Gene/Proteome Database (LMPD)

LMPD ID
LMP001048
Gene ID
2908
Species
Homo sapiens (Human)
Gene Name
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
Gene Symbol
NR3C1
Synonyms
GCCR; GCR; GCRST; GR; GRL
Chromosome
5
Map Location
5q31.3
Summary
This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]
Orthologs
View orthologs and multiple alignments for NR3C1

Proteins

glucocorticoid receptor isoform GR-P
Refseq ID NP_001191194
Protein GI 66528677
UniProt ID P04150
mRNA ID NM_001204265
Length 778
RefSeq Status REVIEWED
MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRRLLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLKLLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGNVKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLIDENCLLSPLAGEDDSFLLEGNSNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEKEDFIELCTPGVIKQEKLGTVYCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVGSENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGRQHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK
glucocorticoid receptor isoform alpha
Refseq ID NP_000167
Protein GI 4504133
UniProt ID P04150
mRNA ID NM_000176
Length 777
RefSeq Status REVIEWED
MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRRLLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLKLLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGNVKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLIDENCLLSPLAGEDDSFLLEGNSNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEKEDFIELCTPGVIKQEKLGTVYCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVGSENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK
glucocorticoid receptor isoform alpha
Refseq ID NP_001018084
Protein GI 66528530
UniProt ID P04150
mRNA ID NM_001018074
Length 777
RefSeq Status REVIEWED
Protein sequence is identical to GI:4504133 (mRNA isoform)
glucocorticoid receptor isoform alpha
Refseq ID NP_001018085
Protein GI 66528563
UniProt ID P04150
mRNA ID NM_001018075
Length 777
RefSeq Status REVIEWED
Protein sequence is identical to GI:4504133 (mRNA isoform)
glucocorticoid receptor isoform alpha
Refseq ID NP_001018086
Protein GI 66528586
UniProt ID P04150
mRNA ID NM_001018076
Length 777
RefSeq Status REVIEWED
Protein sequence is identical to GI:4504133 (mRNA isoform)
glucocorticoid receptor isoform alpha
Refseq ID NP_001018087
Protein GI 66528611
UniProt ID P04150
mRNA ID NM_001018077
Length 777
RefSeq Status REVIEWED
Protein sequence is identical to GI:4504133 (mRNA isoform)
glucocorticoid receptor isoform alpha-B
Refseq ID NP_001191187
Protein GI 66528677
UniProt ID P04150
mRNA ID NM_001204258
Length 778
RefSeq Status REVIEWED
MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRRLLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLKLLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGNVKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLIDENCLLSPLAGEDDSFLLEGNSNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEKEDFIELCTPGVIKQEKLGTVYCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVGSENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGRQHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK
glucocorticoid receptor isoform alpha-C1
Refseq ID NP_001191188
Protein GI 66528677
UniProt ID P04150
mRNA ID NM_001204259
Length 778
RefSeq Status REVIEWED
MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRRLLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLKLLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGNVKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLIDENCLLSPLAGEDDSFLLEGNSNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEKEDFIELCTPGVIKQEKLGTVYCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVGSENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGRQHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK
glucocorticoid receptor isoform alpha-C2
Refseq ID NP_001191189
Protein GI 66528677
UniProt ID P04150
mRNA ID NM_001204260
Length 778
RefSeq Status REVIEWED
MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRRLLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLKLLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGNVKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLIDENCLLSPLAGEDDSFLLEGNSNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEKEDFIELCTPGVIKQEKLGTVYCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVGSENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGRQHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK
glucocorticoid receptor isoform alpha-C3
Refseq ID NP_001191190
Protein GI 66528677
UniProt ID P04150
mRNA ID NM_001204261
Length 778
RefSeq Status REVIEWED
MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRRLLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLKLLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGNVKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLIDENCLLSPLAGEDDSFLLEGNSNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEKEDFIELCTPGVIKQEKLGTVYCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVGSENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGRQHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK
glucocorticoid receptor isoform alpha-D1
Refseq ID NP_001191191
Protein GI 66528677
UniProt ID P04150
mRNA ID NM_001204262
Length 778
RefSeq Status REVIEWED
MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRRLLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLKLLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGNVKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLIDENCLLSPLAGEDDSFLLEGNSNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEKEDFIELCTPGVIKQEKLGTVYCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVGSENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGRQHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK
glucocorticoid receptor isoform alpha-D2
Refseq ID NP_001191192
Protein GI 66528677
UniProt ID P04150
mRNA ID NM_001204263
Length 778
RefSeq Status REVIEWED
MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRRLLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLKLLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGNVKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLIDENCLLSPLAGEDDSFLLEGNSNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEKEDFIELCTPGVIKQEKLGTVYCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVGSENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGRQHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK
glucocorticoid receptor isoform alpha-D3
Refseq ID NP_001191193
Protein GI 66528677
UniProt ID P04150
mRNA ID NM_001204264
Length 778
RefSeq Status REVIEWED
MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRRLLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLKLLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGNVKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLIDENCLLSPLAGEDDSFLLEGNSNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEKEDFIELCTPGVIKQEKLGTVYCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVGSENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGRQHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK
glucocorticoid receptor isoform beta
Refseq ID NP_001018661
Protein GI 66528642
UniProt ID P04150
mRNA ID NM_001020825
Length 742
RefSeq Status REVIEWED
MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRRLLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLKLLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGNVKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLIDENCLLSPLAGEDDSFLLEGNSNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEKEDFIELCTPGVIKQEKLGTVYCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVGSENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHENVMWLKPESTSHTLI
glucocorticoid receptor isoform gamma
Refseq ID NP_001019265
Protein GI 66528677
UniProt ID P04150
mRNA ID NM_001024094
Length 778
RefSeq Status REVIEWED
MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRRLLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLKLLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGNVKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLIDENCLLSPLAGEDDSFLLEGNSNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEKEDFIELCTPGVIKQEKLGTVYCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVGSENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGRQHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK

Gene Information

Entrez Gene ID
2908
Gene Name
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
Gene Symbol
NR3C1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:HPA C cytoplasm
GO:0005829 IEA:Ensembl C cytosol
GO:0016020 IEA:Ensembl C membrane
GO:0005759 TAS:ProtInc C mitochondrial matrix
GO:0005654 TAS:Reactome C nucleoplasm
GO:0005634 IDA:HPA C nucleus
GO:0000978 IDA:NTNU_SB F RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 IDA:NTNU_SB F RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0004883 TAS:ProtInc F glucocorticoid receptor activity
GO:0003700 TAS:ProtInc F sequence-specific DNA binding transcription factor activity
GO:0005496 IEA:UniProtKB-KW F steroid binding
GO:0008270 IEA:InterPro F zinc ion binding
GO:0030325 IEA:Ensembl P adrenal gland development
GO:0016568 IEA:UniProtKB-KW P chromatin modification
GO:0010467 TAS:Reactome P gene expression
