Gene/Proteome Database (LMPD)
LMPD ID
LMP001044
Gene ID
Species
Homo sapiens (Human)
Gene Name
phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
Gene Symbol
Synonyms
PI5P4KA; PIP5K2A; PIP5KII-alpha; PIP5KIIA; PIPK
Alternate Names
phosphatidylinositol 5-phosphate 4-kinase type-2 alpha; PIP5KIII; PIP5KIIalpha; PIP4KII-alpha; PI(5)P 4-kinase type II alpha; PtdIns(4)P-5-kinase B isoform; ptdIns(4)P-5-kinase C isoform; diphosphoinositide kinase 2-alpha; ptdIns(5)P-4-kinase isoform 2-alpha; 1-phosphatidylinositol-4-phosphate kinase; 1-phosphatidylinositol-4-phosphate-5-kinase; 1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha; 1-phosphatidylinositol-5-phosphate 4-kinase 2-alpha; phosphatidylinositol-5-phosphate 4-kinase type-2 alpha; phosphatidylinositol 5-phosphate 4-kinase type II alpha; phosphatidylinositol-4-phosphate 5-kinase, type II, alpha; type II phosphatidylinositol-4-phosphate 5-kinase 53 K isoform
Chromosome
10
Map Location
10p12.2
EC Number
2.7.1.149
Summary
Phosphatidylinositol-5,4-bisphosphate, the precursor to second messengers of the phosphoinositide signal transduction pathways, is thought to be involved in the regulation of secretion, cell proliferation, differentiation, and motility. The protein encoded by this gene is one of a family of enzymes capable of catalyzing the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. The amino acid sequence of this enzyme does not show homology to other kinases, but the recombinant protein does exhibit kinase activity. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. [provided by RefSeq, Jul 2008]
Orthologs
Proteins
| phosphatidylinositol 5-phosphate 4-kinase type-2 alpha | |
|---|---|
| Refseq ID | NP_005019 |
| Protein GI | 6857820 |
| UniProt ID | P48426 |
| mRNA ID | NM_005028 |
| Length | 406 |
| RefSeq Status | REVIEWED |
| MATPGNLGSSVLASKTKTKKKHFVAQKVKLFRASDPLLSVLMWGVNHSINELSHVQIPVMLMPDDFKAYSKIKVDNHLFNKENMPSHFKFKEYCPMVFRNLRERFGIDDQDFQNSLTRSAPLPNDSQARSGARFHTSYDKRYIIKTITSEDVAEMHNILKKYHQYIVECHGITLLPQFLGMYRLNVDGVEIYVIVTRNVFSHRLSVYRKYDLKGSTVAREASDKEKAKELPTLKDNDFINEGQKIYIDDNNKKVFLEKLKKDVEFLAQLKLMDYSLLVGIHDVERAEQEEVECEENDGEEEGESDGTHPVGTPPDSPGNTLNSSPPLAPGEFDPNIDVYGIKCHENSPRKEVYFMAIIDILTHYDAKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFLDFIGHILT | |
Gene Information
Entrez Gene ID
Gene Name
phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005829 | TAS:Reactome | C | cytosol |
| GO:0005634 | IEA:UniProtKB-KW | C | nucleus |
| GO:0005886 | IEA:UniProtKB-KW | C | plasma membrane |
| GO:0016308 | NAS:UniProtKB | F | 1-phosphatidylinositol-4-phosphate 5-kinase activity |
| GO:0016309 | IEA:UniProtKB-EC | F | 1-phosphatidylinositol-5-phosphate 4-kinase activity |
| GO:0005524 | IEA:UniProtKB-KW | F | ATP binding |
| GO:0035855 | IEA:Ensembl | P | megakaryocyte development |
| GO:0006661 | TAS:Reactome | P | phosphatidylinositol biosynthetic process |
| GO:0046854 | NAS:GOC | P | phosphatidylinositol phosphorylation |
| GO:0006644 | TAS:Reactome | P | phospholipid metabolic process |
| GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
BIOCYC Pathway Links
| BIOCYC Pathway ID | Description |
|---|---|
| PWY-6351 | D-myo-inositol (1,4,5)-trisphosphate biosynthesis |
| PWY-6367 | D-myo-inositol-5-phosphate metabolism |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_121025 | Synthesis of PIPs at the plasma membrane |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR023610 | Phosphatidylinositol-4-phosphate 5-kinase |
| IPR027483 | Phosphatidylinositol-4-phosphate 5-kinase, C-terminal |
| IPR027484 | Phosphatidylinositol-4-phosphate 5-kinase, N-terminal domain |
