 311 ethanolamine-phosphate cytidylyltransferase isoform 4
532524977 RefSeq NP_001269133 357 ethanolamine-phosphate cytidylyltransferase isoform 6

Identical Sequences to LMP001012 proteins

Reference Database Accession Length Protein Name
GI:374253762 DBBJ BAH13541.1 311 unnamed protein product [Homo sapiens]
GI:532524977 DBBJ BAH14756.1 357 unnamed protein product [Homo sapiens]
GI:296841136 GenBank JAA02769.1 407 phosphate cytidylyltransferase 2, ethanolamine [Pan troglodytes]
GI:4505651 GenBank JAA30262.1 389 phosphate cytidylyltransferase 2, ethanolamine [Pan troglodytes]
GI:296841136 GenBank JAA30263.1 407 phosphate cytidylyltransferase 2, ethanolamine [Pan troglodytes]
GI:4505651 GenBank JAA36356.1 389 phosphate cytidylyltransferase 2, ethanolamine [Pan troglodytes]
GI:4505651 GenBank AGX57897.1 389 Sequence 16095 from patent US 8541208
GI:4505651 GenBank AHD80506.1 389 Sequence 32852 from patent US 8586006
GI:4505651 GenBank AIC49546.1 389 PCYT2, partial [synthetic construct]
GI:4505651 RefSeq NP_001267059.1 389 ethanolamine-phosphate cytidylyltransferase [Pan troglodytes]
GI:374253762 RefSeq NP_001269132.1 311 ethanolamine-phosphate cytidylyltransferase isoform 4 [Homo sapiens]

Related Sequences to LMP001012 proteins

Reference Database Accession Length Protein Name
GI:532524977 EMBL CBF65933.1 389 unnamed protein product [Homo sapiens]
GI:374253762 EMBL CBF65933.1 389 unnamed protein product [Homo sapiens]
GI:296841136 GenBank AAH00351.1 389 Phosphate cytidylyltransferase 2, ethanolamine [Homo sapiens]
GI:532524977 GenBank AAH00351.1 389 Phosphate cytidylyltransferase 2, ethanolamine [Homo sapiens]
GI:374253762 GenBank AAH00351.1 389 Phosphate cytidylyltransferase 2, ethanolamine [Homo sapiens]
GI:4505651 GenBank AAH10075.1 389 Phosphate cytidylyltransferase 2, ethanolamine [Homo sapiens]
GI:4505651 GenBank ACM83130.1 411 Sequence 8628 from patent US 6812339
GI:4505651 GenBank AFH33411.1 389 ethanolamine-phosphate cytidylyltransferase isoform 2 [Macaca mulatta]
GI:4505651 GenBank AFI37871.1 389 ethanolamine-phosphate cytidylyltransferase isoform 2 [Macaca mulatta]
GI:532524977 GenBank JAA02768.1 389 phosphate cytidylyltransferase 2, ethanolamine [Pan troglodytes]
GI:296841136 GenBank JAA02768.1 389 phosphate cytidylyltransferase 2, ethanolamine [Pan troglodytes]
GI:374253762 GenBank JAA02768.1 389 phosphate cytidylyltransferase 2, ethanolamine [Pan troglodytes]
GI:532524977 GenBank JAA18943.1 389 phosphate cytidylyltransferase 2, ethanolamine [Pan troglodytes]
GI:374253762 GenBank JAA18943.1 389 phosphate cytidylyltransferase 2, ethanolamine [Pan troglodytes]
GI:532524977 GenBank JAA30262.1 389 phosphate cytidylyltransferase 2, ethanolamine [Pan troglodytes]
GI:374253762 GenBank JAA30262.1 389 phosphate cytidylyltransferase 2, ethanolamine [Pan troglodytes]
GI:374253762 GenBank JAA36356.1 389 phosphate cytidylyltransferase 2, ethanolamine [Pan troglodytes]
GI:532524977 GenBank JAA36356.1 389 phosphate cytidylyltransferase 2, ethanolamine [Pan troglodytes]
GI:4505651 RefSeq XP_003913624.1 389 PREDICTED: ethanolamine-phosphate cytidylyltransferase isoform X1 [Papio anubis]
GI:296841136 RefSeq XP_005332731.1 404 PREDICTED: ethanolamine-phosphate cytidylyltransferase isoform X1 [Ictidomys tridecemlineatus]
GI:296841136 RefSeq XP_005585330.1 407 PREDICTED: ethanolamine-phosphate cytidylyltransferase isoform X1 [Macaca fascicularis]
GI:4505651 RefSeq XP_005585332.1 389 PREDICTED: ethanolamine-phosphate cytidylyltransferase isoform X3 [Macaca fascicularis]
GI:296841136 RefSeq XP_002806926.3 426 PREDICTED: ethanolamine-phosphate cytidylyltransferase isoform X1 [Callithrix jacchus]
GI:296841136 RefSeq XP_009431794.1 408 PREDICTED: ethanolamine-phosphate cytidylyltransferase isoform X1 [Pan troglodytes]