GO:0008211 IEA:Ensembl P glucocorticoid metabolic process
GO:0060603 IEA:Ensembl P mammary gland duct morphogenesis
GO:1900170 IEA:Ensembl P negative regulation of glucocorticoid mediated signaling pathway
GO:0043525 IEA:Ensembl P positive regulation of neuron apoptotic process
GO:0045944 IDA:NTNU_SB P positive regulation of transcription from RNA polymerase II promoter
GO:0031946 IEA:Ensembl P regulation of glucocorticoid biosynthetic process
GO:0006111 IEA:Ensembl P regulation of gluconeogenesis
GO:0006355 IDA:UniProtKB P regulation of transcription, DNA-templated
GO:0007165 TAS:ProtInc P signal transduction
GO:0006366 TAS:ProtInc P transcription from RNA polymerase II promoter
GO:0006367 TAS:Reactome P transcription initiation from RNA polymerase II promoter
GO:0006351 TAS:ProtInc P transcription, DNA-templated

Domain Information

InterPro Annotations

Accession Description
IPR001409 Glucocorticoid receptor
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001723 Steroid hormone receptor
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
Protein Entry
E5KQF6_HUMAN
UniProt ID
P04150
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing, Alternative initiation; Named isoforms=10; Comment=At least 4 isoforms, Alpha (shown here), Alpha-B, Beta and Beta-B, are produced by alternative initiation at Met-1 and Met-27. The existence of isoform Alpha and isoform Alpha-B has been proved by mutagenesis. As the sequence environment of the 2 potential ATG initiator codons is the same for the other alternatively spliced isoforms, alternative initiation of translation could also occur on these transcripts. Additional isoforms seem to exist. {ECO
Disease Glucocorticoid resistance (GCRES) [MIM
Domain Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
Function Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic genes expression. {ECO
Interaction P31749:AKT1; NbExp=5; IntAct=EBI-493507, EBI-296087; P59598:Asxl1 (xeno); NbExp=2; IntAct=EBI-493507, EBI-5743705; Q03135:CAV1; NbExp=2; IntAct=EBI-493507, EBI-603614; P01730:CD4; NbExp=2; IntAct=EBI-493507, EBI-353826; P00533:EGFR; NbExp=2; IntAct=EBI-493507, EBI-297353; Q6ZU52:KIAA0408; NbExp=2; IntAct=EBI-493507, EBI-739493; P06239:LCK; NbExp=3; IntAct=EBI-493507, EBI-1348; Q62667:Mvp (xeno); NbExp=2; IntAct=EBI-493507, EBI-918333; P82094:TMF1; NbExp=3; IntAct=EBI-493507, EBI-949763;
Miscellaneous Can up- or down-modulate aggregation and nuclear localization of expanded polyglutamine polypeptides derived from AR and HD through specific regulation of gene expression. Aggregation and nuclear localization of expanded polyglutamine proteins are regulated cellular processes that can be modulated by this receptor, a well-characterized transcriptional regulator.
Miscellaneous High constitutive expression of isoform Beta by neutrophils may provide a mechanism by which these cells escape glucocorticoid-induced cell death. Up-regulation by proinflammatory cytokines such as IL8 further enhances their survival in the presence of glucocorticoids during inflammation.
Polymorphism Carriers of the 22-Glu-Lys-23 allele are relatively more resistant to the effects of GCs with respect to the sensitivity of the adrenal feedback mechanism than non-carriers, resulting in a better metabolic health profile. Carriers have a better survival than non-carriers, as well as lower serum CRP levels. The 22-Glu-Lys-23 polymorphism is associated with a sex- specific, beneficial body composition at young-adult age, as well as greater muscle strength in males.
Ptm Acetylation by CLOCK reduces its binding to glucocorticoid response elements and its transcriptional activity.
Ptm Increased proteasome-mediated degradation in response to glucocorticoids.
Ptm Phosphorylated in the absence of hormone; becomes hyperphosphorylated in the presence of glucocorticoid. The Ser- 203-phosphorylated form is mainly cytoplasmic, and the Ser-211- phosphorylated form is nuclear. Transcriptional activity correlates with the amount of phosphorylation at Ser-211. May be dephosphorylated by PPP5C, attenuates NR3C1 action.
Ptm Sumoylated; this reduces transcription transactivation.
Ptm Ubiquitinated; restricts glucocorticoid-mediated transcriptional signaling.
Similarity Belongs to the nuclear hormone receptor family. NR3 subfamily.
Similarity Contains 1 nuclear receptor DNA-binding domain.
Subcellular Location Cytoplasm. Mitochondrion. Nucleus. Note=Cytoplasmic in the absence of ligand, nuclear after ligand- binding.
Subcellular Location Isoform Beta: Nucleus. Note=Localized largely in the nucleus.