| IPR002498 | Phosphatidylinositol-4-phosphate 5-kinase, core |
| IPR016034 | Phosphatidylinositol-4-phosphate 5-kinase, core, subgroup |
UniProt Annotations
Entry Information
Gene Name
phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
Protein Entry
PI42A_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P48426-1; Sequence=Displayed; Name=2; IsoId=P48426-2; Sequence=VSP_056458; Note=No experimental confirmation available.; |
| Biophysicochemical Properties | Kinetic parameters: KM=50 uM for phosphatidylinositol-5- phosphate ; Vmax=466 pmol/min/ug enzyme ; |
| Catalytic Activity | ATP + 1-phosphatidyl-1D-myo-inositol 5- phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate. |
| Caution | This protein was previously thought to be a phosphatidylinositol 4-phosphate 5-kinase. |
| Function | Catalyzes the phosphorylation of phosphatidylinositol 5- phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May negatively regulate insulin- stimulated glucose uptake by lowering the levels of PtdIns5P. May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size. |
| Similarity | Contains 1 PIPK domain. {ECO |
| Subcellular Location | Cell membrane . Nucleus . Cytoplasm . Note=May translocate from the cytosol to the cell membrane upon activation of tyrosine phosphorylation. May translocate from the inner to the outer segments of the rod photoreceptor cells in response to light (By similarity). Localization to the nucleus is modulated by the interaction with PIP4K2B. |
| Subunit | Homodimer (By similarity). Interacts with PIP4K2B. Interaction with PIP4K2B may regulate localization to the nucleus. |
| Tissue Specificity | Expressed ubiquitously, with high levels in the brain. Present in most tissues, except notably skeletal muscle and small intestine. {ECO |
Identical and Related Proteins
Unique RefSeq proteins for LMP001044 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 6857820 | RefSeq | NP_005019 | 406 | phosphatidylinositol 5-phosphate 4-kinase type-2 alpha |
Identical Sequences to LMP001044 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6857820 | GenBank | AHD77914.1 | 406 | Sequence 24541 from patent US 8586006 |
| GI:6857820 | GenBank | AIC49400.1 | 406 | PIP4K2A, partial [synthetic construct] |
| GI:6857820 | GenBank | AIC62559.1 | 406 | PIP4K2A, partial [synthetic construct] |
| GI:6857820 | RefSeq | XP_005564849.1 | 406 | PREDICTED: phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1 [Macaca fascicularis] |
| GI:6857820 | RefSeq | XP_008000681.1 | 406 | PREDICTED: phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1 [Chlorocebus sabaeus] |
| GI:6857820 | RefSeq | XP_010365864.1 | 406 | PREDICTED: phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [Rhinopithecus roxellana] |
Related Sequences to LMP001044 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6857820 | GenBank | AAX43277.1 | 407 | phosphatidylinositol-4-phosphate 5-kinase type II alpha, partial [synthetic construct] |
| GI:6857820 | GenBank | JAB04499.1 | 406 | phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [Callithrix jacchus] |
| GI:6857820 | GenBank | JAB15457.1 | 406 | phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [Callithrix jacchus] |
| GI:6857820 | RefSeq | XP_003930713.1 | 406 | PREDICTED: phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [Saimiri boliviensis boliviensis] |
| GI:6857820 | RefSeq | XP_004280994.1 | 406 | PREDICTED: phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform 1 [Orcinus orca] |
| GI:6857820 | RefSeq | XP_007454226.1 | 406 | PREDICTED: phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1 [Lipotes vexillifer] |