Subunit Heteromultimeric cytoplasmic complex with HSP90AA1, HSPA1A/HSPA1B, and FKBP5 or another immunophilin such as PPID, STIP1, or the immunophilin homolog PPP5C. Upon ligand binding FKBP5 dissociates from the complex and FKBP4 takes its place, thereby linking the complex to dynein and mediating transport to the nucleus, where the complex dissociates. Directly interacts with UNC45A. Binds to DNA as a homodimer, and as heterodimer with NR3C2 or the retinoid X receptor. Binds STAT5A and STAT5B homodimers and heterodimers. Interacts with NRIP1, POU2F1, POU2F2 and TRIM28. Interacts with several coactivator complexes, including the SMARCA4 complex, CREBBP/EP300, TADA2L (Ada complex) and p160 coactivators such as NCOA2 and NCOA6. Interaction with BAG1 inhibits transactivation. Interacts with HEXIM1, PELP1 and TGFB1I1. Interacts with NCOA1, NCOA3, SMARCA4, SMARCC1, SMARCD1, and SMARCE1. Interacts with CLOCK, CRY1 and CRY2 in a ligand- dependent fashion. Interacts with CIART. Interacts with RWDD3. Interacts with UBE2I/UBC9 and this interaction is enhanced in the presence of RWDD3. {ECO
Tissue Specificity Widely expressed. In the heart, detected in left and right atria, left and right ventricles, aorta, apex, intraventricular septum, and atrioventricular node as well as whole adult and fetal heart.
Web Resource Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/nr3c1/";
Web Resource Name=Wikipedia; Note=Glucocorticoid receptor entry; URL="http://en.wikipedia.org/wiki/Glucocorticoid_receptor";

Identical and Related Proteins

Unique RefSeq proteins for LMP001048 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
66528677 RefSeq NP_001191194 778 glucocorticoid receptor isoform GR-P
4504133 RefSeq NP_000167 777 glucocorticoid receptor isoform alpha
66528677 RefSeq NP_001191187 778 glucocorticoid receptor isoform alpha-B
66528677 RefSeq NP_001191188 778 glucocorticoid receptor isoform alpha-C1
66528677 RefSeq NP_001191189 778 glucocorticoid receptor isoform alpha-C2
66528677 RefSeq NP_001191190 778 glucocorticoid receptor isoform alpha-C3
66528677 RefSeq NP_001191191 778 glucocorticoid receptor isoform alpha-D1
66528677 RefSeq NP_001191192 778 glucocorticoid receptor isoform alpha-D2
66528677 RefSeq NP_001191193 778 glucocorticoid receptor isoform alpha-D3
66528642 RefSeq NP_001018661 742 glucocorticoid receptor isoform beta
66528677 RefSeq NP_001019265 778 glucocorticoid receptor isoform gamma

Identical Sequences to LMP001048 proteins

Reference Database Accession Length Protein Name
GI:66528642 GenBank ADP91248.1 742 glucocorticoid receptor [Homo sapiens]
GI:66528642 GenBank ADP91251.1 742 glucocorticoid receptor [Homo sapiens]
GI:66528642 GenBank AEU56607.1 742 Sequence 119 from patent US 8067189
GI:66528642 GenBank AEW40340.1 742 Sequence 210 from patent US 8071291
GI:66528642 GenBank AFC04887.1 742 Sequence 327 from patent US 8110361
GI:4504133 GenBank AHD70531.1 777 Sequence 3206 from patent US 8586006
GI:4504133 GenBank AHD70532.1 777 Sequence 3207 from patent US 8586006
GI:4504133 GenBank AHD70533.1 777 Sequence 3208 from patent US 8586006
GI:4504133 GenBank AHD70534.1 777 Sequence 3209 from patent US 8586006
GI:4504133 GenBank AHD70535.1 777 Sequence 3210 from patent US 8586006
GI:66528642 GenBank AHD70536.1 742 Sequence 3211 from patent US 8586006
GI:66528677 GenBank AHD70537.1 778 Sequence 3212 from patent US 8586006
GI:66528677 GenBank AHD70537.1 778 Sequence 3212 from patent US 8586006
GI:66528677 GenBank AHD70537.1 778 Sequence 3212 from patent US 8586006
GI:66528677 GenBank AHD70537.1 778 Sequence 3212 from patent US 8586006
GI:66528677 GenBank AHD70537.1 778 Sequence 3212 from patent US 8586006
GI:66528677 GenBank AHD70537.1 778 Sequence 3212 from patent US 8586006
GI:66528677 GenBank AHD70537.1 778 Sequence 3212 from patent US 8586006
GI:66528677 GenBank AHD70537.1 778 Sequence 3212 from patent US 8586006
GI:66528677 GenBank AHD70537.1 778 Sequence 3212 from patent US 8586006
GI:4504133 GenBank AIC48886.1 777 NR3C1, partial [synthetic construct]
GI:66528677 RefSeq XP_005268476.1 778 PREDICTED: glucocorticoid receptor isoform X1 [Homo sapiens]
GI:66528677 RefSeq XP_005268476.1 778 PREDICTED: glucocorticoid receptor isoform X1 [Homo sapiens]
GI:66528677 RefSeq XP_005268476.1 778 PREDICTED: glucocorticoid receptor isoform X1 [Homo sapiens]
GI:66528677 RefSeq XP_005268476.1 778 PREDICTED: glucocorticoid receptor isoform X1 [Homo sapiens]
GI:66528677 RefSeq XP_005268476.1 778 PREDICTED: glucocorticoid receptor isoform X1 [Homo sapiens]
GI:66528677 RefSeq XP_005268476.1 778 PREDICTED: glucocorticoid receptor isoform X1 [Homo sapiens]
GI:66528677 RefSeq XP_005268476.1 778 PREDICTED: glucocorticoid receptor isoform X1 [Homo sapiens]
GI:66528677 RefSeq XP_005268476.1 778 PREDICTED: glucocorticoid receptor isoform X1 [Homo sapiens]
GI:66528677 RefSeq XP_005268476.1 778 PREDICTED: glucocorticoid receptor isoform X1 [Homo sapiens]
GI:66528677 RefSeq XP_005268477.1 778 PREDICTED: glucocorticoid receptor isoform X2 [Homo sapiens]
GI:66528677 RefSeq XP_005268477.1 778 PREDICTED: glucocorticoid receptor isoform X2 [Homo sapiens]
GI:66528677 RefSeq XP_005268477.1 778 PREDICTED: glucocorticoid receptor isoform X2 [Homo sapiens]
GI:66528677 RefSeq XP_005268477.1 778 PREDICTED: glucocorticoid receptor isoform X2 [Homo sapiens]
GI:66528677 RefSeq XP_005268477.1 778 PREDICTED: glucocorticoid receptor isoform X2 [Homo sapiens]
GI:66528677 RefSeq XP_005268477.1 778 PREDICTED: glucocorticoid receptor isoform X2 [Homo sapiens]
GI:66528677 RefSeq XP_005268477.1 778 PREDICTED: glucocorticoid receptor isoform X2 [Homo sapiens]
GI:66528677 RefSeq XP_005268477.1 778 PREDICTED: glucocorticoid receptor isoform X2 [Homo sapiens]
GI:66528677 RefSeq XP_005268477.1 778 PREDICTED: glucocorticoid receptor isoform X2 [Homo sapiens]
GI:66528677 RefSeq XP_005268478.1 778 PREDICTED: glucocorticoid receptor isoform X3 [Homo sapiens]
GI:66528677 RefSeq XP_005268478.1 778 PREDICTED: glucocorticoid receptor isoform X3 [Homo sapiens]
GI:66528677 RefSeq XP_005268478.1 778 PREDICTED: glucocorticoid receptor isoform X3 [Homo sapiens]
GI:66528677 RefSeq XP_005268478.1 778 PREDICTED: glucocorticoid receptor isoform X3 [Homo sapiens]
GI:66528677 RefSeq XP_005268478.1 778 PREDICTED: glucocorticoid receptor isoform X3 [Homo sapiens]
GI:66528677 RefSeq XP_005268478.1 778 PREDICTED: glucocorticoid receptor isoform X3 [Homo sapiens]
GI:66528677 RefSeq XP_005268478.1 778 PREDICTED: glucocorticoid receptor isoform X3 [Homo sapiens]
GI:66528677 RefSeq XP_005268478.1 778 PREDICTED: glucocorticoid receptor isoform X3 [Homo sapiens]
GI:66528677 RefSeq XP_005268478.1 778 PREDICTED: glucocorticoid receptor isoform X3 [Homo sapiens]
GI:66528677 RefSeq XP_005268479.1 778 PREDICTED: glucocorticoid receptor isoform X4 [Homo sapiens]
GI:66528677 RefSeq XP_005268479.1 778 PREDICTED: glucocorticoid receptor isoform X4 [Homo sapiens]
GI:66528677 RefSeq XP_005268479.1 778 PREDICTED: glucocorticoid receptor isoform X4 [Homo sapiens]
GI:66528677 RefSeq XP_005268479.1 778 PREDICTED: glucocorticoid receptor isoform X4 [Homo sapiens]
GI:66528677 RefSeq XP_005268479.1 778 PREDICTED: glucocorticoid receptor isoform X4 [Homo sapiens]
GI:66528677 RefSeq XP_005268479.1 778 PREDICTED: glucocorticoid receptor isoform X4 [Homo sapiens]
GI:66528677 RefSeq XP_005268479.1 778 PREDICTED: glucocorticoid receptor isoform X4 [Homo sapiens]
GI:66528677 RefSeq XP_005268479.1 778 PREDICTED: glucocorticoid receptor isoform X4 [Homo sapiens]
GI:66528677 RefSeq XP_005268479.1 778 PREDICTED: glucocorticoid receptor isoform X4 [Homo sapiens]
GI:66528677 RefSeq XP_005268480.1 778 PREDICTED: glucocorticoid receptor isoform X5 [Homo sapiens]
GI:66528677 RefSeq XP_005268480.1 778 PREDICTED: glucocorticoid receptor isoform X5 [Homo sapiens]
GI:66528677 RefSeq XP_005268480.1 778 PREDICTED: glucocorticoid receptor isoform X5 [Homo sapiens]
GI:66528677 RefSeq XP_005268480.1 778 PREDICTED: glucocorticoid receptor isoform X5 [Homo sapiens]
GI:66528677 RefSeq XP_005268480.1 778 PREDICTED: glucocorticoid receptor isoform X5 [Homo sapiens]
GI:66528677 RefSeq XP_005268480.1 778 PREDICTED: glucocorticoid receptor isoform X5 [Homo sapiens]
GI:66528677 RefSeq XP_005268480.1 778 PREDICTED: glucocorticoid receptor isoform X5 [Homo sapiens]
GI:66528677 RefSeq XP_005268480.1 778 PREDICTED: glucocorticoid receptor isoform X5 [Homo sapiens]
GI:66528677 RefSeq XP_005268480.1 778 PREDICTED: glucocorticoid receptor isoform X5 [Homo sapiens]

Related Sequences to LMP001048 proteins

Reference Database Accession Length Protein Name
GI:4504133 DBBJ BAD97314.1 777 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) variant, partial [Homo sapiens]
GI:4504133 EMBL CAE45716.1 777 hypothetical protein [Homo sapiens]
GI:4504133 EMBL CAF06534.1 777 unnamed protein product [Homo sapiens]
GI:66528642 GenBank AAB64353.1 777 glucocorticoid receptor alpha [Homo sapiens]
GI:4504133 GenBank AAT15134.1 777 Sequence 2 from patent US 6699686
GI:4504133 GenBank ADP91139.1 778 glucocorticoid receptor [Homo sapiens]
GI:66528677 pat WO 777 Sequence 2 from Patent WO 8803168
GI:66528677 pat WO 777 Sequence 2 from Patent WO 8803168
GI:66528677 pat WO 777 Sequence 2 from Patent WO 8803168
GI:66528677 pat WO 777 Sequence 2 from Patent WO 8803168
GI:66528677 pat WO 777 Sequence 2 from Patent WO 8803168
GI:66528677 pat WO 777 Sequence 2 from Patent WO 8803168
GI:66528677 pat WO 777 Sequence 2 from Patent WO 8803168
GI:66528642 pat WO 777 Sequence 2 from Patent WO 8803168
GI:66528677 pat WO 777 Sequence 2 from Patent WO 8803168
GI:66528677 pat WO 777 Sequence 2 from Patent WO 8803168
GI:66528677 PRF - 777 glucocorticoid receptor alpha [Homo sapiens]
GI:66528642 PRF - 777 glucocorticoid receptor alpha [Homo sapiens]
GI:66528677 PRF - 777 glucocorticoid receptor alpha [Homo sapiens]
GI:66528677 PRF - 777 glucocorticoid receptor alpha [Homo sapiens]
GI:66528677 PRF - 777 glucocorticoid receptor alpha [Homo sapiens]
GI:66528677 PRF - 777 glucocorticoid receptor alpha [Homo sapiens]
GI:66528677 PRF - 777 glucocorticoid receptor alpha [Homo sapiens]
GI:66528677 PRF - 777 glucocorticoid receptor alpha [Homo sapiens]
GI:66528677 PRF - 777 glucocorticoid receptor alpha [Homo sapiens]
GI:66528677 PRF - 777 glucocorticoid receptor alpha [Homo sapiens]
GI:66528677 RefSeq XP_003266613.1 778 PREDICTED: glucocorticoid receptor isoform 6 [Nomascus leucogenys]
GI:66528677 RefSeq XP_003266613.1 778 PREDICTED: glucocorticoid receptor isoform 6 [Nomascus leucogenys]
GI:66528677 RefSeq XP_003266613.1 778 PREDICTED: glucocorticoid receptor isoform 6 [Nomascus leucogenys]
GI:66528677 RefSeq XP_003266613.1 778 PREDICTED: glucocorticoid receptor isoform 6 [Nomascus leucogenys]
GI:66528677 RefSeq XP_003266613.1 778 PREDICTED: glucocorticoid receptor isoform 6 [Nomascus leucogenys]
GI:66528677 RefSeq XP_003266613.1 778 PREDICTED: glucocorticoid receptor isoform 6 [Nomascus leucogenys]
GI:66528677 RefSeq XP_003266613.1 778 PREDICTED: glucocorticoid receptor isoform 6 [Nomascus leucogenys]
GI:66528677 RefSeq XP_003266613.1 778 PREDICTED: glucocorticoid receptor isoform 6 [Nomascus leucogenys]
GI:66528677 RefSeq XP_003266613.1 778 PREDICTED: glucocorticoid receptor isoform 6 [Nomascus leucogenys]
GI:66528642 RefSeq XP_003266615.1 742 PREDICTED: glucocorticoid receptor isoform 8 [Nomascus leucogenys]
GI:4504133 RefSeq XP_003829144.1 777 PREDICTED: glucocorticoid receptor isoform X2 [Pan paniscus]
GI:66528642 RefSeq XP_005558173.1 742 PREDICTED: glucocorticoid receptor isoform X7 [Macaca fascicularis]
GI:66528677 RefSeq XP_008952747.1 778 PREDICTED: glucocorticoid receptor isoform X1 [Pan paniscus]
GI:66528677 RefSeq XP_008952747.1 778 PREDICTED: glucocorticoid receptor isoform X1 [Pan paniscus]
GI:66528677 RefSeq XP_008952747.1 778 PREDICTED: glucocorticoid receptor isoform X1 [Pan paniscus]
GI:66528677 RefSeq XP_008952747.1 778 PREDICTED: glucocorticoid receptor isoform X1 [Pan paniscus]
GI:66528677 RefSeq XP_008952747.1 778 PREDICTED: glucocorticoid receptor isoform X1 [Pan paniscus]
GI:66528677 RefSeq XP_008952747.1 778 PREDICTED: glucocorticoid receptor isoform X1 [Pan paniscus]
GI:66528677 RefSeq XP_008952747.1 778 PREDICTED: glucocorticoid receptor isoform X1 [Pan paniscus]
GI:66528677 RefSeq XP_008952747.1 778 PREDICTED: glucocorticoid receptor isoform X1 [Pan paniscus]
GI:66528677 RefSeq XP_008952747.1 778 PREDICTED: glucocorticoid receptor isoform X1 [Pan paniscus]
GI:66528677 RefSeq XP_008952748.1 778 PREDICTED: glucocorticoid receptor isoform X1 [Pan paniscus]
GI:66528677 RefSeq XP_008952748.1 778 PREDICTED: glucocorticoid receptor isoform X1 [Pan paniscus]
GI:66528677 RefSeq XP_008952748.1 778 PREDICTED: glucocorticoid receptor isoform X1 [Pan paniscus]
GI:66528677 RefSeq XP_008952748.1 778 PREDICTED: glucocorticoid receptor isoform X1 [Pan paniscus]
GI:66528677 RefSeq XP_008952748.1 778 PREDICTED: glucocorticoid receptor isoform X1 [Pan paniscus]
GI:66528677 RefSeq XP_008952748.1 778 PREDICTED: glucocorticoid receptor isoform X1 [Pan paniscus]
GI:66528677 RefSeq XP_008952748.1 778 PREDICTED: glucocorticoid receptor isoform X1 [Pan paniscus]
GI:66528677 RefSeq XP_008952748.1 778 PREDICTED: glucocorticoid receptor isoform X1 [Pan paniscus]
GI:66528677 RefSeq XP_008952748.1 778 PREDICTED: glucocorticoid receptor isoform X1 [Pan paniscus]
GI:66528677 SwissProt P04150.1 777 RecName: Full=Glucocorticoid receptor; Short=GR; AltName: Full=Nuclear receptor subfamily 3 group C member 1 [Homo sapiens]
GI:66528677 SwissProt P04150.1 777 RecName: Full=Glucocorticoid receptor; Short=GR; AltName: Full=Nuclear receptor subfamily 3 group C member 1 [Homo sapiens]
GI:66528677 SwissProt P04150.1 777 RecName: Full=Glucocorticoid receptor; Short=GR; AltName: Full=Nuclear receptor subfamily 3 group C member 1 [Homo sapiens]
GI:66528677 SwissProt P04150.1 777 RecName: Full=Glucocorticoid receptor; Short=GR; AltName: Full=Nuclear receptor subfamily 3 group C member 1 [Homo sapiens]
GI:66528677 SwissProt P04150.1 777 RecName: Full=Glucocorticoid receptor; Short=GR; AltName: Full=Nuclear receptor subfamily 3 group C member 1 [Homo sapiens]
GI:66528642 SwissProt P04150.1 777 RecName: Full=Glucocorticoid receptor; Short=GR; AltName: Full=Nuclear receptor subfamily 3 group C member 1 [Homo sapiens]
GI:66528677 SwissProt P04150.1 777 RecName: Full=Glucocorticoid receptor; Short=GR; AltName: Full=Nuclear receptor subfamily 3 group C member 1 [Homo sapiens]
GI:66528677 SwissProt P04150.1 777 RecName: Full=Glucocorticoid receptor; Short=GR; AltName: Full=Nuclear receptor subfamily 3 group C member 1 [Homo sapiens]
GI:66528677 SwissProt P04150.1 777 RecName: Full=Glucocorticoid receptor; Short=GR; AltName: Full=Nuclear receptor subfamily 3 group C member 1 [Homo sapiens]
GI:66528677 SwissProt P04150.1 777 RecName: Full=Glucocorticoid receptor; Short=GR; AltName: Full=Nuclear receptor subfamily 3 group C member 1 [Homo sapiens]